Sentences with phrase «cell autoimmunity»

β - Cell autoimmunity probably propagates continuing destruction of β - cells and prevents islet cell regeneration after injury (90).

Multiple environmental factors likely initiate β - cell autoimmunity, which, once begun, proceeds by common pathogenic pathways.

The association between canine diabetes and pancreatitis warrants particular attention, because β - cell autoimmunity, pancreatic inflammation, and regulation of gut immunity may be linked in disease pathogenesis.

Although genetic susceptibility appears to be a prerequisite in type 1 diabetics, multiple environmental factors likely initiate β - cell autoimmunity, which, once begun, proceeds by common pathogenic pathways (74).

Now the scientists have found increased frequencies of these cells in samples of children with recent onset of islet cell autoimmunity — an early stage of type 1 diabetes.

Not exact matches

Autoimmunity is commonly caused by bacterial infections or overgrowth in the small intestine, in which partially digested food compounds are incorporated into bacterial cell walls and then the immune system, reacting to the bacteria, forms antibodies that also recognize food compounds, some of which might cross-react with human counterparts.

«Perhaps the same process is going on with autoimmunity,» says Howard Hughes Medical Institute immunologist Philippa Marrack, who also studies B - cells and the TLR7 receptor.

For unknown reasons our immune system attacks healthy cells, tissues and organs in a process called autoimmunity, which can result in diseases such as multiple sclerosis, type 1 diabetes, lupus or rheumatoid arthritis.

It is these people who develop diabetes, either type 1 or type 2, while others with tougher beta cells will remain healthy even in if they suffer from autoimmunity or metabolic dysfunction of the liver.»

The point for PANS: In diseases of autoimmunity, where rogue immune cells are stuck in the brain, returning these lymphatic vessels to greater function may be a potent means of clearing up disease.

«The ability to control autoimmunity by autologous HSCT [hematopoietic stem cell transplantation] has been demonstrated in other treatment - refractory autoimmune conditions, including neurologic diseases.

«What's remarkable is that B cells are the ones making antibodies and autoantibodies, so they're really crucial in both protective immune responses and autoimmunity,» said Montserrat C. Anguera, assistant professor in the Department of Biomedical Sciences in Penn's School of Veterinary Medicine and the senior author on the study.

TLR7 is one of a family of receptors present on innate immune cells like macrophages that have been linked to chronic inflammation and autoimmunity.

They are designed to get around one of the ways that cancer protects itself from the immune system: tumors can activate the body's natural protective response from autoimmunity, called a checkpoint, and thereby thwart cytotoxic T cells.

«We have immune cells called T - cells that are really good at killing off cancer cells, but there is an inhibition system in place to prevent autoimmunity,» said the study's senior author Maureen Su, MD, UNC Lineberger member and associate professor in the UNC School of Medicine Division of Pediatric Endocrinology.

Islet autoimmunity, detected by antibodies that appear when the immune system attacks the islet cells in the pancreas that produce insulin, is a precursor to type 1 diabetes.

These loci are known to be involved in various processes including cell senescence, autoimmunity and cell signaling, and also with Alzheimer's disease.

Areas covered range from basic studies into the biology of innate and adaptive immunity (immune cell development and differentiation, immunogenomics, systems immunology, structural immunology, antigen presentation, immunometabolism, and mucosal immunology) to immune contributions to health and disease (host defense, inflammation, cancer immunology, autoimmunity, allergy, transplantation, and immunodeficiency).

But in patients with type 1 diabetes, beta - cell replacement therapy is likely doomed to failure because the new cells might fall victim to the same autoimmunity that destroyed the original cells.

Around 0.4 % of newborns will develop autoimmunity to pancreatic beta cells in childhood and receive a diagnosis of type 1 diabetes before adulthood.

«This helps us understand that process, and it opens up the window to targeting these cells by designing vaccines that prevent autoimmunity.»

His laboratory harnesses the tools of synthetic and chemical biology to engineer the immune cell therapies for cancer and autoimmunity of the future.

«Tolerating yourself: A novel pathway to regulate B cell activity and prevent autoimmunity.»

- In a study with potentially major implications for the future treatment of autoimmunity and related conditions, scientists from the Perelman School of Medicine at the University of Pennsylvania have found a way to remove the subset of antibody - making cells that cause an autoimmune disease, without harming the rest of the immune system.

