Sentences with phrase «cell applications which»

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These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Juno's setbacks contrast with the biologics license application planned this year by Novartis, and the rolling BLA in progress by Kite Pharma — which on Tuesday reported positive 6 - month trial data for its CAR T - cell lead candidate.

Initial results already show stable charge - discharge cycling for as long as 200 hours, which is long enough for use in some industrial or military applications, but not nearly adequate for batteries used in laptops or cell phones.

In another application, the sensor was used to study how cells respond to the introduction of extracellular hydrogen peroxide, which produces a wave of oxidation as it moves through the cellular structures.

«A future application of this material is the observation of individual cell membranes because our material is suited for observing nanoscale NMR on the volume scale of 17 cubic nanometers, which is comparable to the thickness of cell membranes (~ 5 nanometers),» Ishiwata said.

Quantum dots, which have use in diverse applications such as medical imaging, lighting, display technologies, solar cells, photocatalysts, renewable energy and optoelectronics, are typically expensive and complicated to manufacture.

To capitalize on the discovery, Kyoto University set up the $ 40 - million Center for iPS Cell Research and Application (CiRA), which Yamanaka directs.

Furthermore, because this technology is RNA - based, it does not integrate into the genome, which makes the cells eligible for clinical application.

In response to a query from Science, Kyoto University's Center for iPS Cell Research and Application, which Yamanaka directs, issued a statement that reads in part: «Our university filed the world's first patent application associated with iPS [cell] technology and is now trying to acquire patent rights in many countries, including the UCell Research and Application, which Yamanaka directs, issued a statement that reads in part: «Our university filed the world's first patent application associated with iPS [cell] technology and is now trying to acquire patent rights in many countries, includinApplication, which Yamanaka directs, issued a statement that reads in part: «Our university filed the world's first patent application associated with iPS [cell] technology and is now trying to acquire patent rights in many countries, includinapplication associated with iPS [cell] technology and is now trying to acquire patent rights in many countries, including the Ucell] technology and is now trying to acquire patent rights in many countries, including the U.S..

The discovery relies upon a «conjugated redox polymer» design with a naphthalene - bithiophene polymer, which has traditionally been used for applications including transistors and solar cells.

She is now developing new biomaterials which support cell regrowth, nano - encapsulation for targeted release of drugs and new drug candidates for skin and aging applications.

This biomolecule is used in optogenetic applications, which is deployed to control the activity of living cells with light.

This will open new application possibilities to utilize printable solar cells e.g. in IoT (Internet of Things) type applications, in which the devices can also harvest energy from the ambient light.

Researchers at The University of Texas MD Anderson Cancer Center have announced a new method for detecting DNA mutations in a single cancer cell versus current technology that analyzes millions of cells which they believe could have important applications for cancer diagnosis and treatment.

If you do hydrogen evolution, producing hydrogen from water, that's water electrolysis, which produces clean hydrogen for fuel cells and other applications.»

The new perovskite solar cells have achieved an efficiency of 20.1 per cent and can be manufactured at low temperatures, which reduces the cost and expands the number of possible applications.

The majority of modern fuel cells, specifically those used for automotive applications, are proton exchange membrane (PEM) fuel cells, which functions by exchanging protons across an acidic polymer membrane to produce electricity and heat.

Strontium cobaltites are just one example of a class of materials known as transition metal oxides, which is considered promising for a variety of applications including electrodes in fuel cells, membranes that allow oxygen to pass through for gas separation, and electronic devices such as memristors — a form of nonvolatile, ultrafast, and energy - efficient memory device.

«The kidney is a very solid organ, which makes it very difficult to bring enough number of cells upon transplantation,» explains Professor Kenji Osafune, whose lab at the Center for iPS Cell Research and Application (CiRA) at Kyoto University, Japan, is using iPSCs to investigate new treatments for kidney disease.

The batteries tend to be light compared with conventional lithium - ion cells, which should encourage their use in applications such as powering unmanned aircraft and underwater robots.

With the discovery, the material that the researchers call «metal oxide - laser induced graphene» (MO - LIG) becomes a new candidate to replace expensive metals like platinum in catalytic fuel - cell applications in which oxygen and hydrogen are converted to water and electricity.

«These composites, which have less than 1 percent metal, respond as «super catalysts» for fuel - cell applications.

The researchers describe the successful application of their strategy in mice in «Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion,» which will be published online August 15 ahead of issue in The Journal of Experimental Medicine.

«Dolly the Sheep told me that nuclear reprogramming is possible even in mammalian cells and encouraged me to start my own project, wrote Yamanaka, who splits his time between the University of California, San Francisco, and the Center for iPS Cell Research and Application (CiRA) at Kyoto University in Japan, which he directs.

