A pioneer of modern
cell biology used cell fractionation and electron microscopy to describe subcellular structures.
Not exact matches
He earned degrees in
cell biology and tissue engineering and eventually got a job in a lab run by Vladimir Mironov, who was investigating the
use of bioprinting — 3 - D printing
using living
cells — to generate replacement organs.
Lie4Him, Schweitzer, one of the first scientists to
use the tools of modern
cell biology to study dinosaurs, has upended the conventional wisdom by showing that some rock - hard fossils tens of millions of years old may have remnants of soft tissues hidden away in their interiors.
In my
cell biology course, we investigate the
biology and chemistry of a
cell surface receptor that helps induce good feelings in us when it binds to a chemical compound found in incense; this may help explain why so many different cultures and religions have independently evolved the
use of incense in their ceremonies and rituals.
As we read this history, the furor over stem
cells was fueled by numerous factors: the near - universal human desire for magic; patients» desperation in the face of illness and their hope for cures; the belief that
biology can now do anything; the reluctance of scientists to accept any limits (particularly moral limits) on their research; the impact of big money from biotech stocks, patents, and federal funding; the willingness of America's elite class to
use every means possible to discredit religion in general; and the need to protect the unlimited abortion license by accepting no protections of unborn human life.
Dennis has a PhD in genetics / developmental
biology from the University of British Columbia and a special interest in studying pattern formation and
cell -
cell communication during tissue development
using fruit flies as a model organism.
Without going into a complicated
biology lesson (which I probably would not be prepared to teach), let's simply think of what our digestive system does for us: it breaks food down into smaller pieces so that our body can
use this nourishment to build new
cells and give us energy.
The seventh - graders
used Gatorade, hot water and saliva to learn how scientists can break apart
cells to reveal DNA during the hands - on lesson from Dr. Roy Mason,
biology instructor and department
Dr Stephen Minger, director of the stem
cell biology laboratory at King's College, London, said religious leaders
use using «intentionally inflammatory» language.
Improved understanding of the
biology of cancer
cells has led to the development of biological agents that mimic some of the natural signals that the body
uses to regulate growth.
The fields within
biology are further divided based on the scale at which organisms are studied and the methods
used to study them: biochemistry examines the fundamental chemistry of life; molecular
biology studies the complex interactions of systems of biological molecules; cellular
biology examines the basic building block of all life, the
cell; physiology examines the physical and chemical functions of the tissues and organ systems of an organism; and ecology examines how various organisms interrelate.
«We
use molecular
biology and
cell biology techniques available today.»
What we are trying to do is introduce to
biology techniques normally
used in chemistry or physics,
using inherent chemical or structural properties of the human stem
cells.
Some of the researchers at the centre will study the differentiation of stem
cells into other
cell types, one group by
using human embryonic stem
cell biology and another by studying early embryo development.
Synthetic
biology enables researchers to tackle a huge and diverse range of applied problems: building a
cell with the smallest possible genome; synthesizing proteins with extra amino acids — more than the 20 found in nature;
using bacteria to produce medicines previously too complex to synthesize; even decomposing living organisms into standard, off - the - shelf «biobricks» that can be assembled on demand.
His lab began by working with Matt Bennett, assistant professor of biochemistry and
cell biology at Rice, to make
use of two tailored forms of E. coli bacteria created by Rice graduate student Chen Ye.
Visual props can help: Amy Rice Doetsch, who's on the
biology faculty at the College of Southern Idaho (CSI) in Twin Falls,
uses superballs to represent protons and tennis balls to represent electrons when describing electron transport in
cells.
Similar to the naturally occurring effects of TET2 mutations in mice or humans,
using molecular
biology techniques to turn off TET2 in mice caused abnormal stem
cell behavior.
Earlier, for his Ph.D., he
used his physics training to study biological interactions at the molecular resolution — but for his postdoc he changed approaches dramatically, turning to
cell biology and applying his skills to the development of high - resolution functional imaging of DNA transcription in living
cells.
«The mixtures of
cells under debate are called chimeras,» and animal chimeras are
used «in a range of developmental
biology and stem
cell experiments.
They also point out that the ability to
use EroS to spur mating opens up a whole new level of experimental control in probing the
cell biology of choanoflagellates.
«Our work could lead not only to a better understanding of the
biology of the optic nerve, but also to a
cell - based human model that could be
used to discover drugs that stop or treat blinding conditions,» says study leader Donald Zack, M.D., Ph.D., the Guerrieri Family Professor of Ophthalmology at the Johns Hopkins University School of Medicine.
Decades of work in developmental
biology have provided a start: Biologists have
used mutant frogs, flies, mice, chicks, and fish to identify some of the main genes that control a developing
cell's decision to become a bone
cell or a muscle
cell.
Like Medieval alchemists who searched for an elixir that could turn base metals into gold,
biology's modern alchemists have learned how to
use oocytes to turn normal skin
cells into valuable stem
cells, and even whole animals.
