Sentences with phrase «cell circuitry»

The Center for Cell Circuitry addresses the enormous therapeutic potential of cellular circuits, which connect individual molecular components and allow cells to process signals and control decision - making.

The new centers are the Center for Cell Circuitry, the Center for HIV Cure Research, and the Center for Systems and Therapeutics.

Current explorations into the molecular underpinnings of cell circuitry are leveraging multiple data types including expression profiling and epigenetic analysis leveraging RNA - seq and CHiP - Seq coupled with molecular markers and cellular phenotypes.

The Gladstone Center for Cell Circuitry (GC3) addresses this fundamental challenge by developing single - cell tools to map how cellular components connect into circuits.

They have to piece together such molecular data to reveal whether cell circuitry is disrupted at low radiation doses.

Not exact matches

«Each area of the brain is different with distinct cell types and connectivity, so if we can confirm that one area of circuitry is more involved in a particular symptom than another, we may eventually be able to treat a depression patient more efficiently than treating everyone the same way.»

This gives just enough time for light signals from the baseball to hit the batter's eye, work through the circuitry of the retina, activate successions of cells along the loopy superhighways of the visual system at the back of the head, cross vast territories to the motor areas, and modify the contraction of the muscles swinging the bat.

The heat activates temperature - sensitive channels in the cells and stimulates potentially beneficial changes in the neural circuitry.

But scientists were stumped on how to best integrate the cell grafts into the brain's complex circuitry, where they would be more targeted and do the most good.

It consists mostly of light - sensing cells, but one tenth of a millimeter of its thickness is populated by image - processing circuitry that is capable of detecting edges (boundaries between light and dark) and motion for about a million tiny image regions.

They make myelin, the fatty coating around axons — long, threadlike fibers that relay neural impulses from one cell to the next, activating the circuitry that endows us with the physical and emotional capacity to fully embrace the world.

«Disturbances to these processes may cause neuronal stem cells to develop into different types of cells or may cause neurons to migrate to different locations in the brain, changing neuronal circuitry and potentially leading to behavioral disorders like schizophrenia.»

A study released this week in Cell reports on fruit fly neural circuitry that is affected by the drosophila equivalent of NPY — dNPF.

For his part, Collins, who has led NIH since 2009 and been kept on by the Trump administration, pointed to an array of promising NIH activities, including the development of new technologies to provide insights into human brain circuitry and function through the Brain Research through Advancing Innovative Neuroethologies (BRAIN initiative) and the use of the gene - editing tool CRISPR - Cas9 to correct mutations and clear the way to develop and test a «curative therapy» for the first molecular disease: sickle cell disease.

Somehow the rules governing synaptic connections between cells enable such «local» activity to modify the «global» neural circuitry that carries out the brain's many functions.

Sophisticated genetic circuitry spliced into cells could lead to cancer therapies, tissue generation on demand

«Just because you have the right cell type doesn't mean you have the right circuitry,» Snyder says.

Based on previous studies, researchers have hypothesized that recreational noise exposure might damage the circuitry between sensory hair cells in the inner ear and their auditory nerve targets that deliver information to the brain.

Then, using a powerful microscope that magnifies and lights up the electrical circuitry of the cells, they watched the chain of events that unfolded inside them.

As a result, the underpowered heart cells fire weakly and chaotically, forming a tiny cluster of misfiring muscle tissue, which creates a roadblock in the heart's circuitry.

We can go back and ask what cells and organs are feeding into this circuitry.»

As genetic circuitry shapes up, scientists hope the new device will make it easier for them to program cells to do things such as watch for disease, monitor pollution, or even turn on medicine output.

The characteristics of a cancer cell and its circuitry is very complex and results in many changes and mutations that allow the cells to continue to thrive despite cancer treatments,» said Laiho.

For example, the body's cells can recognize «signaling imbalances» in their own internal circuitry that might cause them to proliferate wildly, causing cancer.

In addition, Sharma says, they fine - tuned an automated microscope used to take pictures of the circuitry that had formed in the wells and calculated the numbers of synapses formed among the cells.

Cell by cell, they hope to piece together the structure's circuiCell by cell, they hope to piece together the structure's circuicell, they hope to piece together the structure's circuitry.

