The Innovator Award will enable Sipkins to continue to combine state - of - the - art imaging techniques, performed on living mice, with
cell and molecular biology approaches to learn more about these stem cell niches.
Not exact matches
Earlier, for his Ph.D., he used his physics training to study biological interactions at the
molecular resolution — but for his postdoc he changed
approaches dramatically, turning to
cell biology and applying his skills to the development of high - resolution functional imaging of DNA transcription in living
cells.
These are at length / time scales intermediate between the CHEMICAL
BIOLOGY AND BIOPHYSICS IRG and the MOLECULAR APPROACHES TO CELL FUNCTIONS AND INTERACTIONS I
AND BIOPHYSICS IRG
and the MOLECULAR APPROACHES TO CELL FUNCTIONS AND INTERACTIONS I
and the
MOLECULAR APPROACHES TO
CELL FUNCTIONS
AND INTERACTIONS I
AND INTERACTIONS IRG.
His laboratory uses a multidisciplinary
approach encompassing systems
biology,
molecular pharmacology, biochemistry / proteomics,
cell and structural
biology,
and computation / bioinformatics.
His current research uses a variety of
molecular, biochemical,
and genetic
approaches to study the basic
biology of mesenchymal stem
cells (MSCs).
Using a combination of
molecular biology, biochemical
and novel multi-dimensional digital imaging
approaches we study in real - time complex multi dimensional signal integration during the interaction of T
cells with live antigen - presenting
cells.
In our interdisciplinary
approach, we combine
cell and molecular biology,
molecular genetics, biophysical tools including laser microsurgery, optical engineering, computer science
and theoretical physics.
The broad area of
molecular,
cell and developmental
biology is a rapidly growing area that has deeply impacted modern biological
approaches.
Her laboratory has successfully combined electrophysiological expertise with
molecular and cell biology approaches to better understand complex mechanisms underlying the memory process in mouse models of AD.
Objective: To use innovative
approaches of integrative
biology to unravel how lymphocytes process an array of
molecular signals arising from contact with dendritic
cells, thereby better understanding the mechanisms that underlie immunity
and how they are altered in disease states.
The lab investigates consequences of epigenetic alterations in neuronal cancers
and neurodegenerative diseases using a combination of biochemistry,
cell and molecular biology with genome wide
approaches to gain mechanistic insight into how chromatin architecture is modified in disease.
We discovered several Eph receptors
and ephrins,
and research in our laboratory is dedicated to the characterization of Eph receptor signal transduction mechanisms
and biological functions using biochemical, mass spectrometry,
molecular biology and cell biology approaches in conjunction with animal models.
We use a combination of conditional mouse models, primary
cell culture (human
and mouse), live microscopy, highthroughput genomics
and proteomics
approaches,
and basic
molecular biology.
Coinciding with CIRM's goals, three of the floors planned for renovation will accommodate the collaborative work of top stem
cell researcher
and UCSB professor James Thompson, who was the first to isolate human embryonic
cells in 1998; the new Mellichamp
and Ruth Garland Chairs of bioengineering
and molecular mechanisms, respectively;
and the «Deep Sequencing Core,» which will house, among other things, a device that will help develop new genetic
approaches to important
cell biology inquiries.