In a xenograft KMT2D - mutated T - lymphoma model, dual treatment with chidamide and decitabine significantly retarded tumor growth and induced
cell apoptosis through modulation of the KMT2D / H3K4me axis.
Not exact matches
PAK proteins allow melanoma to thrive
through their action on a few different pathways, both encouraging
cell cycle progression and inhibiting
apoptosis, a form of
cell death, the researchers found.
Giving the mice antibiotics helped gemcitabine kill tumor
cells, increasing the number of tumor
cells going
through a type of
cell death called
apoptosis from about 15 percent to 60 percent or more.
So alpha - lac may induce
apoptosis by directly causing the destruction of DNA from within the
cell's nucleus, or it may instigate the suicide - generating caspace cascade
through the mitochondria.
At the IMCB, headed by Professor Chris Tan, we were able to increase our productivity
through closer collaborations and interactions with scientists studying
apoptosis and
cell regulation.
«Most chemotherapies kill cancer
cells through apoptosis, and the cancer
cells that escape
apoptosis are the root cause of chemotherapy resistance and tumor progression,» said Chi.
The experiments performed by postdoctoral researcher Dr Xu revealed that BET inhibitors principally act to kill cancer
cells through the process of
apoptosis, or programmed
cell death.
«In modern biology mitochondria are considered to be much more than the powerhouse of the
cell; they integrate multiple intracellular signals to regulate progression
through the
cell cycle and into
apoptosis.
«New approach for AIDS: Lock HIV in reservoir
cells, to die
through apoptosis.»
When L - HIPPO was added to virus - infected
cells via a carrier called α - CDE, the virus became confined within the
cell and the
cell would die
through natural
apoptosis.
The
cells then die naturally
through apoptosis (
cell death).
Once the bacterial
cell signaling protein cagA reaches the host cytosol, it is capable of altering subsequent generations of progenitor
cells, leading to the development of cancer
through changes in mitotic activity,
apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial adhesion with gastric epithelial
cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.
Effects of miR -145-5p
through NRAS on the
cell proliferation,
apoptosis, migration, and invasion in melanoma by inhibiting MAPK and PI3K / AKT pathways.
Citrus limonin and its glucoside inhibit colon adenocarcinoma
cell proliferation
through apoptosis.
The tumor suppressor p53 is critical in the protection of
cells against radiation - induced carcinogenesis, most likely
through its ability to trigger
apoptosis of radiation - damaged
cells (45).
Moreover; the PI3K / AKT pathway also can contribute to melanoma tumorigenesis
through mutations or loss in PTEN and dysregulation in expression of AKT, which positively regulates the G1 / S phase progression in
cell cycle, suppresses
apoptosis and promotes cellular survival.
Phosphatase and tensin homologue (PTEN)- induced putative kinase 1 reduces pancreatic β -
cells apoptosis in glucotoxicity
through activation of autophagy.
It was shown that VPA could induce the
apoptosis of activated T
cells and maintain immune homeostasis
through the caspase - 8 / caspase - 3 pathway (28).
Independent of MMP activity, TIMP - 1 can promote growth and inhibit
apoptosis through various pathways, including P13K and PKA [9] and, furthermore, TIMP - 1 is able to provide β
cell - specific pro-survival effects [5, 6, 10].
This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma
cell lines by modulating
cell cycle arrest and
apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma
cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B -
cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T -
cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid
cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS
through a PU.1 - dependent gene expression program.
We then examined whether VPA regulated immune homeostasis and ameliorated GVHD
through inducing
apoptosis of CD4 + T
cells in vivo.
Chen Y, Liu J, Yuan B, Cao C, Qin S, Cao X, Bian G, Wang Z and Jiang J. Methylated actinomycin D, a novel actinomycin D analog induces
apoptosis in HepG2
cells through fas - and mitochondria - mediated pathways.
Angiopoietin - Like 4 Confers Resistance to Hypoxia / Serum Deprivation - Induced
Apoptosis through PI3K / Akt and ERK1 / 2 Signaling Pathways in Mesenchymal Stem
Cells
Titles: 1) Angiopoietin - Like 4 Confers Resistance to Hypoxia / Serum Deprivation - Induced
Apoptosis through PI3K / Akt and ERK1 / 2 Signaling Pathways in Mesenchymal Stem
Cells
Manuscripts that increase our understanding of the processes
through which stem
cells and progenitors differentiate into committed progeny, the commitment
cell death programs such as
apoptosis and necrosis, aging, and the transition between proliferation and
cell cycle arrest are welcome.
15 - deoxy - Δ12, 14 - prostaglandin J2 (15d - PGJ2), a prostaglandin derivative, has shown its anti-tumor activity by inducing
apoptosis through reactive oxygen species (ROS)- mediated inactivation of v - akt, a murine thymoma viral oncogene homolog, (AKT) in cancer
cells.
Notably, genes thought to induce and promote
apoptosis through the intrinsic mitochondrial apoptotic pathway, such as KLF10 [32], were not altered in differentiated
cells or in treated versus untreated
cells.
Melanoma Differentiation Associated Gene - 7 / Interleukin - 24 Promotes Tumor
Cell - Specific
Apoptosis through Both Secretory and Nonsecretory Pathways
Inecalcitol, an analog of 1,25 D 3, displays enhanced antitumor activity
through the induction of
apoptosis in a squamous
cell carcinoma model system.
Moreover, LA prevented the prostatic hyperplasia induced by testosterone in rats, triggered
apoptosis in colon cancer
cells through oxidative stress and improved the sensitization of the EGFR inhibitor cetuximab in KRAS / BRAF mutated colorectal cancer
cells.
Ma H, Liu B, Feng D, Xie H, Li R, Yuchi Y, Wang H, Wang J. Pinus Massoniana Bark Extract Selectively Induces
Apoptosis in Human Hepatoma
Cells, Possibly
Through Caspase - dependent Pathways.
Liu J, Bai J, Jiang G, Li X, Wang J, Wu D, Owusu L, Zhang E, Li W. Anti-tumor Effect of Pinus Massoniana Bark Proanthocyanidins on Ovarian Cancer
Through Induction of
Cell Apoptosis and Inhibition of
Cell Migration.
Some studies show that in a laboratory setting, they cause cancer
cells to self - destruct
through a process called
apoptosis.
All
cells have the ability to go
through a process called
apoptosis, or programmed
cell death.
Cancer patients who increase eating raspberries create the potential to destroy malignant growths
through a process known as
Apoptosis, a systematic
cell death via a biochemical reaction.
The study team discovered that GSE targets colorectal cancer
through inducing oxidative stress that leads to the programmed
cell death known as
apoptosis.
Chidambara Murthy, K.N., et al., Citrus limonin and its glucoside inhibit colon adenocarcinoma
cell proliferation
through apoptosis.
Functional Nutriments
Through pet specialty retailers, the company offers proprietary canine nutraceuticals with ingredients such as curcumin and luteolin, which support
apoptosis, or natural
cell health.
We all rely on those policemen
cells to locate them, and destroy them
through a process called
apoptosis.