Using a powerful gene - hunting technique for the first time in mammalian brain cells, researchers at Johns Hopkins report they have identified a gene involved in building the circuitry that relays signals through the brain.

The three stages of CD8 + T cell development are well known, but the current study identifies a detailed map of the regulatory circuitry, such as interactions between enhancers and promoters — genetic regulatory regions that function together in driving genes to transcribe proteins to carry out biological processes.

«Importantly, the investigation also demonstrates that newly generated cells in the mouse retina not only look and behave like neurons, they also wire correctly to the existing neural circuitry at the back of the eye.»

Cells within an injured mouse eye can be coaxed into regenerating neurons and those new neurons appear to integrate themselves into the eye's circuitry, new research shows.

«We know from animal models that there are critical periods during early development when cells are rapidly dividing and forming the circuitry through which cells will communicate with each other to form various tissues of the body,» said Retha Newbold, a reproductive biologist at the National Institute of Environmental Health Sciences in North Carolina.

Scientists have tried to extend this to mammalian cells to create genetic circuitry that can help detect and treat human diseases.

This circuitry has not been integrated into living tissue, however, in part because its ability to communicate with cells is limited.

The research team selectively overexpressed a transcription factor, Klf9, only in older neurons in mice, which eliminated more than one - fifth of their dendritic spines, increased the number of new neurons that integrated into the hippocampus circuitry by two-fold, and activated neural stem cells.

What is there — a spinal cord, all major regions of the brain, multiple cell types, signaling circuitry and even a retina — has the potential to dramatically accelerate the pace of neuroscience research, said Anand, also a professor of neuroscience.

New techniques combining various staining methods with electron and light microscopy make it possible to investigate in detail the connections among nerve cells and the circuitry of the brain

These results suggest the fate of pluripotent cells may be purposely altered to generate multipotent retinal progenitor cells, which differentiate into functional retinal cell classes and form a neural circuitry sufficient for vision.

Our laboratory is interested in exploring the molecular mechanisms that drive the production of cancer stem cells and specifically in dissecting the microRNA / transcription factor circuitry that connects such differentiation metastability to tumour aggressiveness.

Such counteracting repression circuitry may be the key to understanding stem cell regulation in general, Singh said.

«We have identified the genes and growth factors involved and, thanks to a collaboration with Microsoft Research, we can now computationally model the control circuitry in mouse cells.

Now researchers led by the Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute have managed to induce a ground state by rewiring the genetic circuitry in human embryonic stem (ES) cells and in adult cells that have been induced into a pluripotent state.

Understanding the circuitry that controls these decisions is central to learning how different kinds of stem cells develop.

Now in its 6th highly successful year, the European Summer School covers fundamental concepts and examines issues in the field today, from the molecular circuitry that governs the behaviour of stem cells, to breaking therapies.

An example of this type of circuitry analysis includes measuring and interpreting all of these parameters over a time course, following stimulation of mouse bone marrow - derived dendritic cells with bacterial lipopolysaccharides (LPS) endotoxin.

Dr. Fallon's research program is primarily in four areas, including adult stem cells, chemical neuroanatomy and circuitry, higher brain functions, and brain imaging.

At any given instant it can be argued that the cell is in a «state» defined by its components — their concentrations and locations, the interactions between components — that are modulated in space and time, and the complex circuitry — that involves a large number of interacting networks and a snapshot of the dynamical processes — such as gene expression, cell cycle, transport of components, etc..

In these instances, resistance usually develops when the cancer cell's circuitry bypasses the protein that the drug acts on, or when the cell uses other pathways to avoid the point on which the drug acts.

«The ultimate goal is for the transplanted stem cells to reconstruct the brain circuitry that has been destroyed by Parkinson's and restore some function to the individual,» Mendez said.

The researchers screened 480 natural compounds and identified leelamine, derived from the bark of pine trees, as a drug that can cause this major traffic jam in the cancer cell's circuitry.

By encouraging interaction among these initiatives, researchers are learning not just how the myriad cells of the brain work individually, but how they work in concert to produce behavior — as well as how the neural circuitry of behavior is modified in response to different forms of learning.