Sentences with phrase «cell contact»

Human and bacterial cells interact in a number of ways, including physical cell - to - cell contact in which molecules are passed back and forth between the cells.

Plakoglobin is a component of two important structures involved in cell - to - cell adhesion, and the investigators found that suppressing its expression caused CTC clusters to fall apart, reducing their metastatic potential, and also disrupted cell - to - cell contact between breast cancer cells but not normal breast tissue.

By analyzing the evolution over time of ft mutant cells and clones, we show that ft clones reduce their cell - cell contacts with the surrounding wt tissue in the absence of concomitant cell divisions and over-proliferation.

Notably, disruption of cell - to - cell contact effectively stopped the death of CD4 T cells.

«Although the molecular mechanisms involved in direct cell contact remain elusive, our study clearly demonstrates an important concept that dynamic communication between mOBs and mOCs regulates bone homeostasis,» corresponding author Masaru Ishii says.

mOBs and mOCs were found to mainly occupy discrete territories in the bone marrow in the steady state, although direct cell - to - cell contact exist in a spatiotemporally limited fashion.

That suggests, says Vescovi, that cell - to - cell contacts play a crucial role in determining cell type.

«Every time one fraction of the toxin acts locally (on the first nerve cell it contacts), another fraction acts at a distance,» says Chapman.

Rehman and his colleagues study mechanisms that regulate cell - to - cell contacts called adherens junctions.

Adherence of H. pylori to gastric epithelial cells is critical for induction of inflammation and injury; therefore, the overarching theme for our research has been delineation of the molecular signaling events initiated by bacterial: epithelial cell contact that regulate phenotypes related to carcinogenesis.

Surface tensions γcm from contacting blastomeres can then be used to calculate the tension along cell - cell contacts γcc by taking into account the contact angles θ.

(A) Eph receptor - ephrin binding at cell - cell contact sites results in the dimerization / clustering of Eph receptor - ephrin complexes, and initiation of canonical signals through the receptor cytoplasmic domain.

Using a dual pipette aspiration assay, the relative contribution of contractility and adhesion to cell - cell contact formation can be measured in vitro.

Combining genetics, live - imaging, laser ablation and computer simulations, we aim to analyze whether distinct or similar mechanisms can account for the common role of tumor suppressors and proto - oncogenes in cell - cell contact regulation.

T cells exert their actions in two ways, either through direct cell - cell contact which involves transmembrane proteins present on both the T cell and interacting cell, or by the secretion of soluble proteins termed cytokines which have receptors on many lymphoid and some non-lymphoid cell types.

As the cavity grows, cell - cell contacts between trophectoderm and ICM cells are broken.

Dendritic cells mediate sensory nerve innervation and regeneration through direct cell - to - cell contact and CNTF secretion.

Thus, transport of peptide — MHC II complexes by DCs not only accomplishes transfer from late endocytic compartments to the plasma membrane, but does so in a manner that selectively concentrates TCR ligands and costimulatory molecules for T cell contact.

In other cases, the genes were found to be vital for the maintenance of membranes, tissue integrity and cell - to - cell contact.

I was certainly surprised when I found the expression [production of protein] of one particular class of cadherins, N - cadherin, resulted in the disruption of cell - cell contacts.

Until recently, scientists assumed that ephrin / Eph signal transmission could only occur through direct cell - cell contact.

The bone lining cells cover the bone surfaces and contact other bone cells, such as the osteocytes that reside inside the bones, through cell - to - cell contact.

«With present technologies, the generation of a desired cell - to - cell contact is often random or limited in number,» said Benkovic.

«Acoustic tweezers manipulate cell - to - cell contact.»

The conference will also emphasize the fact that Hippo signaling sits at the interface between diverse inputs (cell - cell contacts, polarity, mechanical forces, and metabolism).

Besides infection with free virus, HIV can be transmitted also by direct cell - to - cell contact.

Cell contact, prostaglandin E (2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4 + CD25 (High) forkhead box P3 + regulatory T cells.Clin Exp Immunol 2009; 156: 149 - 160.

Experiments involving allogeneic co-cultures or MLR have demonstrated that both cell - cell contact and action by soluble factors contribute to the immunomodulatory function of MSC 106, 107, 108, 109.

These microbes have maintained an open environment - exposed cellular membrane, and Nanopusillus has developed a mechanism to acquire primary biosynthetic molecules from the host cell through cell - to - cell contact.

MSC interact with hematopoietic stem cells (HSC), influencing their homing and differentiation through cell - cell contact and the production of factors and chemokines.

The analysis of the resulting single cell data (e.g. cellular genealogy structures complemented with information on cell - cell contacts or cell migration) is done by statistical models, such as generalised linear mixed - effect models or by dynamical networks based on (cell) community structures.

Researchers highlight the importance of cell - to - cell contact in cardiosphere ‐ derived cell - mediated induction of proliferation in cardiomyocytes.

This leads to bidirectional signals emanating from Eph receptor - ephrin complexes positioned at sites of cell - cell contact.

At today's session on retroviral entry mechanisms, Clare Jolly from the University College London reported that the reason seems to be that the cell - cell contact induces polarization of the infected donor cell, in that the microtubule organizing center migrates towards the site of cell - cell contact.

As they move around looking to be completed, they bind to the cells they contact and destroy them.