Sentences with phrase «cell barriers function»

ECIS currently is used to monitor how cells react to drugs and to assess how cell walls or cell barriers function.

Not exact matches

Both of these cell layers act as a barrier to small molecules and ions that protects the organs and enables specialized functions, such as absorption in the intestine or urine secretion in the kidney.

This blood vessel normalization results in an increased barrier function on the one hand — thereby blocking cancer cell dissemination and metastasis - and in enhanced tumor perfusion on the other hand, which increases the response of the tumor to chemotherapy.

The researchers concluded that using collagen - based membranes in organ - on - a-chip devices enhance the growth, viability and barrier function of human colon cells and that the method likely could be extended to cells from other organs.

Asparagine, however, is not well transported to the brain via the blood - brain barrier,» said senior co-author of the study Dr. Jacques Michaud, who found that brain cells depend on the local synthesis of asparagine to function properly.

According to Dr. Bleich and his co-investigators, «Epithelial barrier function is predominantly dependent on tight junction proteins, which regulate transport into and between cells.

«It has been very difficult to study cell junctions, which maintain the skin's barrier function by keeping cells attached to each other,» says Sinha.

[The intracellular domain's function of] transcribing a gene into a protein that then performs some function within the cell generally takes about two hours, but we were seeing leakage within 30 minutes of blocking Notch1, further suggesting that whatever process controls the permeability of the barrier is operating via a completely different mechanism,» says Bill Polacheck, Ph.D., Postdoctoral Fellow at the Wyss Institute and co-first author of the paper.

Cortisone helps to enhance the barrier function of the endothelium, preventing vascular leakage and further infiltration of the alveolar space by immune cells.

«It turns out that calnexin is somehow involved in controlling the function of the blood - brain barrier,» said Marek Michalak, a distinguished professor of biochemistry at the U of A. «This structure usually acts like a wall and restricts the passage of cells and substances from the blood into the brain.

Key elements of the immune system, they also have the ability to turn into several cell types after having passed the endothelial barrier, in order to fulfil different functions depending on the tissue.

The researchers analyzed the exposed cells to determine the effects of fungal exposure on permeability properties and barrier function of the epithelium.

«The microfluidic cell cultures reproduced functions of the airway tissues such as mucus secretion and acted as a barrier to molecules,» said Katelyn Sellgren, Ph.D., a postdoctoral research scientist at RTI and first author of the paper.

Corresponding to the primary function of epithelial tissues, i. e. forming a barrier between compartments, epithelial cells form tight adhesions between each other, and display only lateral mobility, confined by the basement membrane.

Macrophage depletion alters the blood — nerve barrier without affecting Schwann cell function after neural injury.

Modulating ECM assembly to alter tumor vascular barrier function Weilan Ye, Genentech Lymphangiogenesis and lymphatic endothelial barrier as targets in regenerative medicine Giorgia Jurisic, Novartis Wnt / beta - catenin signaling as a therapeutic target for blood - brain barrier repair in neurological disorders Dritan Agalliu, Columbia University Somatic mutations in hematopoietic cells contribute to cardiovascular disease: New mechanisms, new targets Kenneth Walsh, Boston University

Hence, development of technologies capable of effectively overcoming these barriers for delivery of cell engineering materials, while preserving critical cell functions, is vital to success.

The SPG cell layer, which is adjacent to the neurons of the brain, forms septate junctions, which function as a barrier to separate the humoral space and the brain, analogously to the mammalian tight junctions formed between endothelial cells.

B. anthracis secretes lethal toxin, which contributes to barrier disruption via interference of epithelial, endothelial and immune cell function [5].

Using a series of genetically - matched euploid and aneuploid cell lines, we have demonstrated that aneuploidy can paradoxically function as a barrier to tumor growth.

The AAV9 containing a functioning NPC1 gene successfully crossed the blood - brain barrier, reaching cells in the brain and elsewhere.

One study puts it this way: «Glutamine has protective effects on intestinal mucosa by decreasing bacteremia and epithelial cell apoptosis, enhancing gut barrier function, and influencing gut immune response» [3].

(2) In a recent study examining gut barrier function, IBS patients had significantly more «gaps» between the cells of the intestine compared to healthy patients.

Necessary for healthy cell functioning, this is one of only a few nutrients that are capable of passing through the blood - brain barrier.

Diversity of tight junctions (TJs) between gastrointestinal epithelial cells and their function in maintaining the mucosal barrier.

LaFlore's ingredients allow the skin to breath and function at optimal levels, improving flow and helping your cells turn over on their own, resulting in collagen and elastin synthesis for skin renewal and improved natural barrier functions.

In the small intestine, gluten triggers the release of zonulin, a protein that regulates the tight junctions between epithelial cells and therefore intestinal, but also blood - brain barrier function.

In addition, curcumin significantly improves barrier function, reducing translocation of lipopolysaccharide (LPS), the outer cell wall of gram - negative bacteria, from the luminal surface of the intestine into circulation (Ghosh et al., 2014).

More specifically, glutamine is believed to increase cell differentiation and improve gut barrier function.

Our skin cells and barrier function (the protective layer that keeps the good stuff in and the bad stuff out) start to break down earlier than we'd care to admit.

They compete with candida in the intestine, they suppress the growth of potentially harmful bacteria, they produce substances that can lower cholesterol, they enhance the protective barrier of the digestive tract, they help produce vitamin K, they improve immune function, they lower blood cholesterol in some people, they lower blood pressure in some people, they aid in the digestion of lactose, they prevent cavities, they decrease the passage of bacteria or antigens from the intestines to the blood stream, they fight pre-carcinogenic or mutagenic compounds, they lower the pH of intestinal contents, they utilize oxalate (oxalate contributes to kidney stones), they detoxify ingested carcinogens, they produce compounds that inhibit the growth of tumor cells, and more!

Since glucose is needed for the mucosal barrier, for cell junctions and gut barrier integrity, and for immune function, zero - carbing makes it much easier for pathogens to reach the brain.

«Alternatively, hot liquids may impair the barrier function of the cells lining the esophagus, leaving the tissue open to greater damage from other carcinogens.»

Niacinamide has been shown to improve the skin's barrier functions by increasing cell turnover and proliferation, as well as lipid production, all of which make the skin better able to retain moisture, heal itself, and combat irritants.

«Moisturizer impedes this process, and while exfoliation is often thought of as really harsh, it will actually strengthen your skin's barrier function by stripping away weakened cells on the skin's surface and letting stronger, fresher cells underneath come forward.»

The microbial host defense can be weakened by secondary or acquired diseases (injury, endocrinopathy, cancer or co-infection) or primary inherited disorders that affect the barriers that keep infection out or functions of white blood cells.