Sentences with phrase «cell analysis reveals»
46/3: 15 Single - cell analysis reveals that endogenous retrotransposons generate somatic mosaicism in neuronal and non-neuronal cells.
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Zena Werb, University of California, San Francisco, USA Single - cell analysis reveals a stem - cell program in human metastatic breast cancer cells.
«Nature, meet nurture: Single - cell analysis reveals diverse landscape of genetic changes in the brain after a sensory experience.»
Not exact matches
I won't reveal yet who my favorites are, but I will say that these young scientist - founders came up with very creative solutions for preventing infections in some common surgeries, tackling resistance in targeted antibody drugs, improving gene vectors for cell therapies, helping the vision - impaired «see» faces and better read their environments, imaging hard - to - see spots in the lungs and other organs, improving genetic risk analysis, and expediting the logistical operations of hospitals.
An in - depth genetic analysis, performed with the participation of graduate students Tal Lupo and Lihee Asaf, pointed to a gene called WNT5B, which was revealed to be the factor prompting stem cells to differentiate into lymphatic cells.
The analysis revealed that the human genome is organized into large pieces of low or high epigenetic stochasticity, and that these regions correspond to areas of chromosomes that are structurally different in the cell nucleus.
An analysis of the HPV16 genome from 5,570 human cell and tissue samples revealed that the virus actually consists of thousands of unique genomes, such that infected women living in the same region often have different HPV16 sequences and variable risks to cancer.
«Our analysis revealed that the differences between tame and aggressive foxes may lie in cells in the anterior pituitary gland, which can change their shapes to communicate with one another about when it's time to release stress hormones,» Hekman said.
Information theory analysis of cell signaling reveals mechanisms for reliable cellular responses despite signal variability.
Further analysis of the genes that had been stimulated in the responders revealed that they were involved in immune cell function relevant to the inflammatory disease process in RA.
Additional analysis revealed that ChABC gene therapy changed the way that inflammatory cells in the region respond following injury.
A separate analysis of 3BNC117 by Ching - Lan Lu et al. reveals that the antibody not only blocks infection of new cells, but accelerates the clearance of infected cells as well.
This analysis, done on separate samples from the same patient, revealed that many of the affected genes confer advantages to cancer cells by, for example, enhancing cell migration or resistance to chemotherapy.
Expression analyses revealed that these genes are active almost exclusively in testicular germ cells, where, at a minimum, they likely contribute to sperm production.
Chromatin immunoprecipitation sequencing analysis revealed enrichment of H3K27me3 at specific loci in KDM6A - null cells, including PRC2 / EZH2 and their downstream targets.
Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.
Simultaneous T cell antigen receptor (TCR) analysis in single cells and bulk subsets revealed that CD4 - TEMRA cells show marked clonal expansion compared with TCM and TEM cells and that most of CD4 - TEMRA were dengue virus (DENV)-- specific in donors with previous DENV infection.
«Gene analysis adds layers to understanding how our livers function: Tracking gene expression patterns for 20,000 gene in 1,500 cells revealed a mosaic of activities.»
Recent advances in our understanding of cancer have revealed that the disease can not be understood through simple analysis of genetic mutations within the cancerous cells.
Recent advances in our understanding of cancer have revealed that the disease can not be understood through simple analysis of genetic mutations within cancerous cells.
Analyses of RV144 volunteers revealed that particular vaccine - induced immune responses, including production of certain antiviral antibodies and CD4 + T cell responses to HIV's outer shell, or envelope, correlate with reduced HIV infection.
The analysis performed revealed that many variations in immune cell function triggered by chronic HIV infection are associated with high levels of bNAbs.
«Single - cell analysis of embryos reveals mis - segregation of parental genomes.»
New genetic analyses of tropical marine microorganisms have revealed that some species of single - celled plankton are converting significant amounts of nitrogen from the air into nutrients, helping to fortify the base of the ocean's food pyramid.
An analysis revealed three distinct types of cell phone users: low - use extroverts, low - use introverts and a high - use group.
