Sentences with phrase «cell aggregates formed»

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If the necessary ribosome - associated quality control machinery (RQC) does not function properly, defective proteins accumulate and form toxic aggregates in the cytoplasm of the cells.

Once CAT - tailed proteins are imported into the mitochondria, they form aggregates that may act as a seed, and ultimately bind proteins free of defects that have vital roles for the cell» explains Toshiaki Izawa, first author of the study, together with Sae - Hun Park.

Scientists have long suspected that Alzheimer's patients lose their memories and their wits when amyloid beta proteins form needlelike aggregates that punch holes in brain cells and kill them.

But this form of tissue regeneration does not occur in humans, so the researchers recreated similar conditions in the laboratory by growing human cells as 3D aggregates.

«We began thinking that maybe if we could get the human cells to aggregate like the mouse cells, that might be a step toward getting them to form new follicles,» Christiano says.

«Our results not only demonstrate a potential mechanism for the development of neurodegenera - tive disorders but we have also found another example of the way in which proteins can form aggregates and damage the cell.

«If Ltn1p is not active in pathologically modified cells or if other components of quality control are missing, defective proteins accumulate and form aggregates in cell interiors,» says Park.

While typically thought of as solitary life forms, microbes frequently aggregate to form dense cell clusters.

Gorfe's computer simulations showed Ras proteins cluster together, or form aggregates, on the cell membrane.

Previously, researchers have shown that treating cells with neuregulin - 1, for example, dampens levels of amyloid precursor protein, a molecule that generates amyloid beta, which aggregate and form plaques in the brains of Alzheimer's patients.

Protein aggregates that form after a cell is exposed to high, non-lethal temperatures appear to be part of an organized response to stress, and not the accumulation of damaged proteins en route to destruction.

Then, in some fatal cases, the fungal filaments began to grow in the brain, attracting platelets and white and red blood cells to aggregate around the filaments and form a mass that could block a blood vessel and initiate a stroke.

Groups of stem cells stick together as they develop, forming multicellular aggregates that form spheroids as they grow.

After a two - day culture period, liver cells formed tightly packed cellular aggregates, called spheroids, and took on a liver - like appearance.

Embryoid bodies (EB) are the three - dimensional aggregates formed in suspension by pluripotent stem cells (PSC), including embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC).

However, while V − S + cells generated normal EBs, the V+S + cells formed small irregular aggregates (Figure 8B), suggesting that the adhesive properties of the cells within these fractions were different.

New research explains how the protein TDP43 normally concentrates into droplets and how ALS - related mutations disrupt that, leading to them to form more problematic aggregates that afflict cells.

September 10, 2015 Protein aggregation after heat shock is an organized, reversible cellular response Protein aggregates that form after a cell is exposed to high, non-lethal temperatures appear to be part of an organized response to stress, and not the accumulation of damaged proteins en route to destruction.

In the last 3 years Gormley has been experimenting with cell aggregates of nesting polyhedra in both solid and space - frame forms turning the space of the body into an open framework of tetrahedral, cubic, dodecahedral and more complex polygons which, in his words, «achieved a breakthrough when released from a bounding skin.»