Our new device, which enables the precise manipulation and patterning of protein crystals
using surface acoustic waves, is a transformative technology for structural biologists,» said Jarrod French, an assistant professor of biochemistry and
cell biology at Stony Brook University.
In their new study, they adapted DNA - PAINT technology to microscopes that are widespread among
cell biology laboratories, called confocal microscopes, and that are
used by researchers to image whole
cells and thicker tissues at lower resolution.
Visibly fluorescent proteins (FPs) from jellyfish and corals have revolutionized many areas of molecular and
cell biology, but the
use of FPs in intact animals, such as mice, has been handicapped by poor penetration of excitation light.
This method is a new tool for
cell biologists and neuroscientists to
use to address questions ranging from fundamental mechanisms in
cell biology, to the underlying causes of mental illness, to the discovery of novel therapeutics.
His laboratory
uses a multidisciplinary approach encompassing systems
biology, molecular pharmacology, biochemistry / proteomics,
cell and structural
biology, and computation / bioinformatics.
Dr. Yaffe's research focuses on the
biology of the complex signaling pathways that
cells use to respond to DNA damage and inflammation, particularly the role of protein kinases and modular binding domains in tumor development and anti-cancer therapeutics.
Wei - Chuan Shih, associate professor of electrical and computer engineering, said fluorescence microscopy is «a workhorse,»
used in
biology, medical diagnostics and other fields to reveal information about
cells and tissue that can't otherwise be detected.
His current research
uses a variety of molecular, biochemical, and genetic approaches to study the basic
biology of mesenchymal stem
cells (MSCs).
«It is imperative to better understand the
biology of hMSCs, to best expand them and
use them in future therapeutic applications,» noted Dr. Jan Nolta, Editor in Chief of STEM
CELLS.
As well as the potential to produce pigment - correct skin grafts, the team's 3D bioprinting method could also be
used to develop skin constructs for toxicology testing and fundamental
cell biology research.
Jeff Smith, a first - year postdoc at OISB who studies
cell signaling
using proteomics, notes that with no specific categories for systems
biology on research - grant applications, he has no choice but to place himself in direct competition with biochemists and biologists in other fields.
Whatever their origin, the genetic changes raise questions over the widespread
use of HeLa
cells as models for human
cell biology, Steinmetz says.
We dissect the ovaries and embryos of spiders, crickets and milkweed bugs,
using molecular
biology and microscopy tools to map the genetic mechanisms that guide the emergence of germ
cells.
An international team of researchers from Denmark and Russia
used a series of biochemical and structural
biology techniques to investigate how the Qβ bacteriophage, which infects the common coli bacteria, utilises several of its host
cell's proteins while replicating its genetic material.
«The worm was initially
used as a model to study embryology and neurobiology, and starting in the late 1990s research expanded into stem
cell biology, tissue homeostasis, and regeneration, topics that are still very actively studied today,» he says.
The Salk and TSRI scientists
used a range of neuro - genetic, gene therapy, biochemical and structural
biology research techniques to discover that the mutant GlyRS enzyme blocked molecular signals important for maintaining the health of motor neurons, the
cells that carry messages from the brain to the muscles of the extremities.
«We make a science - based risk assessment [of a product], and if it's safe we
use it and if it's unsafe, we don't,» Stefan Jansson, a professor of plant
cell and molecular
biology at Umeå University's Plant Science Centre in Sweden, told ScienceInsider when ENVI approved its draft last month.
The team from the Massachusetts General Hospital plans to
use the microfluidic devices in synergy with some more sophisticated molecular
biology tools and identify the control factors of
cell migration speed.
This name can cause problems; in
biology the word «respiration» can mean cellular respiration or metabolism (ATP generation inside
cells), however sometimes (such as here) it can also refer to breathing (which is how the word is most often
used by non-biologists).
«People
used to think that this region of the medulla was only involved in the paralysis of skeletal muscles during REM sleep,» said lead author Yang Dan, a UC Berkeley professor of molecular and
cell biology and a Howard Hughes Medical Institute Investigator.
In the future, epigenetic editing could also be
used to design novel therapies by initiating permanent changes to
cell biology.
Scientists see the term in a more positive light,
using animal chimeras in a range of developmental
biology and stem
cell experiments.
«Nearly every animal has these small RNAs, and they
use them as a guide to look for target sequences and silence them,» said Heng - Chi Lee, PhD, assistant professor of molecular genetics and
cell biology at UChicago and senior author of the new study.
The research,
using cells from the Breast Cancer Now Tissue Bank and due to be published in Nature Communications, also shows that the epigenetic changes are inherited as long as the
cell divides, and that the team's manipulations permanently and negatively affected the
biology of a normal breast
cell from a healthy individual.
Scientists hope to
use stem
cells, which can develop into nearly any type of tissue in the body, to treat a variety of diseases as well as to study basic
biology (ScienceNOW, 30 November).
Instead of permanently deleting the Plk4 gene from the
cells, they
used a trick from plant
biology to toggle its presence in the
cells — one that had never before been applied to an animal
cell's proteins.