Sentences with phrase «cell culture model for»

Positive data for blood brain barrier (BBB) penetration (High) were also obtained for J147 using the MDCK - MDRI cell culture model for assaying the BBB penetration potential of drugs.

Developing a three dimensional in vitro cell culture model for studying breast and prostate cancer using starPEG - heparin hydrogels.

«The model will help scientists identify new approaches to design and establish cell culture models for other human cells that previously had resisted viable culture conditions,» said Ozdener

Using high throughput robotic platforms and 3D multicellular tumor spheroid cell culture models for high throughput RNAI and drug screens for target identification and validation

Not exact matches

This study identifies myomerger as a fundmentally required protein for muscle development using cell culture and laboratory mouse models.

With our human gut - on - a-chip, we can not only culture the normal gut microbiome for extended times, but we can also analyze contributions of pathogens, immune cells, and vascular and lymphatic endothelium, as well as model specific diseases to understand complex pathophysiological responses of the intestinal tract.»

The journal's home page explains that translational medicine «builds on basic research advances — studies of biological processes using cell cultures, for example, or animal models — and uses them to develop new therapies or medical procedures.»

One postdoc presents data on her efforts to develop an organoid model for small - cell lung cancer; another reports progress on culturing hormone - secreting organoids from human gut tissue.

In 2016, the U.S. National Cancer Institute launched a scheme to develop more than 1000 cell culture models, including organoids, for researchers around the world to use, together with Cancer Research UK in London, the Wellcome Trust Sanger Institute in Hinxton, U.K., and HUB.

Existing cell culture models were not very realistic, Tuveson says, and creating genetically engineered mice took up to a year, compared with up to 3 weeks for pancreatic cancer organoids.

Using tissue culture models of cartilage and the meniscus, Levenston's team stresses the cells and tissues and studies what happens to them structurally and biochemically — for example, whether different genes are expressed, whether metabolism changes, or whether different types of cartilage cells respond differently to the same stress.

Establish infrastructure to test repurposed drugs in cell culture and animal models for potency, pharmacokinetic (PK), and pharmacodynamic (PD) studies.

Mouse embryonic stem cells stained for key pluripotency markersGRAZIANO MARTELLO Combining computer science algorithms with biological data has enabled researchers to create a model of the minimal number of factors necessary for mouse embryonic stem cells (ESCs) to self - renew in culture.

This video provides an overview of MimEX ™ Tissue Model Systems, a next - generation 3 - dimensional (3 - D) cell culture platform for the generation of ex vivo epithelial - derived organ tissue.

A549 lung epithelial cells grown as three - dimensional aggregates: alternative tissue culture model for Pseudomonas aeruginosa pathogenesis.

«Our experimental model represents a promising technique to culture human liver cells and prepare them for transplantation on a biodegradable polymer scaffold into the peritoneal cavity,» concluded Dr. Pollok.

A future aspect of our mouse work is directed towards use of ES cell differentiation in culture as a model for epigenetic decisions and stem cell manipulations.

7/16/2008 Improved Culture System for Hepatitis C Virus Infection A University of California, San Diego School of Medicine researcher has developed the first tissue culture of normal, human liver cells that can model infection with the Hepatitis C virus (HCV) and provide a realistic environment to evaluate possible... Culture System for Hepatitis C Virus Infection A University of California, San Diego School of Medicine researcher has developed the first tissue culture of normal, human liver cells that can model infection with the Hepatitis C virus (HCV) and provide a realistic environment to evaluate possible... culture of normal, human liver cells that can model infection with the Hepatitis C virus (HCV) and provide a realistic environment to evaluate possible... More...

(required) Advanced Cell Culture: 3D, Fluid Flow and Co-cultureIn Vitro Models for the Study of Neurological DiseasesStem Cells: Developing Off the Shelf TherapeuticsCreating More Realistic Gut ModelsIn Vitro Models for Animal Replacement

Ultimately, we use all this information to establish innovative culture techniques for generating unlimited neural stem cell sources for the derivation of specific types of clinically relevant neuronal or glial cells, for their use in disease modelling and drug discovery platforms, and towards refining their efficacy for future cell replacement - based therapy.

3D cell culture provides a biomimetic model of cell systems for many applications including cell / tissue models and constructs for basic / medical research, product testing, and regenerative medicine.

Enriched by the rapid evolution of these technologies, TEFOR - TACGene has developed a solid expertise in the design, production and use of TALE - N and CRISPR / Cas9 systems, both for its own research projects in cultured cells and in collaboration, in many model organisms, including the rat, zebrafish, Drosophila, and Xenopus as part of the National Infrastructure in Biology and Health TEFOR supported by Investissement d'Avenir programme (2012 - 2019).

This finding further validates our 3D cell culture devices as an experimental model for future glaucoma studies.»

That we observe cell sorting in EB culture also provides direct evidence, albeit in vitro, for the differential adhesion model proposed for the resolution of early PrEn and PrEc in the mammalian blastocyst in this same paper [56].

In the JBC article, Lipschutz and his MUSC coauthors go a step further — showing in cell culture and a zebrafish model that depletion of Tuba, a guanine nucleotide exchange factor required for Cdc42 activation, also disrupts renal ciliogenesis.

Herein, we used cell culture models of human mDA neurons to investigate a potential role for miR - 181a in mDA neurons.

The lack of accurate predictive cell culture models and the unreliability of animal studies have created a need for better approaches to recapitulate kidney function in vitro.

Viktor then applied his cell culture and model experience to create an edible and safe scaffold to support the growth of avian muscle tissue for his Senior Capstone Research Project.

Using a mouse model for this disease, which in humans involves the destruction of white matter in the brain, a research team led by Albee Messing, director of the UW — Madison Waisman Center, found that a protein behind the symptoms of the disease, called GFAP, is broken down more rapidly in the body than researchers previously found in cell culture studies.

What's more, both the cell culture and the mouse models will facilitate the identification of novel targets for PD therapy.

«Thus it seems that outside of [genetically engineered mice or a cell culture dish or other animal models] that the search for the true role of the growth potential for IGF - 1 in adult muscle hypertrophy is a vain one.»