Sentences with phrase «cell ablation»

Whole - body Induced Cell Turnover (WICT) consists of the qualitative and quantitative coordination of targeted cell ablation with exogenous cell administration so as to effect the replacement of a patient's entire set of endogenous cells with exogenous cells (of the same quantity and cell type as the ablated endogenous cells they are replacing) derived from human pluripotent stem cells and directionally differentiated in vitro prior to their administration.

The described system will use the following algorithms: (1) single pulse guided treatment: the pulse fluence will be automatically maintained to provide the PNB lifetime (size) above the cell ablation threshold.

It should be noted, however, that while a study on senescent cell ablation in genetically normal mice would provide at least some evidence on the effect of senescent cells (and their ablation) on promoting cancer, even such a study would likely show less effect than could be anticipated in a large mammal model, since even normally - aging mice rarely suffer metastatic disease to the extent of aging humans, as sheer primary tumor volume is generally sufficient to be fatal to mice.

Striatal cholinergic cell ablation attenuates L - DOPA induced dyskinesia in Parkinsonian mice.

Myeloid CD11c + Antigen - Presenting Cells Ablation Prevents Hypertension in Response to Angiotensin II Plus High - Salt Diet The Heart Attack Grill is a hospital themed restaurant in downtown Las Vegas.

Not exact matches

Finally, they used a technique called genetic ablation to kill the amacrine cells and horizontal cells altogether and found this resulted in a lack of normal vessel growth in the intermediate layer.

Itch responses were blocked by toxin - mediated ablation of Nppb - receptor — expressing cells, but a second neuropeptide, gastrin - releasing peptide, still induced strong responses in the toxin - treated animals.

During the ablation process, a catheter is snaked through the patient's body to the site of abnormal heart cells.

«A few hours after ablation only few red cells were remaining in the ventricle.

Catheter ablation is the procedure to destroy the misfiring heart cells and improve the heart's electrical communication system.

During catheter ablation, which typically takes four to five hours, cardiologists thread a catheter, or long thin tube, up through a blood vessel from the groin to the heart and use it as a conduit to send radiofrequency energy to cauterize the misfiring cells.

Stein LR, Imai S. Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging.

In mice with kidney and cardiac fibrosis, the ablation of these cells resulted in reduction in fibrosis and rescued heart function.

A well - defined cell type that has been widely used to identify the consequences of ablation or ectopic expression of a gene of interest.

Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E.

Our laboratory has assembled a comprehensive set of tools for doing this, including mice with conditional ablation of the Btla gene in different subsets of immune cells.

Sidoli M, Musner N, Silvestri N, Ungaro D, D'Antonio M, Cavener DR, Feltri ML, Wrabetz L. Ablation of perk in schwann cells improves myelination in the S63del Charcot - Marie - Tooth 1B mouse.

Abrogation of local cancer recurrence after radiofrequency ablation by dendritic cell - based hyperthermic tumor vaccine.

At 9 - 10 mo of age, such mice were then compared a to age - matched cohorts of untreated BubR1H / H; INK - ATTAC mice, and to BubR1H / H mice lacking the INK - ATTAC system for selective ablation of p16Ink4a - expressing cells.

(1) One clear disadvantage of using these «early - aging» mice is that they die too early to develop cancer — too early for ablation of p16Ink4a - positive senescent cells to impact the course of the disease.

On the other hand, there are many other tissues — notably, the kidney and articular cartilage — where p16Ink4a - expressing senescent cells appear to be a contributing factor to human and murine degenerative aging, but which were not evaluated in treated or control mice in this study, and it would be of interest to see the effects of ablation of p16Ink4a - positive senescent cells.

Focal laser ablation is the latest in a series of efforts to target just the cancer cells and preserve normal areas of prostate.

Focal laser ablation uses precisely targeted heat, delivered through a small insertion and guided into the prostate by magnetic resonance imaging, to burn away cancerous cells in the prostate.

To impute aging phenotypes directly to p16Ink4a - expressing senescent cells, van Deursen and colleagues with expertise in the aging and senescence of the relevant tissues developed and tested the effects of a pharmacologically - inducible system for the ablation of p16Ink4a - expressing cells.

