Sentences with phrase «cell analyses on»

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Our proprietary algorithm can predict cells with high genomic instability and identifies an HRD phenotype based on image analysis alone.

With proper repetitions, negative controls and statistical analyses, the effects of carrageenan exposure on human cells can be better understood.

When similar analysis was performed on the db mice, it was found that the disrupted db gene was responsible for encoding a protein that functions as a leptin receptor: When it binds circulating leptin at the cell surface, it sets in motion a biochemical cascade inside the cell.

A further issue is that tracking mutations through bulk analysis of cells is typically based on certain assumptions as to how mutations arise and what their frequencies mean.

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Y. Ning et al., Genetic analysis of indefinite division of human cells: Evidence for a cell senescence - related gene (s) on human chromosome 4.

Eager to sort through the pile of curriculum vitae's on his desk, Rudnicki is particularly looking for molecular geneticists working on different stem cell systems; scientists with genomics bents like proteomics, microarray analysis, and bioinformatics; and a couple of clinician scientists.

Based on the little eyewitness information they could collect, Charlottesville police in 2003 started approaching dark - skinned men with a request for what some call get - lucky swabs — swipings from the inner cheeks of nonsuspects to collect cells for DNA analysis.

The NB activity in Alberta is far ranging, with such research as self - assembled nanostructures (M. J. Brett), single - cell cancer analysis (L. M. Pilarski), computational modeling (D. Wishart), micro-total analysis systems or lab on a chip (D. J. Harrison), cell identification and manipulation (K. Kaler), and microsystems and medical diagnostics (Backhouse).

The centre will be structured around six technical platforms focusing on zebrafish transgenesis and micromanipulation, bioimaging, mouse transgenesis, flow cytometry, stem cell culture, and gene - expression analysis.

Biochemist Radhey Gupta of McMaster University in Canada proposes that a bacterium and an archaean fused to form the first eukaryote, based on his analysis of a pair of slow - changing genes found in what may be one of the oldest cells with a nucleus, Giardia lamblia.

Their analysis focused on the substantia nigra, a brain structure where Parkinson's disease kills neurons that use the chemical dopamine to communicate with other cells.

«Lenalidomide maintenance following autologous stem cell transplant can now be considered a standard of care for people with multiple myeloma,» says Dr. McCarthy, senior author on the meta - analysis and Principal Investigator of the U.S. study, CALGB (Alliance) 100104.

The finding, reported by a Stand Up to Cancer - Prostate Cancer Foundation Dream Team in the May 21 edition of the journal Cell, is based on an analysis of tumor samples from 150 men with metastatic prostate cancer that no longer responded to standard hormone - blocking therapy.

Tests rely on either expensive equipment for computer - assisted analysis or, in hospitals that can not afford thousands of dollars» worth of machinery, a technician who analyzes sperm cells under a microscope, a process Shafiee says can be subject to human error.

Biomolecular model based on the gene expression data analyses support the reduction of glucose molecules (blue gradient) and acid buildup (gold gradient) proposed to occur in the boundary layer around the cell.

Those analyses have long relied on qualitative changes in cell shape to track physiological shifts.

The work, which was propelled by technologies that enable the detailed analysis of even a handful of cells, opens a critical window on the biology of the disease and suggests a strategy for the development of more precise, powerful treatments.

Chemical analysis showed that its structure resembled that of a protein found on T cells.

This analysis, done on separate samples from the same patient, revealed that many of the affected genes confer advantages to cancer cells by, for example, enhancing cell migration or resistance to chemotherapy.

A multicenter team of researchers reports that a full genomic analysis of tumor samples from a small number of people who died of pancreatic cancer suggests that chemical changes to DNA that do not affect the DNA sequence itself yet control how it operates confer survival advantages on subsets of pancreatic cancer cells.

They measured 17 metabolites from 8 different phthalate parent compounds in that sample, then performed DNA methylation analyses on sperm cells to examine statistical associations.

The researchers will measure phthalates in the men's urine sample, then perform DNA methylation analyses on sperm cells and look for a statistical association between these measures as well as sperm quality and embryo development.

The approach, called metabolomic analysis, provides a «chemical snapshot» that pictures in great detail what is going on within cells at a specific stage.

The DNA analysis used in this study focused on mitochondrial DNA, which is easier to recover from fossils than the DNA in chromosomes, because each cell has thousands of copies of the relatively short mitochondrial DNA sequence.

