Sentences with phrase «cell adhesion molecules in»

Programs with research emphasis on signal transduction in development and oncogenesis, cell adhesion molecules in development and oncogenesis, muscologskeletal atrophy and countermeasures, ovarian follicle development, neural regeneration, implantable therapeutic or diagnostic devices and application of computers in veterinary education.

61/3: 00 Rare copy number variants implicate neuronal cell adhesion molecules in Tourette Syndrome.

Dr. Zutter focuses on the role of cell adhesion molecules in host - tumor interactions.

We capitalized on one of the innate responses of microvascular endothelial cells, i.e., the up - regulation of cell adhesion molecules in response to inflammatory agents, to generate endothelial cell lines from different organs.

This rapid, transmitter - mediated down - regulation of a cell adhesion molecule in the sensory neurons may be one of the early molecular changes in long - term synaptic facilitation.

Expression of the melanoma cell adhesion molecule in human mesenchymal stromal cells regulates proliferation, differentiation, and maintenance of hematopoietic stem and progenitor cells.

Not exact matches

This drug (vedolizumab) blocks a specific adhesion molecule on the surface of the T - cell and thereby inhibits immune cells from binding themselves to receptors present in the intestine, preventing the T - cells from penetrating the blood vessels in the intestinal tissue.

They lie in a region of chromosome 5 that sits squarely between two genes that produce cell - adhesion molecules, which govern how neurons connect to each other.

In contrast, antibodies to the neural cell adhesion molecule (N - CAM) did not inhibit the binding.

In a new study, NAIST scientists, in collaboration with researchers at the Osaka National Hospital and University of Tokyo, report that the L1 Cell Adhesion Molecule (L1 - CAM) is crucial for directed axon migratioIn a new study, NAIST scientists, in collaboration with researchers at the Osaka National Hospital and University of Tokyo, report that the L1 Cell Adhesion Molecule (L1 - CAM) is crucial for directed axon migratioin collaboration with researchers at the Osaka National Hospital and University of Tokyo, report that the L1 Cell Adhesion Molecule (L1 - CAM) is crucial for directed axon migration.

Research groups in Munich, Essen, and Brussels have now detected a highly specific and exceptionally strong variant of this adhesion, in which the bacterial surface molecule HopQ binds itself to so - called «Carcinoembryonic Antigen - Related Cell Adhesion Molecules,» or CEACAMs for short, inside the adhesion, in which the bacterial surface molecule HopQ binds itself to so - called «Carcinoembryonic Antigen - Related Cell Adhesion Molecules,» or CEACAMs for short, inside the Adhesion Molecules,» or CEACAMs for short, inside the stomach.

This growth is associated with a down - regulation in the sensory neuron of Aplysia cell adhesion molecules (apCAMs).

The study also points to a potentially new therapeutic target, the self - adhesion molecule P - selectin, which the researchers found played a central role in increased red blood cell adhesion.

The neural cell adhesion molecule, N - CAM, appears on early embryonic cells and is important in the formation of cell collectives and their boundaries at sites of morphogenesis.

Now a more fine - grained picture of adhesion mechanics is emerging, thanks to a new tool developed in Illinois in recent years called a «tension gauge tether,» which allows scientists to measure cell mechanics at the single - molecule level.

«This finding reveals cells» ultra-sensitivity for strong single molecule forces in the environment during adhesions,» Roein - Peikar noted.

They found a gene — dubbed Dscam (Down syndrome cell adhesion molecule)-- that appears to give every nerve cell a unique identity during prebirth development, making sure that each cell ends up in the right location in the brain and body.

Cells migrate by connecting their cytoskeleton — a network made up of proteins — to adhesion molecules which in turn get in contact with the surrounding connective tissue.

A small percentage of ASD patients carry mutations in genes encoding neuroligins, which are postsynaptic cell - adhesion molecules.

However, Professor Auguste's team, discovered the overexpression of intercellular adhesion molecule - 1 (ICAM - 1) in human TNBC cell lines and tissues, and demonstrated that it is a potential molecular target and biomarker for TNBC therapy and diagnosis.

The selection strategy targeted cell populations expressing the inducible endothelial cell adhesion molecules, E-selectin and VCAM - 1, and proved successful in generating microvascular endothelial cell lines from a number of different organs.

