Sentences with phrase «cell aging suggests»

Even though Wnt proteins are difficult to manipulate, their ability to reverse intestinal stem cell aging suggests a pathway that clinicians may eventually be able to target.

Not exact matches

«It was the older meditators who had brains that seemed particularly well preserved, suggesting that meditation provides protection against the brain cell loss associated with aging,» notes the BPS.

The act of reprogramming cells to make them as capable as ones from embryos apparently can result in aberrant cells that age and die abnormally, suggesting there is a long way to go to prove such cells are really like embryonic stem cells and can find use in therapies.

Recent studies suggest that the total loss in brain volume due to atrophy — a wasting away of tissue caused by cell degeneration — between our teen years and old age is 15 percent or more, which means that by the time we're in our seventies, our brains have shrunk to the size they were when we were between 2 and 3 years old.

The work, which appeared in Cell Reports on January 2, 2018, suggests that astrocytes may be good therapeutic targets to prevent or reverse the effects of normal aging.

The results indicate that beta cell function does not decline with age, and instead suggest that islet function is threatened by an age - dependent impairment of vessels that support them with oxygen and nutrients,» says Per - Olof Berggren at the Rolf Luft Research Center for Diabetes and Endocrinology at Karolinska Institutet, who led the study together with Alejandro Caicedo at University of Miami Miller School of Medicine and Hong Gil Nam at DGIST in Republic of Korea.

«Although such differences may be a function of the large sample size and thus not clinically relevant, our findings suggest that use of ICSI may improve fertilization rates but not implantation or pregnancy rates in the setting of unexplained infertility, advanced maternal age, and low oocyte [a cell from which an egg develops] yield,» the authors write.

While changes in insulin secretion are unlikely to play a major role in the acute effects of SD, cellular stress in pancreatic tissue suggests that chronic SD may contribute to the loss or dysfunction of endocrine cells, and that these effects may be exacerbated by normal aging, say the researchers.

But Finch's results suggested instead that cells and genes in aged mammals function no differently from those in younger animals, given the right physiological milieu — in this case, a sufficient dose of glucocorticoids.

Pancreas tissue from acutely sleep - deprived aged animals exhibited a marked increase in CHOP, a protein associated with cell death, suggesting a maladaptive response to cellular stress with age that was amplified by sleep deprivation.

Some have proposed that age - associated inflammation is caused by accumulating wear and tear on our immune cells, while others have suggested that it is caused by immune cells dealing with chronic viral infections.

NO BARRIER A protein in some cells that form the blood - brain barrier (light blue, as seen in this image of a mouse brain capillary) may have a hand in brain aging, a new study suggests.

«There's clearly a strong link between aging and stem cell renewal, and this paper went a long way towards suggesting that a circulating factor could play a role.»

Earlier studies suggested the possible involvement of these support cells in ALS development and progression, but the new research is believed to be the first to directly measure the effects of aging on the ability of astrocytes to sustain motor neurons.

But a recent report that her telomeres — the tips of chromosomes, which tend to shrink as cells grow older — are shorter than normal for her age suggests that her life span might be reduced.

Evidence from the study suggests that old age decline is related to cells losing the ability to generate energy in the form of ATP.

«These results suggest that inflammation in mid-life may be an early contributor to the brain changes that are associated with Alzheimer's disease and other forms of dementia,» said study author Keenan Walker, PhD, of Johns Hopkins University School of Medicine in Baltimore, Md. «Because the processes that lead to brain cell loss begin decades before people start showing any symptoms, it is vital that we figure out how these processes that happen in middle age affect people many years later.»

