Sentences with phrase «cell analysis with»

-- Combining the detailed information from existing single cell analysis with our in situ sequencing method can be powerful and find great use in both research and diagnostics, says Mats Nilsson.

Not exact matches

I won't reveal yet who my favorites are, but I will say that these young scientist - founders came up with very creative solutions for preventing infections in some common surgeries, tackling resistance in targeted antibody drugs, improving gene vectors for cell therapies, helping the vision - impaired «see» faces and better read their environments, imaging hard - to - see spots in the lungs and other organs, improving genetic risk analysis, and expediting the logistical operations of hospitals.

Our proprietary algorithm can predict cells with high genomic instability and identifies an HRD phenotype based on image analysis alone.

With proper repetitions, negative controls and statistical analyses, the effects of carrageenan exposure on human cells can be better understood.

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An in - depth genetic analysis, performed with the participation of graduate students Tal Lupo and Lihee Asaf, pointed to a gene called WNT5B, which was revealed to be the factor prompting stem cells to differentiate into lymphatic cells.

Analysis showed that within the moss protonema cells, more that 85 % of the lead had accumulated in the cell walls, with smaller amounts being found in organelle membranes and inside the chloroplasts where photosynthesis occurs.

In cancer research, our goal is to be able to start with a sample of human tissue, extract many cells of interest, and perform genetic analysis upon each of them separately.

Eager to sort through the pile of curriculum vitae's on his desk, Rudnicki is particularly looking for molecular geneticists working on different stem cell systems; scientists with genomics bents like proteomics, microarray analysis, and bioinformatics; and a couple of clinician scientists.

Based on the little eyewitness information they could collect, Charlottesville police in 2003 started approaching dark - skinned men with a request for what some call get - lucky swabs — swipings from the inner cheeks of nonsuspects to collect cells for DNA analysis.

The NB activity in Alberta is far ranging, with such research as self - assembled nanostructures (M. J. Brett), single - cell cancer analysis (L. M. Pilarski), computational modeling (D. Wishart), micro-total analysis systems or lab on a chip (D. J. Harrison), cell identification and manipulation (K. Kaler), and microsystems and medical diagnostics (Backhouse).

«Our analysis revealed that the differences between tame and aggressive foxes may lie in cells in the anterior pituitary gland, which can change their shapes to communicate with one another about when it's time to release stress hormones,» Hekman said.

Biochemist Radhey Gupta of McMaster University in Canada proposes that a bacterium and an archaean fused to form the first eukaryote, based on his analysis of a pair of slow - changing genes found in what may be one of the oldest cells with a nucleus, Giardia lamblia.

What the rover can do is detect the building blocks for those cells with its portable chemistry lab, Sample Analysis at Mars.

Their analysis focused on the substantia nigra, a brain structure where Parkinson's disease kills neurons that use the chemical dopamine to communicate with other cells.

Isoflavones have been shown to slow the growth of breast cancer cells in laboratory studies, and epidemiological analyses in East Asian women with breast cancer found links between higher isoflavone intake and reduced mortality.

The new platform processes hundreds to tens of thousands of cells per day, providing scalable, sensitive, single - cell sequencing with simple yet powerful data analysis.

For this analysis, 605 patients with newly diagnosed multiple myeloma and treated with continuous lenalidomide (brand name Revlimid) following autologous stem cell transplant were compared to 604 patients who were treated with placebo or no maintenance.

«Lenalidomide maintenance following autologous stem cell transplant can now be considered a standard of care for people with multiple myeloma,» says Dr. McCarthy, senior author on the meta - analysis and Principal Investigator of the U.S. study, CALGB (Alliance) 100104.

The tool acts with surgical precision to replace only abundances that have most likely dropped out and can be used in any type of single - cell gene - expression analysis.

The finding, reported by a Stand Up to Cancer - Prostate Cancer Foundation Dream Team in the May 21 edition of the journal Cell, is based on an analysis of tumor samples from 150 men with metastatic prostate cancer that no longer responded to standard hormone - blocking therapy.

Two months after therapy, tissue analysis showed less scarring and higher levels of regenerative agents such as fibroblast growth factor — which accelerate healing — in rats treated with SIS plus stem cells compared with those treated with SIS alone.

Spearheaded by first author Christopher McNair, PhD, a graduate student in the laboratory of Dr. Knudsen, the study undertook an extensive analysis of tumor samples and cell - free DNA samples from patients with advanced, lethal - stage prostate cancer.

Labs have started tackling the problem with a tool called single - cell transcriptome analysis, which gives readouts of all the genes that are active in individual cells.

To unravel the complex signaling pathway map, the scientists used their own findings from the analysis of factors regulated up or down in the interplay between tissue and stem cells, linking them with the signaling pathways described in existing literature.

The analysis of charges at more than 150 California hospitals looked at blood tests that are often required of patients, such as lipid panel, basic metabolic panel, and complete blood cell count with differential white cell count.

