Sentences with phrase «cell aggregates of»

In the last 3 years Gormley has been experimenting with cell aggregates of nesting polyhedra in both solid and space - frame forms turning the space of the body into an open framework of tetrahedral, cubic, dodecahedral and more complex polygons which, in his words, «achieved a breakthrough when released from a bounding skin.»

Not exact matches

(1) human life (2) animal life (3) vegetable life (4) single living cells (5) large scale inorganic aggregates of occasions (6) energy - events disclosed by modern physics

Yet they are not mere aggregates of cells.

«Thinking machines» are made of microchips, wires and the like, all of which are aggregates of molecules as contrasted with individual entities that constitute a brain — namely brain cells that are composite individuals.

These «aggregates» can comprise hundreds of thousands of cells, be up to 2 mm in diameter and be eight times more resistant to chemotherapy drugs — firstly because hypoxic conditions are created inside the aggregates and secondly because these tumour cells reduce growth and are therefore less sensitive.

«Large aggregates of ALS - causing protein might actually help brain cells: UNC School of Medicine scientists add to evidence that small aggregates of SOD1 protein are the brain - cell killing culprits in ALS, but the formation of larger, more visible, and fibril - like aggregates of the same protein may protect brain cells.»

Left: cells with large, fibril - like aggregates of SOD1 protein.

Mochly - Rosen and colleagues identified several other potential biomarkers that were elevated in HD model mice, including the levels of 8 - hydroxy - deoxy - guanosine, a product of oxidative DNA damage, in the urine and the presence of mutant huntingtin aggregates and oxidative damage in muscle and skin cells.

If the necessary ribosome - associated quality control machinery (RQC) does not function properly, defective proteins accumulate and form toxic aggregates in the cytoplasm of the cells.

A common feature of neurodegenerative diseases such as Alzheimer's, Parkinson's or Huntington's disease are deposits of aggregated proteins in the patient's cells that cause damage to cellular functions.

In order to get rid of these toxic aggregates, cells have developed an elaborate protein quality control system, which the researchers now describe in the journal Cell.

Once CAT - tailed proteins are imported into the mitochondria, they form aggregates that may act as a seed, and ultimately bind proteins free of defects that have vital roles for the cell» explains Toshiaki Izawa, first author of the study, together with Sae - Hun Park.

To determine how aggregates can arise in mitochondria and cause damage to cells, they cooperated with the team led by F. - Ulrich Hartl at the Max Planck Institute of Biochemistry.

It may be that what we call our self, or the «I» in our perception of self, is made not of patterns of electrochemical synaptic logic (neurons chattering) but rather the aggregate experience of the mass of glial cells, each one contributing its particle of consciousness to the whole.

But this form of tissue regeneration does not occur in humans, so the researchers recreated similar conditions in the laboratory by growing human cells as 3D aggregates.

Within a few days, the multiplying cells self - aggregate into tiny balls of neural tissue.

This aggregate of organisms and other substances that surround them makes it difficult for both drugs and immune cells to reach the bacteria.

«We found that the worms and human cells were almost completely protected from the Huntington's aggregates when we turned on this response,» said Andrew Dillin, the Thomas and Stacey Siebel Distinguished Chair in Stem Cell Research in UC Berkeley's Department of Molecular and Cell Biology and a Howard Hughes Medical Institute investigator.

The background image shows a picture of the nematode C. elegans with clumps of the Huntington's aggregates (bright green because they're tagged with green fluorescent protein) in the body wall muscle cells.

Most significantly, microscopy showed that nuclei of ASF1 - depleted cells contained aggregates of telomeric DNA, known as PML bodies.

«Our results not only demonstrate a potential mechanism for the development of neurodegenera - tive disorders but we have also found another example of the way in which proteins can form aggregates and damage the cell.

«If Ltn1p is not active in pathologically modified cells or if other components of quality control are missing, defective proteins accumulate and form aggregates in cell interiors,» says Park.

The cell culture experiments showed that MAbs prevented the uptake of misfolded α - syn fibrils by neurons and sharply reduced the recruitment of natural α - syn into new Lewy body aggregates.

While typically thought of as solitary life forms, microbes frequently aggregate to form dense cell clusters.

To capture only the effects of agricultural productivity on conflict rather than the opposite, the analysis incorporates the role of droughts using the Standardized Precipitation Index, which aggregates monthly precipitation by cell year.

«It's the same process as for single cell genomics, but for aggregates of symbiotic bacteria and archaea,» said DOE JGI Microscale Applications Group head Rex Malmstrom of the technique called BONCAT - FACS (BONCAT — Fluorescence - Activated Cell Sorticell genomics, but for aggregates of symbiotic bacteria and archaea,» said DOE JGI Microscale Applications Group head Rex Malmstrom of the technique called BONCAT - FACS (BONCAT — Fluorescence - Activated Cell SortiCell Sorting).

