Sentences with phrase «cell adhesion»

Dr. Zutter focuses on the role of cell adhesion molecules in host - tumor interactions.

We capitalized on one of the innate responses of microvascular endothelial cells, i.e., the up - regulation of cell adhesion molecules in response to inflammatory agents, to generate endothelial cell lines from different organs.

Structures of water channels AQP0 and AQP4 were analyzed by electron crystallography and appear to play a role in cell adhesion in addition to water channel functions.

In vivo imaging of endothelial cell adhesion molecule expression after radiosurgery in an animal model of arteriovenous malformation.

One of the earliest events in the development of atherosclerosis is the recruitment of inflammatory white blood cells from the blood to the arterial wall by vascular cell adhesion molecules (42).

As a doctoral student in the lab of Drs. Margaret Wheelock and Keith Johnson at the University of Toledo, Dr. Islam focused on identifying a link between cadherins (a family of cell adhesion proteins) and tumorigenesis (start of cancer cell formation).

The team studied a protein in the brain called neural cell adhesion molecule 2, or NCAM2 — one of a family of molecules that physically connects the membranes of synapses and help stabilise these long lasting synaptic contacts between neurons.

The study also points to a potentially new therapeutic target, the self - adhesion molecule P - selectin, which the researchers found played a central role in increased red blood cell adhesion.

Interaction between CD4 and class II MHC molecules mediates cell adhesion.

Researchers found that histatin - 1 promotes angiogenesis, as well as cell adhesion and migration.

They found that human lung cancer samples with high levels of beta - arrestin - 1 also had high levels of proteins associated with cell adhesion and motility.

January 21, 2000 Cell - cell adhesion process For the first time, researchers at the University of Chicago describe in detail how neighboring skin cells adhere to one another to form sealed barriers.

Taken together, these results strongly suggest that the LPA2 signaling modulates T cell motility in the confined environments at least partly in an integrin - independent manner and may also act on cell adhesion to prevent over-adhesion to the substrates.

Rescue of this defect was due to proper localization and function of GFP - NMHC II - A in place of NMHC II - B in a cell - cell adhesion complex in the cells lining the spinal canal.

Our final review article, from the labs of Maximilian Boesch (Kantonsspital St. Gallen, Switzerland) and Andreas Seeber (Medical University of Innsbruck, Austria), provides an update on the role of epithelial cell adhesion molecule (EpCAM) in cancer stem cells (CSCs) and the epithelial ‐ to ‐ mesenchymal transition (EMT) in colorectal cancer (CRC).

Talin1 depletion impaired cancer cell adhesion to the endothelium and transendothelial migration, resulting in reduced liver metastasis formation in vivo.

Cells can fail to stick together sufficiently, referred to as reduced cell adhesion, or they can stick together normally but not respond in the correct way to that contact, referred to as a loss of contact inhibition.

This growth is associated with a down - regulation in the sensory neuron of Aplysia cell adhesion molecules (apCAMs).

Dscam, which stands for Down syndrome cell adhesion molecule, likely helps guide the developing connections between cells early in life.

Dr. Weitzman's research career has focused on understanding cancer progression by studying cell adhesion, signal transduction and epigenetic mechanisms that contribute to tumor phenotypes.

As described below, however, the LPA / LPA2 axis appears to affect T cell adhesion on the surfaces coated with LFA -1-ligand or fibronectin.

GAG (glycosaminoglycans) are common constituents of cell surfaces and extracellular matrices, and their interactions with a wide variety of molecules such as growth factors and cytokines play a prominent role in basic biological phenomena like cell adhesion, migration, proliferation and differentiation.

In a new study, NAIST scientists, in collaboration with researchers at the Osaka National Hospital and University of Tokyo, report that the L1 Cell Adhesion Molecule (L1 - CAM) is crucial for directed axon migration.

from cell adhesion to cell migration and polarity: the division's mission is the comprehension of pathological phenomena at a cellular and molecular level, fundamental to cure disease and foster biotechnology research.