The engineered T cells also performed successfully in a mouse model of PV, killing desmoglein - specific B cells and preventing blistering and other manifestations of autoimmunity in the animals.

B cells, which produce antibodies, can also cause autoimmunity.

Payne researches autoimmunity, and a few years ago, a postdoctoral researcher in her laboratory, Christoph T. Ellebrecht, MD, took an interest in CAR T cell technology as a potential weapon against B cell - related autoimmune diseases.

Also on the horizon for the Penn scientists are applications of CAAR T cell technology for other types of autoimmunity.

Aggressor cells, which have the potential to cause autoimmunity, are targeted by treatment, causing conversion of these cells to protector cells.

This study shows how exhausted T cells do not maintain a durable switch to an effector T cell profile, although in the clinic, checkpoint inhibitors are well tolerated and their side effects such as autoimmunity are usually manageable.

Autism, meanwhile, has been linked to brain inflammation, microglial cell activation, cytokine imbalances, and autoimmunity.

Other researchers at Joslin are conducting large scale genetic screening for novel therapeutic targets to control autoimmunity, which will complement the effort of BAIRT to extend autologous beta cell replacement to patients with type 1 diabetes.

Shimon Sakaguchi identifies regulatory T cells (CD4 + CD25 +) and their role in protecting against autoimmunity.

Enhanced expression of one of these molecules, CD1d, is coupled to selective induction of invariant natural - killer T cells (iNKT), a subset of T lymphocytes that are present at low levels in lymphocyte populations and whose absence enhances autoimmunity in animal models.

2B4 appears to be similar; it appears on exhausted T cells after chronic viral infection, and its absence can contribute to autoimmunity.

[ii] Importantly, these results illustrate the interphase between tumor immunity and autoimmunity, since several tumor antigenic proteins are co-expressed by normal and tumor cells.

Tissue - specific expression of B7x protects from CD4 T cell — mediated autoimmunity.

CD4 + regulatory T (Treg) cells expressing the forkhead box transcription factor Foxp3 have a vital function in the maintenance of immune homeostasis and the prevention of fatal multi-organ autoimmunity throughout life.

In the last decade, Foxp3 + Treg cells have raised the hope for novel cell - based therapies to achieve tolerance in clinical settings of unwanted immune responses such as autoimmunity and graft rejection.

My specialty is on microRNA as expressed by the thymic microenvironment for the generation of regulatory T cells (Tregs) and how these molecular interactions establish central tolerance to promote protection from autoimmunity.

Differential regulation of central nervous system autoimmunity by T (H) 1 and T (H) 17 cells.

Understanding how the autoimmunity initiates and is perpetuated is relevant to introducing therapies that will prevent beta cell destructive immunity.

Mesenchymal stem / stromal cells precondition lung monocytes / macrophages to produce tolerance against allo - and autoimmunity in the eye.

Editorial Boards PLoS ONE (Academic Editor), Frontiers in Mucosal Immunity, The Open Autoimmunity Journal, The Open Biomarkers Journal, Recent Patents in Biomarkers, The World Journal of Stem Cells, The World Journal of Experimental Medicine, The World Journal of Immunology.

And CD4 + T - cells in the blood vessels of vaccinated mice were rare, contrasting with experimental autoimmune encephalomyelitis (EAE) mice, which are a positive control model of T - cell - mediated CNS autoimmunity.

The range of subjects includes, but is not limited to, immune cell development and senescence, signal transduction, gene regulation, innate and adaptive immunity, autoimmunity, infectious disease, allergy and asthma, transplantation, and tumor immunology.

Now, a novel computational method shows that a viral protein found in EBV - infected human cells may activate genes associated with increased risk for autoimmunity.

Dr. Payne and colleagues have devised an exceptionally innovative approach to re-engineer chimeric antigen receptor (CAR) T cells for therapy of autoimmunity.

Made major contributions to the field of immunology through his studies on immune tolerance in animal models, with particular focus on transplantation tolerance and autoimmunity, in addition to pioneering the use of therapeutic monoclonal antibodies against T cells, resulting in the development of Campath - 1H, the first humanised monoclonal antibody to be used therapeutically.

Histone deacetylase 9 deficiency protects against effector T cell - mediated systemic autoimmunity.