Filed Under: Clinical Trials, Veterinary Advances / Clnical Trials Tagged With: cats with cancer, clinical trial for cats with cancer, lessons from a paralyzed dog, National Pet Cancer Awareness Month, SCC oral cancer trial for cats, squamous
cell cancer trial for cats
Not exact matches
Kite Pharma, one of the companies chasing a new generation of
cancer drugs called chimeric antigen receptor T -
cell (CAR - T) therapies, announced a patient death in a clinical
trial of its experimental KTE - C19.
Researchers from the Sichuan University in Chengdu inserted the re-engineered
cells into a lung
cancer patient participating in a clinical
trial at the West China Hospital on October 28th, according to Nature.
In clinical
trials the treatment — which involves extracting individual patients» immune T -
cells, modifying them to seek out tell - tale biological markers associated with blood
cancers like aggressive lymphoma, and then pumping those modified killer
cells back into the body — has shown major promise, in some cases eliminating all signs of the
cancer in patients six months after treatment.
The PD - 1 checkpoint inhibitor Keytruda hit its goals in a new
trial in previously untreated non-small
cell lung
cancer patients, beating chemo at staving off
cancer progression and extending patients» lives.
Related Content Juno Halts Development of CAR T -
Cell Cancer Immunotherapy Candidate JCAR015 Two More Deaths Reported in Juno Car - T
Trial
Cambridge, MA — March 30, 2017 — Aura Biosciences, a biotechnology company developing a new class of therapies to target and selectively destroy
cancer cells using viral nanoparticle conjugates, announced today that it has enrolled and dosed the first patient in its Phase 1b clinical
trial of light - activated AU - 011, an investigational, first - in - class targeted therapy in development for the treatment of ocular melanoma, a rare and life - threatening disease.
In a mid-stage
trial, 16 of 37 lung
cancer patients given a placebo ahead of standard chemo wound up hospitalized with severely low white blood
cell counts.
Preclinical
trials indicate potential for noscapine as a
cancer drug with less toxicity to healthy
cells than currently available chemotherapies.
«This phase III
trial will be noteworthy for being the first prostate
cancer trial to assess a biomarker, namely AR - V7 in circulating tumour
cells, as a predictor of response at the same time as testing the efficacy of the drug,» Prof Taplin will conclude.
Based on results of the current study described in a report online June 18 in the journal
Cancer Cell, Johns Hopkins researchers say they are planning a phase I clinical trial to test the paclitaxel - fostamatinib combination therapy in patients with recurrent advanced ovarian c
Cancer Cell, Johns Hopkins researchers say they are planning a phase I clinical
trial to test the paclitaxel - fostamatinib combination therapy in patients with recurrent advanced ovarian
cancercancer.
«Current therapies in clinical
trials are focused on targeting genetic changes in tumors and helping to boost one's immune system to fight the
cancer cells.
A late breaking subanalysis of the phase III CONVERT
trial presented at the European Lung
Cancer Conference (ELCC) shows that white blood cell boosting drugs are safe during concurrent chemo - radiotherapy of small cell lung cancer (
Cancer Conference (ELCC) shows that white blood
cell boosting drugs are safe during concurrent chemo - radiotherapy of small
cell lung
cancer (
cancer (SCLC).
«Fibroblast growth factor receptor inhibitors are new therapies being developed in clinical
trials for patients whose
cancer cells have genetic alterations in this family of genes,» says Roychowdhury, a member of the OSUCCC — James Translational Therapeutics Program.
In the context of the collaboration between the Gates Center for Stem
Cell Biology and the CU
Cancer Center this was the second clinical
trial we offered to our patients with the specific intent to eliminate the CSCs in their tumors.»
In a head - to - head clinical
trial comparing standard chemotherapy with the immunotherapy drug nivolumab, researchers found that people with squamous - non-small
cell lung
cancer who received nivolumab lived, on average, 3.2 months longer than those receiving chemotherapy.