Evidence suggests that the resolution of infection and thus inflammation is prolonged due to reduced clearance of apoptotic cells and debris by macrophages.11 These age - associated alterations in innate immunity may contribute to increased systemic inflammation termed «inflamm - ageing» observed in aged tissues.10

«Our study shows that this unique stem cell - based retinal implant thus far is well - tolerated, and preliminary results suggest it may help people with advanced dry age - related macular degeneration,» says coauthor and lead inventor of the implant Dr. Mark S. Humayun, MD, director of the USC Institute for Biomedical Therapeutics, co-director of the USC Roski Eye Institute, affiliate principal investigator with the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC and university professor of ophthalmology at the Keck Schcell - based retinal implant thus far is well - tolerated, and preliminary results suggest it may help people with advanced dry age - related macular degeneration,» says coauthor and lead inventor of the implant Dr. Mark S. Humayun, MD, director of the USC Institute for Biomedical Therapeutics, co-director of the USC Roski Eye Institute, affiliate principal investigator with the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC and university professor of ophthalmology at the Keck SchCell Research at USC and university professor of ophthalmology at the Keck School.

This research has been suggested before using cell cultures and in artificially aged mice, but this is the first time that a naturally - aging model has been used.

Their findings on telomeres, the stretches of DNA at the ends of chromosomes that protect our genetic code and make it possible for cells to divide, suggest a potential target for preventive measures against cancer, aging and other diseases.

These findings suggest that RPE cells, derived from iPS cells, could be used to treat blindness in humans, such as blindness caused by age - related macular degeneration, a leading cause of blindness in the Western world.

Cells with similar characteristics accumulate during normal aging as well as in younger persons infected with human immunodeficiency virus, suggesting that the process of replicative senescence is not an artifact of cell culture but is also occurring in vivo.

IRP and low - grade inflammation predicted 57 % of observed deaths and 97 % of survival over 2 years, and was not significantly affected by individuals» health status, suggesting that the physiological ageing processes of T - cell immunosenescence and low - grade inflammation are of primary importance in late life survival.

These discoveries suggest that increased cell - to - cell transcriptional variability will be a hallmark feature of aging across most, if not all, mammalian tissues.

It was even lower in the early lesions of I10 mice than in those of age - matched virgin mice, suggesting that the molecular network activated in normal epithelia at involution to arrest the cell cycle (Figure 1 — figure supplement 3B) also operates in these premalignant cells.

The findings suggest that inadequate sleep in the elderly, who normally experience sleep disturbances, could exacerbate an already - impaired protective response to protein misfolding that happens in aging cells.

This suggests the importance of zinc in the normal and pathological processes of the cerebral cortex.37 Furthermore, age - related tissue zinc deficiency may contribute to brain cell death in Alzheimer's dementia.38

First proposed in 1972, the mitochondrial theory of aging suggests that it's free radical damage to our cells» power source, known as mitochondria, that leads to a loss of cellular activity and function over time.

The mitochondrial theory of aging suggests that free radical damage to our cells» power source (mitochondria) leads to a loss of cellular energy and function over time.

See, muscles can become smaller and weaker with age (a process known as sarcopenia), and evidence suggests that a key part of the decline occurs in this mitochondria, a component of muscle cells that is the ultimate powerhouse — the primary engine of energy production.

The adage «out with the old and in with the new» could help prevent age - related diseases if applied to certain cells, suggests a study on mice, published in the journal Nature in November 2011.

Furthermore, there is evidence suggesting an association of replication stress on rDNA loci with the aging of hematopoietic stem cells, adding more evidence to the general function of the nucleolus in genome integrity and aging.

This research suggests that antioxidants help decrease levels of free radicals which can damage cells and cause aging.

ERG abnormalities are evident by 5 — 6 weeks of age and cell degeneration is present by 4 months, suggesting the mutant protein has a toxic gain of function that severely compromises the early stage of development of the photoreceptors.

• What would be convincing: Bear in mind that these authors argue against the usefulness of our meta - analysis by suggesting that the sex difference only emerges in one cell of what would be a 16 - cell design — the «young - age - long - term - relationship - third - party - coder - ratings - control - variables - accounted - for» cell.