Previously, researchers have shown that treating cells with neuregulin - 1, for example, dampens levels of amyloid precursor protein, a molecule that generates amyloid beta, which aggregate and form plaques in the brains of Alzheimer's patients.

«We're sorting individual aggregates full of cells that are active in a simulated environment and with the cell sorter we can grab active cells to study them.

Sara Calafate: «We noticed that the spread of Tau aggregates, a typical characteristic of Alzheimer's, proceeded much more effectively via interconnecting brain cells.

A new in vitro model Scientists developed a new research tool for this study that enabled them to monitor the spread of Tau aggregates whilst changing the synaptic connections between brain cells.

The scientists, Nicole King and Arielle Woznica of the University of California, Berkeley, with collaborators Jon Clardy and J.P. Gerdt at Harvard Medical School in Boston, discovered that within minutes after exposure to a chonodroitin sulfate (CS) lyase produced by V. fischeri, S. rosetta cells aggregate into mass mating swarms, entering into cell and nuclear fusion while duplicating and recombining their genetic material.

Andrey Lavrov and Igor Kosevich, MSU biologists, researched the ability of the cells of marine sponges (Porifera) to reaggregation — a process, during which the artificially separated sponge cells reaggregate and build multicellular aggregates of varying types.

In addition to determining that protein aggregation is regulated and requires active translation, Stowers scientists revealed that the mitochondria, the cell's powerhouses, play a key role in the mobility of these protein aggregates.

The main result of our study is a detailed description of the cell reaggregation process dynamics, and also of the structure of multicellular aggregates of the marine sponges belonging to the Demospongiae class,» explains Andrey Lavrov.

Protein aggregates that form after a cell is exposed to high, non-lethal temperatures appear to be part of an organized response to stress, and not the accumulation of damaged proteins en route to destruction.

«Remarkably, the majority of aggregates present in the mother cell did not follow the mitochondria that entered the bud, but they either underwent dissolution or remained associated with the mitochondria that were kept in the mother cell and only exhibited confined local mobility,» describes Li.

«In contrast to what's been observed in many studies on foreign proteins and mutant cells, disassembly of native aggregates after heat shock in normal cells is essentially complete under these conditions,» Drummond said.

The team are now working to better understand the biological functions of the aggregates, particularly in their roles as regulators of cell function.

After creating stem cell aggregates with microparticles containing different growth factors, the researchers observed a hemispherical organization of cells for several days, with the different cells remaining spatially segregated.

Groups of stem cells stick together as they develop, forming multicellular aggregates that form spheroids as they grow.

«We can then put the microparticle materials physically inside the multicellular aggregate system that we use for differentiation of the stem cells.

The research builds on the team's previous work with a technique called three - dimensional culture, which involves incubating stem cells in a floating ball - shaped aggregate, unlike traditional cell culture in which cells grow in a flat layer on the surface of a culture dish.

Longino argues that the commonsense value of «simplicity» in scientific reasoning sometimes stands for a preference for — or an ability only to imagine — linear hierarchical theories, such as the theory that slime mold aggregates because of special pacemaker cells that rule the other cells in the mold.

Researchers are now reporting advances in these areas by using gelatin - based microparticles to deliver growth factors to specific areas of embryoid bodies, aggregates of differentiating stem cells.

In the past, scientists have tried to isolate so - called auditory stem cells from embryoid bodie — aggregates of stem cells that have begun to differentiate into different types.

Interestingly, isolated islets provide a superior platform for studying propagation of IAPP aggregates because islets retain the composition and organization of endocrine cells and the extracellular matrix, which is absent in isolated, cellular monolayers.

These aggregates resembled the macrophage syncytia characteristic of chronic inflammatory states such as rheumatoid arthritis and foreign body giant cell induction (47 — 49).

In our studies, we observed hyperglycemia and impaired glucose tolerance in the Tg - hIAPP mice treated with IAPP aggregates, which occurred concomitant to a significant loss of β cells (> 60 %).

The results showed that Tg - hIAPP injected with pancreatic homogenate containing IAPP aggregates (the Tg / Tg group) exhibited an altered islet morphology characterized by the appearance of α - and δ - cells in the center of the islets, compared with the classical pattern in mice (observed in Tg / WT), in which these cells are mostly confined to the periphery of the islets (Brissova et al., 2005).

Intriguingly, brain cells (neurons) with decreased complex I levels are significantly less likely to contain Lewy bodies, the abnormal protein - aggregates that characterize Parkinson's disease,» says researcher Charalampos Tzoulis at Department of Clinical Science, UiB.