Now a University of Colorado
Cancer Center study published online ahead of print in the journal Oncogene offers compelling evidence explaining this failure and offering a possible strategy for the use of retinoic acid or other retinoids against some breast cancers: Because early clinical trials are often offered to patients who have already tried other more established therapies, breast cancer cells may have been pushed past an important tipping point that offers retinoic acid resis
Cancer Center study published online ahead of print in the journal Oncogene offers compelling evidence explaining this failure and offering a possible strategy for the use of retinoic acid or other retinoids against some breast
cancers: Because early clinical
trials are often offered to patients who have already tried other more established therapies, breast
cancer cells may have been pushed past an important tipping point that offers retinoic acid resis
cancer cells may have been pushed past an important tipping point that offers retinoic acid resistance.
Previous work has shown that retinoic acid, a chemical that results from the body's natural breakdown of vitamin A, should act against these CK5 +
cells, but clinical
trials of retinoids against breast
cancer have been largely unsuccessful.
Mackall's team had already designed a way to make CAR - T
cells that attack the GD2 sugar; similar anti-GD2 CAR - T
cells are now being tested in clinical
trials in a few other
cancers.
For the new
trial, hospitals enrolled patients with advanced, squamous non-small
cell lung
cancer whose disease had progressed despite initial chemotherapy.
Previous
trials of retinoids against breast
cancer have been conducted only after anti-estrogen treatments, at which point, «we were already getting expansion of
cancer stem
cells — treating with a retinoid after that was already too late,» Fettig says.
The Chinese
trial will enrol patients who have metastatic non-small
cell lung
cancer and for whom chemotherapy, radiation therapy and other treatments have failed.
«Results in Phase I
trial targeting
cancer stem
cells.»
«These are optimistic results for one of the first targeted therapies for
cancer stem cells,» says Antonio Jimeno, MD, PhD, investigator at the CU Cancer Center, director of the university's Cancer Stem Cell - Directed Clinical Trials Program, and principal investigator of the clinical trial at the CU Cancer Center
cancer stem
cells,» says Antonio Jimeno, MD, PhD, investigator at the CU
Cancer Center, director of the university's Cancer Stem Cell - Directed Clinical Trials Program, and principal investigator of the clinical trial at the CU Cancer Center
Cancer Center, director of the university's
Cancer Stem Cell - Directed Clinical Trials Program, and principal investigator of the clinical trial at the CU Cancer Center
Cancer Stem
Cell - Directed Clinical
Trials Program, and principal investigator of the clinical
trial at the CU
Cancer Center
Cancer Center site.
June is also a scientific adviser on a planned US
trial that would also use CRISPR — Cas9 - modified
cells for the treatment of
cancer.
Researchers at Dana - Farber / Boston Children's
Cancer and Blood Disorders Center report promising outcomes from a clinical
trial with patients with a rare form of bone marrow failure who received a hematopoietic stem
cell transplant (HSCT) after pre-treatment with immunosuppressive drugs only.
A phase 3
trial of lenalidomide / dexamethasone plus ixazomib (Ninlaro ®), a «proteasome inhibitor» that blocks the ability of
cancer cells to reuse certain proteins.
The researchers hope that ultimately human
trials will prove the efficacy of the OH14 compound in sensitising tumour
cells and
cancer stem
cells to existing drug - based therapies thus disabling tumours from seeding new growth after treatment.
Porter and June are now participating in a new
trial, funded by the National
Cancer Institute, that will administer about a dozen patients a fifty - fifty mixture of
cells from the Penn and Sloan - Kettering groups.
There, he guided the animal studies for Fasaret, a
cancer therapeutic that triggers
cell death, launching the product into phase I clinical
trials.
Priscilla N. Kelly Associate Editor Education: B.Sc., University of Western Australia; Ph.D., University of Melbourne Areas of responsibility: Preclinical development, translational medicine,
cancer immunotherapy, drug discovery, clinical
trials, gene and
cell therapy E-Mail:
[email protected]
Many clinical
trials combine virotherapy with chemotherapy or other immunosuppressive agents to try to allow the virus to survive and infect as many
cancer cells as possible.
The National
Cancer Institute is now funding a study to determine what specific characteristics led to that
trial's success, comparing two sets of modified immune
cells in patients.
The next step is to start clinical
trials to find out if targeting colon
cancer stem
cells in this way will result in durable cures.»
It showed effectiveness against liver
cancer in a phase II clinical
trial and will move into a phase III
trial later this year, David Kirn, an oncologist and the company's president and chief executive officer, said at a recent meeting of the American Society for Gene &
Cell Therapy in Washington, D.C..
