Sentences with phrase «cell aggregates with»

Treatment of cell aggregates with sodium vanadate in the presence of LIF has been shown to repress Nanog and stimulate PrEn differentiation [40].

After creating stem cell aggregates with microparticles containing different growth factors, the researchers observed a hemispherical organization of cells for several days, with the different cells remaining spatially segregated.

Not exact matches

«Thinking machines» are made of microchips, wires and the like, all of which are aggregates of molecules as contrasted with individual entities that constitute a brain — namely brain cells that are composite individuals.

Left: cells with large, fibril - like aggregates of SOD1 protein.

Once CAT - tailed proteins are imported into the mitochondria, they form aggregates that may act as a seed, and ultimately bind proteins free of defects that have vital roles for the cell» explains Toshiaki Izawa, first author of the study, together with Sae - Hun Park.

To determine how aggregates can arise in mitochondria and cause damage to cells, they cooperated with the team led by F. - Ulrich Hartl at the Max Planck Institute of Biochemistry.

These protein aggregates — called Huntington's aggregates — have been linked to problems with the repair system that nerve cells rely on to fix proteins that fold incorrectly: the cell's so - called protein folding response.

«The Lewy bodies are big aggregates and they're sitting in the cell, but they don't come into direct contact with the mitochondria in the way pα - syn * does,» Lasmézas explains.

The background image shows a picture of the nematode C. elegans with clumps of the Huntington's aggregates (bright green because they're tagged with green fluorescent protein) in the body wall muscle cells.

Previously, researchers have shown that treating cells with neuregulin - 1, for example, dampens levels of amyloid precursor protein, a molecule that generates amyloid beta, which aggregate and form plaques in the brains of Alzheimer's patients.

«We're sorting individual aggregates full of cells that are active in a simulated environment and with the cell sorter we can grab active cells to study them.

These abnormal proteins are prone to aggregating with one another inside cells.

The scientists, Nicole King and Arielle Woznica of the University of California, Berkeley, with collaborators Jon Clardy and J.P. Gerdt at Harvard Medical School in Boston, discovered that within minutes after exposure to a chonodroitin sulfate (CS) lyase produced by V. fischeri, S. rosetta cells aggregate into mass mating swarms, entering into cell and nuclear fusion while duplicating and recombining their genetic material.

«Remarkably, the majority of aggregates present in the mother cell did not follow the mitochondria that entered the bud, but they either underwent dissolution or remained associated with the mitochondria that were kept in the mother cell and only exhibited confined local mobility,» describes Li.

The research builds on the team's previous work with a technique called three - dimensional culture, which involves incubating stem cells in a floating ball - shaped aggregate, unlike traditional cell culture in which cells grow in a flat layer on the surface of a culture dish.

In our studies, we observed hyperglycemia and impaired glucose tolerance in the Tg - hIAPP mice treated with IAPP aggregates, which occurred concomitant to a significant loss of β cells (> 60 %).

The results showed that Tg - hIAPP injected with pancreatic homogenate containing IAPP aggregates (the Tg / Tg group) exhibited an altered islet morphology characterized by the appearance of α - and δ - cells in the center of the islets, compared with the classical pattern in mice (observed in Tg / WT), in which these cells are mostly confined to the periphery of the islets (Brissova et al., 2005).

Intriguingly, brain cells (neurons) with decreased complex I levels are significantly less likely to contain Lewy bodies, the abnormal protein - aggregates that characterize Parkinson's disease,» says researcher Charalampos Tzoulis at Department of Clinical Science, UiB.

Thus, our results strongly suggest that substantial loss of β cells is the likely cause of the diabetic phenotype in the animals treated with IAPP aggregate - containing materials.

Those doses were chosen in analogy with the prion field, in which it is very common to observe that 1 % and 0.1 % tissue homogenate containing prion protein aggregates is able to induce pathological changes both in cell culture experiments and in in vivo animal models.

In the group of mice treated with synthetic IAPP aggregates, we observed a substantial reduction in the area of islets occupied by β cells as compared with controls untreated or treated with the same concentration of nonaggregated IAPP (Fig. 7 D).

[13] AN1792 was an active vaccine, with Aβ aggregates as the antigen, and the meningoencephalitis is postulated to have been the result of the vaccine having roused a T - cell response against Aβ along with the necessary B - cell response, leading to a Th1 - biased inflammatory attack centralized on sites in the brain with local Aβ deposits.

By sweeping away AS aggregates before they get a chance to spread, AS immunotherapies have the potential to hold the nonmotor symptoms of PD at bay, slowing the overall progress of the disease, and — when combined with mature cell therapy — eventually preventing the disease altogether, and potentially even reversing it.

Their work builds upon and may potentially supersede several previous approaches to the problem of mitochondrial mutations that occur as a result of the degenerative aging process, including allotopic protein expression, (6) its optimization using an MTS, (3 - 5) and the exploitation of the multiprotein RNA import complex (RIC) of the protozoal parasite Leishmania tropica (7)(which the investigators characterize as «requir [ing] the introduction of nonnative tRNAs with foreign protein factors or the transfer of a large multisubunit aggregate into cells, which is of low efficiency and difficult to reproduce in desirable disease - relevant settings» (2)-RRB-.

This hematoxylin and eosin stained slide of a surgically removed (resected) primary pancreatic tumor shows a cluster of immune cells (lymphoid aggregate) observed next to a pancreatic tumor lesion in a patient treated with a GM - CSF vaccine 2 weeks before surgical removal of the primary tumor.

Although PFIR does not work with liquid samples, says Xu, it can measure the properties of dried biological samples, including cell walls and protein aggregates, achieving a 10 - nm spatial resolution without staining or genetic modification.

To eliminate the possibility of any undifferentiated cells in the cultures accounting for this observation, DMSO - differentiated cells were treated with the anti-proliferative agent cytosine arabinosidase (Ara - C), starting two days after aggregate plating.

Experimental approach: To use patient - specific induce pluripotent cell models from a (i) storage disease (NCL), (ii) aggregate prone disease (ALS) and (iii) a disease with no aggregates but hyperexcitability (ChAc) combined with state of the art live cell imaging techniques, electrophysiology and biophysical tools (PIV, laser ablation for cortex tension measurements, AFM).

Clint continued to develop the Splinter Cell franchise as Lead Level Designer, Scriptwriter, and Creative Director on SPLINTER CELL: CHAOS THEORY - the highest rated Splinter Cell to date with an aggregate review score of 9Cell franchise as Lead Level Designer, Scriptwriter, and Creative Director on SPLINTER CELL: CHAOS THEORY - the highest rated Splinter Cell to date with an aggregate review score of 9CELL: CHAOS THEORY - the highest rated Splinter Cell to date with an aggregate review score of 9Cell to date with an aggregate review score of 94 %.

In the last 3 years Gormley has been experimenting with cell aggregates of nesting polyhedra in both solid and space - frame forms turning the space of the body into an open framework of tetrahedral, cubic, dodecahedral and more complex polygons which, in his words, «achieved a breakthrough when released from a bounding skin.»

What's interesting to me is that the survey, which is carried out for the various phone companies in Canada, measured land line only, cell phone only, but not cable of VOIP only, reporting instead on the aggregate cable or VOIP use with and without the use of other phone types.