Sentences with phrase «cell classes»

While there are no veterinary stem cell classes there are classes for humans which do stem cell research.

Our results demonstrate that pluripotent cells can be purposely altered to generate all the functional retinal cell classes necessary for vision.»

EFTF - expressing pluripotent cells form functional retinal cells and eyes when transplanted to the developing embryo, but can these induced retinal cells also differentiate into all the functional retinal cell classes in a mature normal or damaged retinal environment?

Hydrogen produced at the new facility will be used to fuel the Toyota Project Portal heavy - duty hydrogen fuel cell Class 8 trucks at its Long Beach Port facility (Credit: Toyota)

This allowed us to directly compare the patterns of marker expression in normal and induced retina, and identify cell classes on the basis of their distinctive morphology and location within the eye.

To better discern cell classes and determine how well donor cells integrated into the retina we deliberately generated mosaic eyes.

Progenitors of the central retina are the first to leave the cell cycle and differentiate into the six neuronal and one glial cell class of the mature retina.

The overview and preserved orientation in the mouse brain has enabled us to annotate additional cell classes (ependymal), glial subpopulations (microglia, oligodendrocytes, and astrocytes), and additional brain specific subcellular locations (axon, dendrite, synapse, and glia endfeet) for each investigated protein.

(K — N) Expression pattern of cell class markers is continuous through host and induced regions of mosaic retinas (see also Figure S2).

Future studies can now address how to maintain induced retinal cell cultures in a proliferative, multipotent state and drive them to all the retinal cell classes necessary to repair a damaged or degenerating mature retina.

But given the difficulty of achieving monkey chimeras from pluripotent cells, Mitalipov thinks we might need to derive an entirely new stem cell class for regenerative medicine in humans: the all - powerful totipotent cells.

Autism researchers from UCLA and Stanford will explore, among other things, forebrain spheroids, which contain the major cell classes of the developing forebrain.

The hydrogen generated on - site will be used in all Toyota fuel cell vehicles at the port, from Toyota Mirai fuel cell cars being delivered through the site, to the Toyota Project Portal heavy - duty hydrogen fuel cell Class 8 truck.

(C) Bright field image of a representative retina to illustrate the expected location and morphology of retinal cell classes.

The overall aim of this study was to determine if pluripotent cells overexpressing these transcription factors could be intentionally driven toward retinal progenitors that differentiate into multiple retinal cell classes and form a functional retina.

We show that pluripotent cells can generate all retinal cell classes.

All 31 expressed YFP throughout and molecular markers for two or more retinal cell classes.

However, it is not known if any other functional retinal cell classes can be derived from pluripotent cells, or if these cells can form the complex neural network necessary for vision.

Molecular markers for seven retinal cell classes and peripherally located mitotic cells were detected in flank retinas.

Here we provide evidence that these pluripotent cells misexpressing the EFTFs differentiate into all retinal cell classes.

If the EFTFs induce multipotent retinal progenitor cells, every retinal cell class, including retinal stem cells, should form in induced eyes.

We used immunofluorescence and in situ hybridization to detect specific retinal cell classes.

These results suggest that EFTF - expressing pluripotent cells can form eyes with the functional cell classes and circuitry necessary for phototropic behavior.

These results suggest the fate of pluripotent cells may be purposely altered to generate multipotent retinal progenitor cells, which differentiate into functional retinal cell classes and form a neural circuitry sufficient for vision.

The expression patterns of cell class - specific markers in mosaic retinas appeared the same in host and donor derived regions suggesting that donor cells generated all retinal cell classes in approximately normal ratios (Figures 5K — 5N and S2).

Normal anatomical structure and the expression of cell class - specific markers does not demonstrate normal cellular function and connectivity.

Zuber (who received a four - year, $ 200,000 Career Development Award from RPB in 2003 to pursue this investigation) and his colleagues knew that cultured pluripotent cells could be induced to express some retinal cell genes, but they didn't know if all retinal cell classes could be generated or if the cells would have the ability to form a functioning retina.

NMDA - Rs are expressed in both neurons and glia (Conti et al., 1997; Verkhratsky and Kirchhoff, 2007), and selective genetic access to these cell classes in the brain could allow for dissection of their relative role in synaptic function.