The endothelial cells in insulin - receptor knockout mice expressed more of the VCAM - 1 adhesion molecule that helps white blood cells grab onto the growing plaques, and blood vessels gathered four times as many white blood cells.

Timothy Springer, with colleagues Michael L. Dustin and Charles A. Dinarello, identifies and characterizes adhesion molecules, a class of cell surface proteins that function in the interactions of immune cells with other cells, including antigen - specific recognition and cell trafficking: integrin LFA - 1 involved in cytoskeleton and signaling, and intracellular adhesion molecules (ICAMs), which are binding partners (ligands) for LFA - 1 and are increased in inflammatory and autoimmune disease.

In vivo imaging of endothelial cell adhesion molecule expression after radiosurgery in an animal model of arteriovenous malformatioIn vivo imaging of endothelial cell adhesion molecule expression after radiosurgery in an animal model of arteriovenous malformatioin an animal model of arteriovenous malformation.

They will then examine other mouse models with mutations involved in cell - adhesion and extracellular matrix molecules for signs of RPE diseases.

Endothelial cell specific adhesion molecule (ESAM) localizes to platelet — platelet contacts and regulates thrombus formation in vivo.

Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells.

Increased expression of Cd11b - a marker of macrophages [38] seen with L - arginine admininistration in WNIN / Gr - Ob rats, might be due to increased influx of inflammatory cells in the exocrine fraction via adhesion molecules [17].

Other studies have shown that a family of proteins called 14 -3-3 are involved in learning along with interesting cell adhesion molecules of the integrin family and the immunoglobulin superfamily.

Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting

Our final review article, from the labs of Maximilian Boesch (Kantonsspital St. Gallen, Switzerland) and Andreas Seeber (Medical University of Innsbruck, Austria), provides an update on the role of epithelial cell adhesion molecule (EpCAM) in cancer stem cells (CSCs) and the epithelial ‐ to ‐ mesenchymal transition (EMT) in colorectal cancer (CRC).

Contactin genes CNTN5 and CNTN6 code for neuronal cell adhesion molecules that promote neurite outgrowth in sensory - motor neuronal pathways.

Studies cover a breadth of topics ranging from single molecules (molecular motors, DNA - protein interactions, membrane proteins) to cellular functions (cell adhesion, cell division, cell motility, intracellular transport) and the collective behaviour of cells in tissues and organisms (wound healing, morphogenesis).

We therefore conducted a cross-sectional analysis to investigate the relations between magnesium intake and plasma concentrations of inflammatory and endothelial biomarkers, including CRP, IL - 6, soluble TNF - α receptor 2 (sTNF - R2), E-selectin, soluble intercellular adhesion molecule 1 (sICAM - 1), and soluble vascular cell adhesion molecule 1 (sVCAM - 1) in apparently healthy women.

In a cell - culture study, polyunsaturated fats did not alter TNF - α — mediated up - regulation of the adhesion molecules ICAM - 1, VCAM - 1, and E-selectin (34).

A recent in vitro study showed that incorporating a greater extent (2-fold) of TFA in the phospholipid fraction of endothelial cells significantly increased the expression of endothelial adhesion molecules, including ICAM - 1 (25).

In addition to the niacin it supplies, brown rice may also help raise blood levels of nitric oxide, a small molecule known to improve blood vessel dilation and to inhibit oxidative (free radical) damage of cholesterol and the adhesion of white cells to the vascular wall (two important steps in the development of atherosclerotic plaquesIn addition to the niacin it supplies, brown rice may also help raise blood levels of nitric oxide, a small molecule known to improve blood vessel dilation and to inhibit oxidative (free radical) damage of cholesterol and the adhesion of white cells to the vascular wall (two important steps in the development of atherosclerotic plaquesin the development of atherosclerotic plaques).

Two molecules that are known to increase during inflammatory disease processes — vascular cell adhesion molecule - 1 (VCAM - 1) and intercellular adhesion molecule 1 (ICAM - 1)-- have also been shown to decrease in amount following intake of EVOO.

Resveratrol has been found to inhibit the expression of adhesion molecules in cultured endothelial cells (43, 44).

One of the earliest events in the development of atherosclerosis is the recruitment of inflammatory white blood cells from the blood to the arterial wall by vascular cell adhesion molecules (42).