As a doctoral student in the lab of Drs. Margaret Wheelock and Keith Johnson at the University of Toledo, Dr. Islam focused on identifying a link between cadherins (a family of
cell adhesion proteins) and tumorigenesis (start of cancer cell formation).
Aiolos decreases the production of
cell adhesion proteins and disrupts critical cell adhesion processes, including processes that allow tissue cells to anchor to their physical environment, a necessary requirement for cells to survive and spread.
Not exact matches
Henikoff told Malik about his work with
proteins — histones — that attach to the central regions of chromosomes — centromeres — during
cell division, maintaining
adhesion between chromosomes most of the time, but also playing a role when the chromosomes are pulled apart to prepare them for duplication.
The results show that distinct genetic profiles underlie specific memory processes: The study reports, for example, associations between a transporter
protein set and the process of learning as well as between a
cell adhesion set and the process of memory storage.
The
protein, known as focal
adhesion kinase, or FAK, activates an enzyme called AKT, which helps islet
cells in the pancreas to survive.
A vaccine under development prevents
adhesion proteins at the tips of spaghettilike pili on UTI - causing bacteria (left) from latching onto host
cells.
The groundbreaking study identified a
protein, known as cadherin - 22, as a potential factor in cancer metastasis, or spread, and showed that hindering it decreased the
adhesion and invasion rate of breast and brain cancer
cells by up to 90 per cent.
The stress hormone treatment activated a
protein called FAK (focal
adhesion kinase), which is known to protect
cells from anoikis.
Cells migrate by connecting their cytoskeleton — a network made up of
proteins — to
adhesion molecules which in turn get in contact with the surrounding connective tissue.
Researchers at the Mechanobiology Institute have comprehensively described the network of
proteins involved in
cell -
cell adhesions, or the cadherin interactome.
Interestingly, the researchers found that most of the
proteins that associated with E-cadherin did so independently of
cell -
cell adhesion.
Once the bacterial
cell signaling
protein cagA reaches the host cytosol, it is capable of altering subsequent generations of progenitor
cells, leading to the development of cancer through changes in mitotic activity, apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA
protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial
adhesion with gastric epithelial
cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.
Timothy Springer, with colleagues Michael L. Dustin and Charles A. Dinarello, identifies and characterizes
adhesion molecules, a class of
cell surface
proteins that function in the interactions of immune
cells with other
cells, including antigen - specific recognition and
cell trafficking: integrin LFA - 1 involved in cytoskeleton and signaling, and intracellular
adhesion molecules (ICAMs), which are binding partners (ligands) for LFA - 1 and are increased in inflammatory and autoimmune disease.
Upregulated genes clustered into at least 7 functional groups, including immediate early genes or transcription factors,
cell - cycle related genes, stress - responsive
protein genes,
cell signaling
protein genes,
cell adhesion and
cell surface
protein genes, genes involved in translation and
protein turnover, and genes encoding metabolic
proteins.
ARHGAP21
Protein, a New Partner of α - Tubulin Involved in
Cell -
Cell Adhesion Formation and Essential for Epithelial - Mesenchymal Transition.
A study has shown that the immunosuppressive effect of MSCs is mediated by the secretion of galectin - 3, a
protein known to modulate T
cell proliferation, gene expression,
cell adhesion and migration 44.
Endocytosis regulates
cell soma translocation and the distribution of
adhesion proteins in migrating neurons.
Cannabinoid inhibits HIV - 1 Tat - stimulated
adhesion of human monocyte - like
cells to extracellular matrix
proteins.
The work has led him to explore the role of
protein phosphorylation in a diverse array of cellular functions, including transformation,
cell communication,
cell adhesion,
cell - cycle regulation, the control of gene expression, and
protein degradation.
Association of an A-kinase-anchoring
protein signaling scaffold with cadherin
adhesion molecules in neurons and epithelial
cells.
The alpha actinin (ACTN) family
proteins are actin - binding
proteins that regulate cytokinesis,
cell adhesion, spreading, migration and signaling to control
cell function.
N2 supplement, which contains transferrin, was used in the presence of antibody to minimize the possibility that antibody
protein non-specifically modified
cell - substrate from
adhesion and therefore neurite outgrowth.
The
protein is involved in
cell -
cell adhesion.
Other studies have shown that a family of
proteins called 14 -3-3 are involved in learning along with interesting
cell adhesion molecules of the integrin family and the immunoglobulin superfamily.
For example, new combinations of domains in death-fold domain
proteins and laminins possibly allow for the modification of
protein interactions and pathways involved in programmed
cell death and
cell adhesion, respectively (Supplementary Note 9.3), and the co-option of sponge -, eumetazoan - or bilaterian - specific architectures into novel functions.
Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated
protein kinase; APP, amyloid precursor
protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B -
cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent
protein kinase kinase β; CHMP2B, charged multivesicular body
protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting
protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding
protein - 1; Epac, exchange
protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal
adhesion kinase family - interacting
protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating
protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem
cell; hVps, mammalian vacuolar
protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13
protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal
protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related
protein kinase; PINK1, PTEN - induced kinase 1; PKA,
protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding
protein; raptor, regulatory - associated
protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment
protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane
protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar
protein sorting
Genome - wide association studies have identified associations between body mass index and two loci near
cell adhesion molecule 1 (CADM1) and
cell adhesion molecule 2 (CADM2), which encode membrane
proteins that mediate synaptic assembly.
Studies cover a breadth of topics ranging from single molecules (molecular motors, DNA -
protein interactions, membrane
proteins) to cellular functions (
cell adhesion,
cell division,
cell motility, intracellular transport) and the collective behaviour of
cells in tissues and organisms (wound healing, morphogenesis).
[6]
Proteins are also important in
cell signaling, immune responses,
cell adhesion, active transport across membranes, and the
cell cycle.
Plc is a clinical stage biotechnology company, which focuses on the discovery, development and commercialization of novel antibodies for the potential treatment of diseases that involve
protein misfolding or
cell adhesion.