To explore the potential for application, the group then attempted a similar experiment using human blood stem cells taken from umbilical cords, which they transfected with a vector encoding human Id3.

The device, which combines acoustic cell - sorting and microfluidic technologies, could be a boon to both scientific research and medical applications.

T cells, which circulate in the blood, are an obvious candidate for medical applications of the technology, as these cells not only stand at the center of many disease processes, but could be easily gathered from patients, edited with CRISPR / Cas9, then returned to the body to exert therapeutic effects.

Butler hopes to be able to create one type of interneuron at a time, which would make it easier to define the separate roles of each cell type and allow scientists to start the process of using these cells in clinical applications for people who are paralyzed.

These are important steps towards future applications in regenerative medicine, which would require the use of stem cells to create specialised cells, tissues or organs to maintain normal function.

Therefore, applications that require simultaneous modification of all alleles of a gene, or which require modifying multiple genes simultaneously in the same cell, are more appropriate for a CRISPR - based approach.

«Thermoelectric batteries, like ours, have been proposed before but those have been based on liquid - based cells, which are impractical for real - world applications.

BERKELEY, CA, and CORALVILLE, IA — February 23, 2016 — Caribou Biosciences, Inc., a developer of CRISPR technologies for precision cell engineering, and Integrated DNA Technologies, Inc. (IDT), a producer of custom synthetic oligonucleotide - based technologies for genomics applications, have entered into a non-exclusive license agreement under which Caribou has granted IDT worldwide rights to commercialize CRISPR - Cas9 reagents under Caribou's intellectual property.

In addition, Celvive has partnered with a US - based FDA - approved manufacturer to produce the StemCure ™ cell isolation and delivery system which has been tested to prepare for an IND application with the FDA for the second phase of clinical studies in the US.

We hope that these efforts will allow us to identify means by which the response of iNKT cells can be manipulated to effect desired immunologic outcomes in possible therapeutic applications.

Perhaps you have seen recent applications in by several groups, which show that, indeed it's possible to reprogram cells within the brain, even the adult brain in vivo.

However, Shinya Yamanaka's formula for iPSCs, for which he was awarded last year's Nobel Prize, uses a strict recipe that allows for limited variations in human cells, restricting their full potential for clinical application.

Yamanaka, 55, is now director of the Center for iPS Cell Research and Application (CiRA) at Kyoto University, which conducted the genetic analysis for the first iPS cells to be transplanted into a human.

«To create this sophisticated system of checks and balances, we also made sure that the kill switches themselves remained fully intact, which is an important prerequisite for future applications; we verified that they were still functional after about 140 cell divisions.»

He is specifically interested in capturing electrons more efficiently, which will help development of other useful microbial fuel cell applications.

For work on optical tweezers for biological applications which use focused laser light to trap and manipulate virus particles, living cells and other biological entities whilst allowing them to maintain viability.

We are also interested in therapeutic application of convertase inhibitors, which we test in cell - based assays (see recent publications).

This new information contributes to understanding protein stability and electron transfer between cells and minerals, which is important for applications in synthetic biology such as biofuel production.

It will focus on catalyst development for four applications: proton exchange membrane fuel cells to convert stored energy in non-fossil fuels into electricity; electrolysers for splitting water into oxygen and hydrogen — a potential clean fuel cell source; syngas, a mixture of CO and H2, which is generated from coal, gas and biomass, and widely used as a key intermediate in the chemical industry; and lithium - air batteries.

This has allowed investigation of the mechanical properties of cells, which, according to some research studies, could have applications in medicine, for example by enabling cancer cells to be distinguished from healthy ones.

STEMCELL scientists will also discuss other applications and cell types for which EasySep ™ can be used to accelerate scientific discovery.

We are the home of the UK Stem Cell Bank which provides a world - leading resource of ethically - sourced, quality - controlled human embryonic and other stem cell lines for research applicatiCell Bank which provides a world - leading resource of ethically - sourced, quality - controlled human embryonic and other stem cell lines for research applicaticell lines for research applications.

The researchers are currently exploring this and other questions to elucidate the process by which stem cells protect a heart after an myocardial infarction and help translate it for human application.

SOX2 is one of two key genes researchers use to generate induced pluripotent stem cells (iPSCs), which are capable of differentiating into all cell types for research and potential therapeutic applications.

«Having a very efficient and practical way of generating patient - specific stem cells, which unlike human embryonic stem cells, wouldn't be rejected by the patient's immune system after transplantation brings us a step closer to the clinical application of stem cell therapy,» says Belmonte, PhD., a professor in the Gene Expression Laboratory and director of the Center of Regenerative Medicine in Barcelona, Spain.

Therefore, this work provides strong support for the use of iPSC ‐ derived MSC as a more uniform with well ‐ defined phenotype and function as a sustainable source of cells which paves the way for a clinical application for IBD cellular therapy.