Protein immunoblot and histochemical analysis with antiserum to type I NO synthase suggest that the formation of NO in pancreatic B cells is catalyzed by an NADPH -(reduced form of nicotinamide adenine dinucleotide phosphate), Ca2 + / calmodulin - dependent type I NO synthase of about 150 kilodaltons.

With current techniques it is not easy to make comparative analysis of influenza viruses with single mutations in their genomes, and it is extremely difficult to identify factors that limit the reassortment process between two influenza genomes that have infected the same cWith current techniques it is not easy to make comparative analysis of influenza viruses with single mutations in their genomes, and it is extremely difficult to identify factors that limit the reassortment process between two influenza genomes that have infected the same cwith single mutations in their genomes, and it is extremely difficult to identify factors that limit the reassortment process between two influenza genomes that have infected the same cell.

«Adipose analysis on microfluidic chips: Platform works with minute quantities of liquid to grow cells and study their development.»

Intravital two - photon bone imaging is superior compared with conventional analyses of the shape and form of a tissue because it enables two - dimensional scanning in bone in a focal plane to observe cell shapes and the appearance of mOBs and mOCs in the body.

The profile of CD4 - TEMRA was highly heterogeneous across donors, with four distinct clusters identified by the single - cell analysis.

Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.

«By combining the genetic analysis of a small population of immune cells from healthy skin with functional experiments we were able to define two subgroups of memory immune cell and in detail decipher / dissect how these cells behave in healthy and inflamed skin,» explains Liv Eidsmo, researcher at Karolinska Institutet's Department of Medicine.

Simultaneous T cell antigen receptor (TCR) analysis in single cells and bulk subsets revealed that CD4 - TEMRA cells show marked clonal expansion compared with TCM and TEM cells and that most of CD4 - TEMRA were dengue virus (DENV)-- specific in donors with previous DENV infection.

Visualization of the 3 - D microscopy data together with the analysis results is a key step to measure and ultimately understand what drives these cells.»

Immunofluorescence analysis of prostate cancer cells treated with 15mM flutamide, 35?

He has worked in the biotech industry as a research scientist for over 11 years with a focus on emerging technologies including gene targeting in mice, molecular analysis of transgenes using GFP variants at the single cell level, and developing flow cytometry reagent kits to speed up assay development time for researchers.

Analyses of RV144 volunteers revealed that particular vaccine - induced immune responses, including production of certain antiviral antibodies and CD4 + T cell responses to HIV's outer shell, or envelope, correlate with reduced HIV infection.

The analysis performed revealed that many variations in immune cell function triggered by chronic HIV infection are associated with high levels of bNAbs.

Based on an analysis of existing evidence, published in an opinion article in the Nature Reviews Clinical Oncology journal on January 20, Dr. Narod argues that to achieve a cure, rather than simply delay progression or reoccurrence of the disease, women should be first treated with aggressive surgery to remove all clinically - detectable cancer cells, followed by targeted chemotherapy to the abdomen (intraperitoneal chemotherapy).

Adds Liu: «With metastatic cancers accounting for around 90 % of deaths from solid tumors, the hope is that one day a device that can enable the analysis of single tumor cells circulating in the blood could make a big difference in early diagnosis, detection and monitoring of numerous types of cancer, without invasive biopsies.»

In the study, analysis of patient samples demonstrated that high LSC17 scores meant poor outcomes with current standard treatment, even for patients who had undergone allogeneic stem cell transplantation.

In the lab, the scientific team used an approach that combined functional RNAi analysis with gene expression analysis in breast cancer - derived cell lines and in human breast cancers replicated in mice.

The role of rebiopsy and repeat analysis in the setting of post-treatment relapse, along with testing of blood samples for mutations in circulating tumor cells, cell free tumor DNA, or exosomes will be considered.

Using a very sensitive DNA analysis technique that can also be employed when only very small amounts of DNA from old tissue are available, the researchers could compare the two current cell lines with the tumor from which the cell line was established.

A series of biological analyses of the mice with Tim - 1 and immune cells isolated from human donors showed that Ebola virus directly binds to T - cells through Tim - 1 protein binding and causes massive inflammation that thwarts the immune system.

Their analysis showed that the diversity of T - cell receptors decreased among samples of T - cells taken closer to the tumor, compared with farther away.

A University of Colorado Cancer Center study published in the journal Oncogene used next - generation sequencing technologies to perform the most detailed DNA - based analysis to date of 25 commonly used bladder cancer cell lines, allowing researchers to match patient tumors with their closest genetic cell line match, and demonstrated genetic alterations that may make cells more or less sensitive to common therapies.

The Norwegian analysis was done after researchers at Harvard University found these effects of the medicines in animal tests and in experiments with brain cells in the lab.

«Our combined analysis of cell - free DNA and white blood cell DNA allows for identification of tumor DNA with much higher sensitivity, and deep sequencing also helps us find those rare tumor DNA fragments.»