«Our analysis revealed that terminal acid shock was not completely lethal to the yeast's cells, although nearly a third of the yeast died in some experiments,» Bochman said.
Targeting the labeled cells for analysis, they revealed that their organoids contained a population of sensory cells that have the same functional signature as cells that detect gravity and motion in the human inner ear.
Analysis of the trajectories of people carrying cell phones reveals that human mobility patterns are highly predictable.
Additional analyses revealed that stem cells were also smaller, had a higher nucleus - to - cytoplasm ratio, and were less viscous than mature cells.
Analysis of the most aggressive of these cells revealed a pattern of gene expression distinct from that known to occur in breast - to - bone metastasis, as described in an earlier paper by Massagué.
A major component of the study was a comprehensive analysis of the «phosphoproteome» of prostate cancer tumors and cells, revealing changes in the phosphorylation states of cellular proteins.
To begin to explore the cellular mechanisms that might be responsible for this response, histological analysis revealed less severe disruption of spermatogenesis and gene expression studies suggested that an interplay of ATP - binding cassette (ABC) efflux transporters and solute carrier (SLC) influx transporters in the testicular cells might be involved.
Individual profiles based on the analysis of each patient's tumor cells revealed clinically relevant information that could be used to prioritize the drugs most likely to be effective in these cases.
The treatment induced changes in the synthesis of 101 proteins and ELISA analysis revealed a sixfold higher secretion of type II collagen compared to control cells.
X-ray studies at the Department of Energy's SLAC National Accelerator Laboratory, combined with Stanford biological studies and computational analysis, revealed remarkable similarities in the structure of binding sites, which allow a given T cell to recognize many different invaders that provoke an immune response.
Further analysis revealed that the mice in Tg / Tg group, which developed severe hyperglycemia, lost > 75 % of their β cells compared with WT mice of the same strain and similar age.
The results of our microRNA (miRNA) profile analysis for these cells revealed that CSCs that are highly metastatic to bone and brain expressed significantly lower level of miR - 7 and that this miRNA was capable of modulating one of the essential genes for induced pluripotent stem cell, KLF4.
A proteomics analysis revealed expression changes of 56 proteins, and a further protein pathway analysis suggested their association with the cell morphology, the organization, and the increased cellular movement and the proliferation.
Immunohistochemical analysis of perigonadal, perirenal, mesenteric, and subcutaneous adipose tissue revealed that the percentage of cells expressing the macrophage marker F4 / 80 (F4 / 80 +) was significantly and positively correlated with both adipocyte size and body mass.
Proteomic analysis of arginine methylation sites in human cells reveals dynamic regulation during transcriptional arrest.
Molecular analyses revealed that some of the former regulatory T cells had become follicular helper T cells (Tfh).
A deep - sequencing analysis reveals that non-malignant skin cells harbor many more cancer - driving mutations than previously expected.
Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells.
Flow cytometric analysis revealed that anti-Thy 1.2 antibody plus complement depleted > 97 % of the Thy 1.2 + cells (data not shown).
St. Jude Children's Research Hospital analysis reveals how the protein p53, which triggers cancer cells to commit suicide, attaches to its regulatory molecule; findings could lead to drugs to unleash p53 to battle a range of cancers.
Analysis of mEPSC properties in SPNs revealed a significant decrease in mEPSC frequency only in iSPNs from 6 - month old Q175 mice, with no genotypic differences in mEPSC amplitude in either cell type.
Additional cellular analysis revealed a subset of these bacterial proteins that were secreted into the host cytoplasm independent of the known Salmonella mechanisms for transporting virulence proteins into host cells
Early in vitro analyses of gene expression revealed that the cell lines were germ - cells, our target cell type.
Analysis of gene expression array in TSC2 - deficient AML cells reveals IRF7 as a pivotal factor in the Rheb / mTOR pathway.
Mats Nilsson demonstrated a unique technology to reveal cells harboring specific mutations in tissue sections, while Ruedi Aebersold held an impressive lecture, illustrating about how powerful mass spectrometry provides a basis for for computational analyses, commented moderator Ulf Landegren.