Sentences with phrase «cell behavior»

The program also allowed the researchers to address aspects of cell behavior that emerge from vast numbers of interacting factors.

Even small changes in gene activity can change cell behavior dramatically, so this fine - tuning may open up new avenues for studying gene function.

As new examples of beneficial noise come to light, scientists are working to better understand the implications for cell behavior, evolution and human health.

His research group focuses on big data network biology, exploring biological systems by developing and deploying algorithms aimed to predict cell behavior, in particular looking at cellular signal processing and decision making.

In collaboration with experimental groups we make use of these possibilities and apply methods from statistical physics to unveil the mechanisms regulation cell behavior on the molecular level.

With the aid of the automated system we were able to observe cell behavior that would be impossible to discover by conventional microscopic observation.

Conventional time - lapse recordings have provided new data of living cell behavior and growth.

«Martin's vision for genetic analysis of pluripotency, afforded by our extensive mouse resources, could lead to major advances in our understanding and manipulation of stem cell behavior in health and disease.»

Martin's vision for genetic analysis of pluripotency... could lead to major advances in our understanding and manipulation of stem cell behavior in health and disease.

«These origami can be customized for use in everything from studying cell behavior to creating templates for the nanofabrication of electronic components,» says Dr. Thom LaBean, an associate professor of materials science and engineering at NC State and senior author of a paper describing the work.

Since it is still beyond the reach of even the most sophisticated in vitro methodology to simulate the complex interplay of physical, cellular, biochemical, and other factors that influence cell behavior in microvessels and interstitial tissues, we make use of intravital microscopy.

The glands lining the inner wall of the colon are the sites for most abnormal cell behavior such as uncontrolled cell growth, which results in polyps (non-cancerous growths) and later on in adenocarcinomas or tumors.

Biological Function of Ribosomal Protein L10 on Cell Behavior in Human Epithelial Ovarian Cancer Jimin Shi, Lingyun Zhang, Daibing Zhou, Jinguo Zhang, Qunbo Lin, Wencai Guan, Jihong Zhang, Weimin Ren, Guoxiong Xu J. Cancer 2018; 9 (4): 745 - 756.

The center will develop new single - cell approaches that overcome limitations inherent in traditional techniques — which analyze bulk populations of cells, thereby obscuring individual cell behavior.

In the adult central nervous system, the vasculature of the neurogenic niche regulates neural stem cell behavior by providing circulating and secreted factors.

Supported by National Institutes of Health grants, researchers at Oak Ridge National Laboratory (ORNL), the University of Tennessee (UT), and the UT — ORNL Joint Institute for Computational Sciences (JICS) discovered a molecular «switch» in a receptor that controls cell behavior using detailed molecular dynamics simulations on a computer called Anton built by D. E. Shaw Research in New York City.

Marcus stresses that SaGA can be applied to additional cell types or environments, or other types of cancer cell behavior such as drug resistance.

Normally, MIR506 plays an important role in regulating cell behavior; adequate levels help the cells function normally, while decreased levels trigger cell growth and expansion occurring in tumors.

For another, although the unusual T cell behavior was entirely absent in kids who didn't get autoantibodies later on, it was recorded in only about half who did.

To examine a cell at the molecular level, they must either kill it by impregnating it with resins or taint it with sensitive dyes, which can alter cell behavior even as they beautifully illuminate delicate structures.

This insight into cell behavior could help researchers better understand cell jamming and unjamming, which could lead to potential treatments for conditions such as developmental abnormalities, asthma, and cancer.

Capturing such information can reveal clues about cell behavior, but creating nanomaterials on which cells can survive for long periods of time yet don't interfere with the cellular processes being measured is a challenge, she explains.

Also look at the institution's broader scientific environment, because «you can benefit from help even from people that are not with the label «biomaterials,»» says Dupont - Gillain, who, as a bioengineer and physical chemist, collaborates with colleagues in surface science and cell biologists to develop biomimetic surfaces that can trigger desired cell behaviors.

The «domestication syndrome» in mammals: A unified explanation based on neural crest cell behavior and genetics.