«Adipose analysis on microfluidic chips: Platform works with minute quantities of liquid to grow cells and study their development.»

He has worked in the biotech industry as a research scientist for over 11 years with a focus on emerging technologies including gene targeting in mice, molecular analysis of transgenes using GFP variants at the single cell level, and developing flow cytometry reagent kits to speed up assay development time for researchers.

As part of ENCODE, 32 institutions did computer analyses, biochemical tests, and sequencing studies on 147 cell types — six fairly extensively — to find out what each of the genome's 3 billion bases does.

Based on an analysis of existing evidence, published in an opinion article in the Nature Reviews Clinical Oncology journal on January 20, Dr. Narod argues that to achieve a cure, rather than simply delay progression or reoccurrence of the disease, women should be first treated with aggressive surgery to remove all clinically - detectable cancer cells, followed by targeted chemotherapy to the abdomen (intraperitoneal chemotherapy).

To capture only the effects of agricultural productivity on conflict rather than the opposite, the analysis incorporates the role of droughts using the Standardized Precipitation Index, which aggregates monthly precipitation by cell year.

In addition, the analysis provided some hints about how chemotaxis evolved from a simple signaling network that responds slowly to environmental cues — primarily by turning on genes — to a multiprotein system that can quickly alter a cell's course.

«Intracellular signaling depends on these protein modifications — so by doing these analysis, we know not only what's in the cell, but also how the cell organizes and communicates internally.»

For example, cell culture or biological analysis, which are conducted in biology laboratories, can be performed on a microfluidic chip.

Based on meta - analysis of over 100 studies of transmembrane cell - surface receptors, as well as his own research, Prof. Maruyama proposed a new model for receptor activation — the «rotation model.»

To bypass the challenge, the team relied on their complementary expertise in genome engineering, stem cell differentiation into neurons, and genomic analysis of alternative splicing.

Research fields are diverse, including basic research on cell proliferation, analysis of tumour cells and tissues to detect gene mutations, and identification of potential therapeutic targets in cancer.

In the new vision — based on increasingly sophisticated genetic analyses — people and other animals are closer cousins to single - celled choanoflagellates than to other multicellular organisms.

Researchers at the University of Edinburgh and the MRC Laboratory for Molecular Biology in Cambridge used molecular analysis to find that concentrations of magnesium rose and fell in a 24 - hour cycle in all cell types, and that this impacts on the cells» internal clocks.

The team then performed comprehensive RNA sequencing on the blood samples followed by computational data analyses to determine what genes and cells were activated and driving these allergic reactions.

Two new analyses of the male sex chromosome have concluded that its genes have vital, wide - reaching effects on every cell in the body

In this report, Bradamante and colleagues examined endothelial cells in real microgravity aboard the International Space Station and conducted deep gene expression and protein analysis on the cells.

A whole series of experiments based on two - photon microscopy, electrophysiology and behavioural analyses have shown that Tm cells are activated specifically by «light OFF» brightness changes.

Dogs» special relationship to humans may go back 27,000 to 40,000 years, according to genomic analysis of an ancient Taimyr wolf bone reported in the Cell Press journal Current Biology on May 21.

Now, genetic analysis of the cells has cast fresh doubts on the research and found potential evidence of inadvertent or deliberate switching of cellular material.

Based on analyses of over 600 drug and breast cancer cell pairings, researchers showed that, for some cells, drug exposure can cause significant changes in gene expression — indicating the successful action of a drug on its target — without affecting cell growth or survival.

The microfluidic device designed by his team captures cells based on their distinct internal structure — a mechanical analysis instead of the blood chemistry analysis used in conventional medical diagnostic techniques.

Cells were analyzed on a FACSCalibur and analysis was performed using CellQuest software (Becton, Dickinson and Co., Franklin Lakes, New Jersey, USA).

Individual profiles based on the analysis of each patient's tumor cells revealed clinically relevant information that could be used to prioritize the drugs most likely to be effective in these cases.

One of the first analyses of laws banning disposal of electronic waste (e-waste) in municipal landfills has found that state e-waste recycling bans have been mostly ineffective, although California's Cell Phone Recycling Act had a positive impact on cell phone recyclCell Phone Recycling Act had a positive impact on cell phone recyclcell phone recycling.

Using an antibody that recognizes the CD68 antigen we performed immunohistochemical analysis on these human samples and calculated the percentage of CD68 expressing cells (Figure 9).