Nanoscale architecture of integrin - based cell adhesions.

The release of inflammatory cytokines, or intercellular signaling molecules such as interleukin - 1 (IL - 1), interleukin - 2 (IL - 6), and tumor necrosis factor alpha (TNF - α) at the site of immune activation causes other immune cells migrating throughout the lymphatic vessels of the body to express more cell adhesion molecules (CAMs).

Prominent among these were promoters affecting pathways that control cell adhesion and axon guidance.

They not only support cells and cell layers, but also play an essential role in tissue organization that affects cell adhesion, migration, proliferation, and differentiation.

«It is possible that therapeutically targeting plakoglobin or pathways involved in cell - to - cell adhesion within cancer cells could be clinically useful, especially in patients in whom CTC clusters are found,» says Nicola Aceto, PhD, of the MGH Cancer Center and lead author of the Cell paper.

Neuronal cell - glial cell adhesion was inhibited by prior incubation of the neurons with Fab» fragments of antibodies to neuronal membranes.

«We can incorporate cell adhesion or degradation sites to recruit cells or draw in different components from native tissue.»

Research groups in Munich, Essen, and Brussels have now detected a highly specific and exceptionally strong variant of this adhesion, in which the bacterial surface molecule HopQ binds itself to so - called «Carcinoembryonic Antigen - Related Cell Adhesion Molecules,» or CEACAMs for short, inside the stomach.

They coat the pad with a layer of anti-epithelial cell adhesion molecules (anti-EpCAM) which bond with CTCs but not with normal cells.

For instance, Georgia Tech Graduate Student Ricardo Cruz - Acuña, the paper's co-lead author, experimented with several combinations before determining that a hydrogel made up of 96 percent water and containing a particular cell adhesion peptide was ideal for the HIOs.

In the face of low oxygen levels, or hypoxia, cell adhesion increased significantly in the nitric oxide - deficient mice.

When they restored normal nitric oxide levels by having mice breathe in the short - lived gas — as patients have done in clinical trials — cell adhesion did not increase when oxygen levels decreased.

More of the antibodies that coat the nanorod can therefore bind receptors on the surface of endothelial cells, and that leads to more effective cell adhesion and more effective drug delivery.

This week at the Biophysical Society 59th annual meeting, being held Feb. 7 - 11, 2015 in Baltimore, Md., University of Illinois biophysicists are reporting a new picture of cell adhesion mechanics they liken to a famous Hans Christian Andersen fairy tale.

He carried out his postdoctoral research at the Dana - Farber Cancer Institute, Harvard Medical School in Boston in the US, working on integrin cell adhesion molecules.

In the case of cancer, ineffective cell adhesion allows tumour cells to detach and invade other tissues, thereby spreading cancer throughout the body.

This study highlights that cell adhesion results not only from the formation of a cadherin - catenin - actin complex, but from the activity of more than 500 interacting proteins.

The resulting endothelial cell lines described in this study retain their phenotype after repeated passage, require minimal nutritional support and, importantly, may be useful for identifying factors that regulate endothelial cell proliferation and tumor cell adhesion in different anatomical regions.

We used experimental data to validate the core assumptions of the model framework, which permitted us to make predictions for a broad set of ecological scenarios defined by the intensity of environmental flow, surface colonization density, cell adhesion properties, and the dimensions of the colonized surface.

This research helped to show that insulin resistance in vascular endothelial cells can create a pro-inflammatory state marked by the heightened presence of certain cell adhesion proteins that make immune cells stick to endothelial cells, the first step in enabling the immune cells to travel from the blood stream to tissues.

IGFBP5 induces cell adhesion, increases cell survival and inhibits cell migration in MCF - 7 human breast cancer cells.

In spite of its putative importance, we have a limited understanding of how flow, surface colonization processes, and cell adhesion interact to influence the spatial strain structure of nascent bacterial communities.