For the subset of more recent patients, the researchers assessed tumor cell behavior — in particular, cancer cells» ability to cross the endothelium (inner layer) of blood vessels.

«This is the first study to show the actual cell behaviors caused by mutations in genes causally linked to polycystic kidney disease, an important new step in the path towards treatment,» said Dr. Robert L. Bacallao, associate professor of medicine at the IU School of Medicine in Indianapolis.

The research suggests that reducing production of the protein, called myoferlin, affects cancer cells in two primary ways: by changing the activation of many genes involved in metastasis in favor of normal cell behavior, and by altering mechanical properties of cancer cells — including their shape and ability to invade — so they are more likely to remain nested together rather than breaking away to travel to other tissues.

The team's final experiments demonstrated that these unbound integrin tails, indeed, get up to no good: they participate in the activation of two key biochemical pathways (PI3K and Rac1) that are necessary and sufficient to induce malignant cell behaviors in the in vitro epithelial tissue.

Photo - responsive hydrogels are of particular interest to material scientists, because light is regarded as an ideal tool to control molecules or cell behavior with high spatiotemporal precision and little invasiveness.

Our studies help in the design of biomaterials to promote bio-specific cell behavior (funded by the German Research Council SFB - TRR 67).

The paper appeared amid a growing recognition of the importance of mechanics, and not just genetics, in directing cell behavior, Fredberg said.

Specific technological advances: We have developed novel optical imaging and computational strategies using fluorescent and luminescent proteins to visualize cell behavior intravitally along the metastatic cascade.

Other researchers have tried changing cell behavior by creating protein switches from scratch, but Lim's approach — mixing and matching naturally existing proteins — may be more versatile and practical: «It can be useful as a biotechnology device or for repairing cells in humans.

Nanofiber orientation and surface functionalization modulate human mesenchymal stem cell behavior in vitro.

These nanoscale constructions can be customized for applications ranging from studying cell behavior to fabricating nanoelectronics.

We thought that the ability to spatially tune the stiffness of CMA would be a valuable research tool to probe how matrix stiffness influences cell behavior on 2D scaffolds and within a 3D environment,» said Shreiber.

Likely, your immune system aims to remove the cause of abnormal cell behavior, replace these abnormal cells with normal ones and heal your joints.

«We're seeing that some of these factors have a major impact on cell behavior that is not possible to observe in conventional 2D cell cultures.»

The center also develops new approaches that overcome inherent limitations in traditional techniques, which analyze bulk populations of cells, thereby obscuring individual cell behavior.

«It is clear that the fundamental principles that control cell behavior in simple animals are conserved and control the behavior of our cells as well,» she said.

Joe W. Ramos, PhD, deputy director of the UH Cancer Center and collaborators focused on investigating how these oncogenes and related signals lead to dysregulation of normal processes within the cell and activate highly mobile and invasive cancer cell behavior.

The biomedical engineers also showed that the exosomes contain miRNAs — tiny pieces of RNA that regulate cell behavior and are known to play a role in neuronal differentiation.

A protein called CTLA - 4 emerged as a key regulator of T cell behavior — one that signals to T cells the need to retreat from an attack.

A strategic focus is to continue to develop computational tools (such as KinomeXplorer, NetworKIN, and NetPhorest) and to deploy these on genome - scale quantitative data obtained by, for example, mass spectrometry, genomic, and phenotypic screens to understand the principles of how spatio and temporal assembly of mammalian signaling networks transmit and process information at a systems level in order to alter cell behavior.

High - throughput data acquisition streamlines complex experiments, while simple protocols for multiplexed analysis provide deeper insight into cell behavior.

Because DNA is encoded with the instructions for cell behavior, damaged DNA can alter cell processes including those that regulate growth and division.

«Mechanical properties are now accepted as an important regulator of cell behavior.

Tissue engineering provides a more practical means for researchers to study cell behavior, such as cancer cell resistance to therapy, and test new drugs or combinations of drugs to treat many diseases.

Similar to the naturally occurring effects of TET2 mutations in mice or humans, using molecular biology techniques to turn off TET2 in mice caused abnormal stem cell behavior.

«The more we know about the molecules that govern stem cell behavior, the closer we will get to controlling these cells.»