Phase I / II clinical
trial results reported at the American Society for Clinical Oncology (ASCO) Annual Meeting 2015 show promising results for investigational drug brigatinib against ALK + non-small
cell lung
cancer (NSCLC), with 58 of 78 ALK + patients responding to treatment, including 50 of 70 patients who had progressed after previous treatment with crizotinib, the first licensed ALK inhibitor.
Combining radiation therapy with chemotherapy for patients with limited metastatic non-small
cell lung
cancer (NSCLC) may curb disease progression dramatically when compared to NSCLC patients who only receive chemotherapy, according to a new randomized phase II clinical
trial reported today at the 59th Annual Meeting of the American Society for Radiation Oncology (ASTRO).
One successful compound, named Exel 647, that targets nonsmall -
cell lung
cancer in previously untreated patients is now in a phase 2 clinical
trial.
The proposed CRISPR
trial builds off the pioneering efforts of Carl June and others at University of Pennsylvania (UPenn) to genetically modify a
cancer patient's own immune
cells, specifically a class known as T
cells, to treat leukemia and other
cancers.
Summers and the research team, led by Dr. Mike Jensen at the Ben Towne Center for Childhood
Cancer Research at Seattle Children's Research Institute, are opening PLAT - 04 after discovering that of the patients who relapsed in the PLAT - 02 trial, approximately 40 percent of them relapsed with a leukemia that evolved to circumvent the CAR T cells that were reprogrammed to detect and destroy c
Cancer Research at Seattle Children's Research Institute, are opening PLAT - 04 after discovering that of the patients who relapsed in the PLAT - 02
trial, approximately 40 percent of them relapsed with a leukemia that evolved to circumvent the CAR T
cells that were reprogrammed to detect and destroy
cancercancer.
Researchers are also working to develop a
trial where they will reprogram CAR T
cells to identify the CD19 and CD22 proteins simultaneously, enabling them to target the
cancer cells from more than one angle with the initial round of T -
cell immunotherapy.
A phase I clinical
trial conducted by investigators at the University of Texas San Antonio, showed that the combination of HCQ and the chemotherapy drug vorinostat in 27 patients with advanced solid tumors, including renal
cell carcinoma and colon
cancer, was clinically safe and inhibited autophagy.
The proposed clinical
trial, in which researchers would use CRISPR to engineer immune
cells to fight
cancer, won approval from the Recombinant DNA Advisory Committee (RAC) at the U.S. National Institutes of Health, a panel that has traditionally vetted the safety and ethics of gene therapy
trials funded by the U.S. government and others.
New results from a clinical
trial involving more than 900 military veterans at high risk for keratinocyte carcinoma skin
cancer provides evidence that using the generic skin cream fluorouacil 5 percent for two to four weeks may reduce the risk of a squamous
cell carcinoma (SCC) needing surgery by 75 percent within a year.
«Additionally, this provides evidence needed to begin investigating a vaccine in human
cancer clinical
trials to determine whether genetically modified tumor
cells producing IL - 15 and IL - 15Rα may induce anti-
cancer responses.»
The researchers tested two anti-CK2 drugs for their ability to stimulate the production of new brown fat in mice: a new small - molecule CK2 - blocker called silmitasertib (CX - 4945), which is already in clinical
trials as a
cancer therapeutic; and a more precise next - generation antisense oligonucleotide (ASO) drug developed in collaboration with Isis Pharmaceuticals, which eliminates CK2 by blocking the RNA instructions
cells use to produce it.
Previous studies have shown that a small molecule known as ONC201 currently in advanced
cancer clinical
trials, targets self - renewing colorectal
cancer stem
cells.
These findings provide further evidence of ONC201 as an inhibitor of
cancer stem
cells and support ongoing clinical
trials in prostate
cancer and glioblastoma that have shown evidence of tumor shrinkage.
Further research could test these
cancer stem
cell gene expression at the RNA and protein level in circulating tumor
cells and biopsies from patients on
trial.
Partnering with the U.S. Food and Drug Administration allowed Doebele and colleagues to access clinical
trial data describing initial tumor response, PFS and OS for 305 patients with stage IIIb or IV non-small
cell lung
cancer on
trials of ALK inhibitors and 355 similar patients on
trials of immunotherapies directed at PD - 1.