Not exact matches
In clinical trials the treatment — which involves extracting individual patients» immune T -
cells, modifying them to seek out tell - tale biological markers associated with blood cancers like aggressive lymphoma, and then pumping those modified killer
cells back into the
body — has
shown major promise, in some cases eliminating all signs of the cancer in patients six months after treatment.
This argument, however, falls, because we have
shown that although a
body, say, a plant, can accomplish what the individual
cells in it can not do, e.g., flower and bear fruit, still, the plant needs the ground as its «other.»
Thus, for example, they can
show that what a single
cell can not do by itself, the
body of which it is part can do.
Studies have
shown that their wide array of antioxidants actually inhibit the growth of cancer
cells, as well as protecting the
body from cardiovascular disease — orange vegetables have been
shown to provide the most protection against this disease.
Several studies
show that it can improve insulin sensitivity, as in how well the
body's
cells respond to insulin (24).
Previously, Derek Danahy of the University of Iowa and colleagues
showed that sepsis disrupts the immune system by reducing the amount and function of memory T
cells that circulate throughout the
body, recognizing and attacking specific bacteria, viruses, or cancer
cells.
Previous work in Weinberg's lab had
shown that after a tumor forms in one part of the
body, some of the cancer
cells undergo EMT, Mani explains.
Furthermore, it has been
shown that the
body's natural process of healing the wound created by surgery can actually spur these residual cancer
cells to metastasize to distant parts of the
body and form new growths.
The latest findings
show that genetic defects in the
body's ability to manufacture carnitine might be associated with an increased risk of autism because carnitine deficiency interferes with the normal processes by which neural stem
cells promote and organize embryonic and fetal brain development.
Furthermore, brain imaging data for these very elderly animals
shows a slight loss of grey matter (neuronal
cell bodies), an effect that the researchers have not yet explained, as well as significantly slowed atrophy of white matter (the neuronal fibers connecting different areas of the brain).
The nuclei of the T and dendritic
cell are colored green, the
cell body of the dendritic
cell is
shown in grey.
Previous work has
shown that retinoic acid, a chemical that results from the
body's natural breakdown of vitamin A, should act against these CK5 +
cells, but clinical trials of retinoids against breast cancer have been largely unsuccessful.
They also
showed that the
cells have most of the surface «markers» considered as identifiers of embryonic stem
cells and form «embryoid
bodies» — characteristic clumps of
cells formed by ESCs.
A 2009 study by the same researchers
showed that NF - kB helps normal
cells in DNA repair, which may prevent them from harming the
body.
«What our findings
show is that the problems with iPS
cells don't just involve one or two or a few abnormal iPS
cells escaping into the
body and forming tumors, but that the whole population of
cells is screwed up,» Lanza says.
A small
body of research that includes animal and
cell - culture studies, however,
shows that some of them can bind to hormone receptors.
The team
showed that exosomes could serve as an efficient carrier of RNAi, given that these nano - sized vesicles easily travel across the
body and enter
cells, including cancer
cells.
Adult stem
cells, reprogrammed or not, however, have not been
shown to have the same level of flexibility in becoming any
cell in the
body.
MicroRNAs in other
cells of the
body were unaltered in the specially bred mice but still there was a shortage of microRNA in their feces — suggesting a link between that which would normally be in the gut with the microRNA that
shows up in the feces.
When the scientists inserted human colorectal cancer
cells into zebrafish embryos and allowed them to grow for 4 days, the resulting tumors
showed three hallmarks of human solid tumors: rapid
cell division, formation of blood vessels to supply nutrients, and the ability to spread to other locations in the
body.
After more than six years of research, the research team led by María Soengas, head of CNIO's Melanoma Group,
showed that RAB7 acts as an orchestra director, determining the fate of melanoma
cells: at high concentrations of RAB7, cellular autodigestion is very active, and this allows tumor
cells to obtain energy, prevent the accumulation of toxic components and thus divide and proliferate; when RAB7 is reduced,
cells use endosomes to recycle metastatic proteins, favouring their dispersal throughout the
body.
About ten years ago, research results
showed that things are not quite as simple as that: «Under most conditions, H2O2 is not an undesired side product but rather an essential chemical messenger that plays an important role in regulating the way in which
body cells respond to signals from outside such as hormones and growth factors,» says Dr. Tobias Dick of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ).
Tubulin is labeled gold, highlighting the
cell body and flagellum, while the protein actin is labeled blue,
showing off the organism's distinctive collar.
In a study presented in the featured clinical investigation article of the November issue of The Journal of Nuclear Medicine, they used 18F - fluorodeoxyglucose (FDG) PET / CT imaging to
show that the amount of
cell - free tumor DNA circulating in the bloodstream correlates with tumor metabolism (linked to cancer aggressiveness), not tumor burden (amount of cancer in the
body).
