Sentences with phrase «cell culture models»

Our approaches include gene discovery, mapping of signaling networks in cell culture models and in vivo functional analyses done through gene knock - out and knock - in techniques in mice.
The establishment of a feasible long - term taste cell culture model opens a range of opportunities to increase understanding of the sense of taste.
The scientists» model looks at the EGFR signaling cascade to investigate crosstalk between EFGR signaling and EMT in cell culture models of human breast epithelium.
Using mouse models and human cell culture models, Dr. Shresta and her team dissect the protective versus pathogenic mechanisms of the immune system in response to these viral infections.
Developing a three dimensional in vitro cell culture model for studying breast and prostate cancer using starPEG - heparin hydrogels.
December 21, 2016 — Noteworthy NIH advances in basic research include an expanded map of the human brain, nanoparticles that convert white fat to calorie - burning brown fat, and a 3 - D cell culture model of the placenta.
Raluca Constantinescu (Reichmann, TUD)-- «Oxidative stress involvement in new cell culture models of Parkinson's disease» (2007)
Existing cell culture models were not very realistic, Tuveson says, and creating genetically engineered mice took up to a year, compared with up to 3 weeks for pancreatic cancer organoids.
However, this coupling does not exist in cell culture models with exogenously expressed c - MYC — the type of systems that are mainly used to investigate glutamine addiction in cancer.
This was demonstrable in cell culture models as well as in leukemia mouse models.
Developing new cell culture models Nanomaterials end up in the environment via different pathways, inter alia the sewage system.
In the first phase of the NanoUmwelt project, the IBMT team succeeded in developing several cell culture models for the transport of nanomaterials across biological barriers.
«This connection can not be identified in animals or in two - dimensional cell culture models
Positive data for blood brain barrier (BBB) penetration (High) were also obtained for J147 using the MDCK - MDRI cell culture model for assaying the BBB penetration potential of drugs.
Utilizes spontaneous and CRISPR / Cas9 generated mouse lines along with primary cell culture models to look at the molecular intersection between the motor neuron and heart phenotypes in mouse models of Spinal Muscular Atrophy with Respiratory Distress (SMARD).
His team is using innovative cell culture models to advance our understanding of brain stem cells and their potential role in glioblastoma.
«The model will help scientists identify new approaches to design and establish cell culture models for other human cells that previously had resisted viable culture conditions,» said Ozdener
In addition to characterizing this heterogeneous disease, we have identified representative cell culture models that display differential drug sensitivity.
Using high throughput robotic platforms and 3D multicellular tumor spheroid cell culture models for high throughput RNAI and drug screens for target identification and validation
The lack of accurate predictive cell culture models and the unreliability of animal studies have created a need for better approaches to recapitulate kidney function in vitro.
He is also developing a robust and comprehensive panel of 3 - D cell culture models from patient - derived primary cells that can be used to characterize different disease phenotypes and investigate the chemo - response of cells to novel or known drugs.
The compound, which was tested in cell culture models of c9FTD / ALS, bound to and blocked RNA's ability to interact with other key proteins, thereby preventing the formation of toxic RNA clumps and «c9RAN proteins» that results from a process called repeat - associated non-ATG (RAN) translation.
Studies are underway to define the particular interferon regulatory factor and ISG mechanisms through which both the STAT1 - dependent and STAT2 - independent pathways contribute to protection vs. pathogenesis using both mouse models and human cell culture models.
Critically, despite the detection of enhanced Zika infection in cell culture models using antibodies from macaques previously exposed to either yellow fever or dengue and then exposed to Zika, there were no signs of enhanced Zika infection seen in these macaques themselves.
Researchers took biopsies from 71 colorectal cancer patients and made «cancer organoids,» or cell culture models of cancerous organs.
Often times we'll use an animal model or cell culture model to test a bioactive to see if it has efficacy.
«We compared the ability of RSV and parainfluenza virus (PIV3)-- another common virus in children that causes much less severe airway disease — to infect and cause inflammatory responses in a cell culture model of human epithelial cells, which compose the lining of the lung airway.
In 2016, the U.S. National Cancer Institute launched a scheme to develop more than 1000 cell culture models, including organoids, for researchers around the world to use, together with Cancer Research UK in London, the Wellcome Trust Sanger Institute in Hinxton, U.K., and HUB.
«It is difficult to say what the long - term effects of nanoparticle ingestion are on human health, especially based on results from a cell culture model,» said Mahler.
«To do that, we went back to the cell culture model to ask whether or not the antibody basically prevents the uptake of misfolded α - syn.»
We have been using cell culture models and zebrafish as an assay to determine the effects of BMP on signaling, but we also want to be able to understand what the effect of the mutation is in the tissue and organ systems.
My laboratory is studying the impact of recombinant ApoA - I - Milano protein on a cell culture model that mimics the environment of blood vessels in the human brain.
Nicola Watt (Reichmann, TUD)-- «Mitochondrial dysfunction and lipid metabolism in cell culture models of respiratory chain and neurodegenerative diseases» (2007)
Their results, published in Emerging Infectious Diseases, demonstrate that the highly differentiated 3 - D cell culture model can support the natural growth of human noroviruses, whereas previous attempts using differentiated monolayer cultures failed.
We are interested in the role of secretory chaperones in the biochemistry and cell biology of the neuron and have shown that two small secretory chaperones can block the formation of both Abeta oligomers and fibrils in vitro and neurootoxic aggregates in cell culture models.
His postdoctoral work focuses on investigating novel molecular regulatory pathways involved in mitigating genotoxic stress using Drosophila melanogaster and human cell culture model and cellular senescence.
I completed my Ph.D. in Microbiology in November 2016 from the University of Kansas after researching host cell - viral interactions of HSV - 1 in cell culture models.
The study was done using an in vitro (i.e. «in glass» or test - tube) cell culture model of the small intestinal epithelium.
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