(6) Following this initial test of abrogating the early, age - related rise in p16Ink4a - expressing cell burden, the investigators probed the effects of leaving BubR1H / H; INK - ATTAC to undergo 5 months of rapid «premature aging» (and thus, to the attendant accumulation of high levels of p16Ink4a - positive cells and onset of «early - aging» phenotypes), and only then inducing ablation of senescent cells with the INK - ATTAC drug - activated system (see Figure 2 (g) below).

It would indeed be of great interest to see whether ablation of stromal p16Ink4a - expressing senescent cells, in otherwise genetically intact INK - ATTAC animals without existing tumors, would lower the animals» risk for cancer, and put any tumors they might develop on a less malevolent trajectory, than untreated mice.

Multiple cell types acquire distinctive «senescent» phenotypes on a cell - type - specific basis, and will require ablation to achieve comprehensive rejuvenation.

It is unfortunate that the investigators did not assess insulin secretion, insulin action, or systemic inflammation in early - aging BubR1H / H; INK - ATTAC mice, with and without ablation of senescent adipose cells, but reasonable to be optimistic that doing so would yield some normalization of age - related metabolic abnormalities.

Thus, these animals exhibit premature cardiac arrhythmias and stiffening of the arterial wall, and cardiac failure appears to be the main cause of death; yet these tissues are not burdened with an abnormally - high burden of p16Ink4a - senescent cells, and accordingly, ablation p16Ink4a - positive senescent cells in these animals had little tissue - specific or survivorship phenotypic impact.

Recent physical approaches, including the ablation of bonds between cells using laser light, have revealed that mechanical tension on cell bonds is elevated along this anterior - posterior compartment boundary.

Moreover, ablation of a STAT5A allele reduces tumor incidence in a mouse model of breast cancer in which mammary epithelial cells express T antigen (48).

New approaches to microscopy, precision laser ablation of individual cells and capillaries, and genetic engineering of model organisms are opening new vistas for exploring the brain and how it works.

A heating and freezing process known as dual thermal ablation can kill pancreatic cancer cells, according to new research from Binghamton University, State University at New York.

Combining genetics, live - imaging, laser ablation and computer simulations, we aim to analyze whether distinct or similar mechanisms can account for the common role of tumor suppressors and proto - oncogenes in cell - cell contact regulation.

We are currently employing our new genetic tools for mast cell - specific inactivation of loxP - flanked genes and for inducible ablation of mature mast cells in adult animals to clarify the roles mast cells play in neoplastic disease.

Experimental approach: To use patient - specific induce pluripotent cell models from a (i) storage disease (NCL), (ii) aggregate prone disease (ALS) and (iii) a disease with no aggregates but hyperexcitability (ChAc) combined with state of the art live cell imaging techniques, electrophysiology and biophysical tools (PIV, laser ablation for cortex tension measurements, AFM).

C: the green line shows the attenuation of optical fluence in scattering tissue relative to the PNB thresholds for normal and prostate cancer (PC) cells, the difference between these thresholds determines an effective radius of PNB - based selective ablation of prostate cancer cells.

A loss of Vγ4 + Ccr6 + cells was also observed following CD169 + macrophage ablation using CD169 - DTR mice (Figure 7F).

Using conditional genetic ablation of Ar in Sertoli cells, we have shown that AR signaling is required for three stages of spermatogenesis: progression through meiosis I, the differentiation of haploid round spermatids into elongating spermatids, and spermiogenesis, the release of fully differentiated elongated spermatids into the lumen of the seminiferous epithelium.

a) In the subsection «Cell type - specific NMDA - R pharmacology in cocaine - induced synaptic plasticity» we now more clearly introduce the Zweifel and Engblom studies as well as the differences between them: both of which used genetic ablation of Grin1 over 1 week but showed different results with respect to DA neuron synaptic potentiation, which was due to methodological challenges with AMP - R compensation.

Genetic ablation of a Na + / H + exchanger (NHE2), which is expressed in the stomach at high levels, leads to a decrease in gastric acid secretion, along with decreased viability of parietal cells, severe metaplasia, and hyperplasia of gastric mucosa.