Photo of a living Brainbow zebrafish, taken by Zachary Tobias (a research technician in Weissman - Unni's lab),
showing a brightly labeled neuron with its
cell body (white) at bottom.
In our platform,
cells looked and acted like those that you would find in the
body,
showing more sensitive responses to drugs than traditional static culturing.»
Associate Professor Palmer said that this next - generation test
showed that HIV hides in the
body's immune memory T -
cells, which is how it avoids detection from the immune system.
It has previously been
shown that rougher surfaces (also known as textured surfaces) reduce the amount of scar tissue formed around breast implants, but the Manchester scientists felt that they could improve this by creating a pattern which mimicked
body's own surface, such as the basal layer of the skin, providing a better environment for the
cells to grow on.
These findings are the first to
show that blood - forming stem
cells can be modified with a CAR therapy that can safely engraft in the bone marrow, mature and become functional immune
cells throughout the
body.
But the same brain
cells showed little or no response to other objects, such as images of vegetables, radios or nonfacial
body parts.
The left one
shows nerve
cell bodies and their projecting dendrites (both green), as well as supporting astrocytes (red).
This new study now
shows that BCL - 2 «teams up» with MCL - 1 and both these proteins crucially determine NK
cell survival in our
body, and the majority of NK
cells died following a reduction in the levels of BCL - 2.
The background image
shows a picture of the nematode C. elegans with clumps of the Huntington's aggregates (bright green because they're tagged with green fluorescent protein) in the
body wall muscle
cells.
The research, published in the journal Scientific Reports,
shows for the first time that the way in which fat is made within the
body is not «pre-programmed» during the early years of development as previously thought but even in adulthood
cells can be influenced by our environment to change the type of fat that is formed.
Most significantly, microscopy
showed that nuclei of ASF1 - depleted
cells contained aggregates of telomeric DNA, known as PML
bodies.
Now a team of scientists has
shown that even
cells in the skeleton — which we commonly think of as mere scaffolding — exude a hormone that helps the
body store fat and regulate sugar levels in the blood.
The
cell culture experiments
showed that MAbs prevented the uptake of misfolded α - syn fibrils by neurons and sharply reduced the recruitment of natural α - syn into new Lewy
body aggregates.
«This study adds to an important
body of work that has
shown the ubiquity of a circadian clock across species, including humans, and its role in metabolic regulation in
cells, organs, and organisms,» said Dr. Michael Sesma, Program Director in the Division of Genetics and Developmental Biology at the of the National Institutes of Health's National Institute of General Medical Sciences, which partially funded the research.
In a 2011 study, they
showed that CBD helps treat MS - like symptoms in mice by preventing immune
cells in their
bodies from transforming and attacking the insulating covers of nerve
cells in the spinal cord.
In a new study published in Science Advances, a group of University of Wisconsin - Madison researchers
show that individual
cells in the human
body have an armament designed to prevent HCMV from achieving and maintaining this latency, to shine a spotlight on the virus so the immune system knows to fight.
The latest research from the UCSB team
shows that specialized
cells in the squid skin called iridocytes contain deep pleats or invaginations of the
cell membrane extending deep into the
body of the
cell.
Scientists have
shown that fuel
cells implanted in rats can successfully generate electricity from sugar in the rodent's
bodies.
In recent years, research has
shown that what people commonly think of as «their»
bodies contain roughly 10 microbial
cells for each genetically human one.
Nagoya University - led study
shows for the first time germ
cells have an inherent property to feminize the
body in teleost fish, medaka.
«Our study
shows a whole new route, or bypass mechanism, for triggering the
body's adaptive immune response to TB infection, a means by which infected dendritic
cells cooperate with uninfected dendritic
cells to activate T
cells and respond to the infection,» says infectious disease specialist and study senior investigator Joel Ernst, MD, a professor at NYU Langone Medical Center.
Previous studies have
shown that white blood
cell telomere length can be predictive of biological aging and is linked with telomere length in other
cells in the
body.
«Civil war inside our
cells: Scientists
show how our
bodies fight off «jumping genes».»
The team
showed that IL - 33 can further enhance the response of memory T
cells, the long - lived
cells that can patrol and protect the
body from infections and cancers, when given with a DNA vaccine compared to a vaccine without IL - 33.
Dr Bernardo Tavora, lead author on the paper from the Barts Cancer Institute, said: «This work
shows that sensitivity to cancer treatment is related to our own
body mistakenly trying to shield the cancer from
cell - killing effects caused by radiotherapy and chemotherapy.
The federally funded study, published in the Journal of Leukocyte Biology,
showed how a stress receptor, known as corticotropin - releasing factor, or CRF1, can send signals to certain immune
cells, called mast
cells, and control how they defend the
body.