Antioxidants have been shown to reduce bio-markers of oxidative cell damage
in cell culture systems, as well as in many animal models and human studies.
Many life - saving products, such as recombinant therapeutic proteins, vaccines, and gene therapy vectors, are produced from large -
scale cell culture systems.
Therapeutic applications of CRISPR - Cas gene editing are being advanced with the goals of finding cures and treatments for a range of serious diseases, developing needed medicines for both household pets and production animals, and
improving cell culture systems for bioproduction.
It facilitates self - renewal of both pluripotent human embryonic stem cells and induced pluripotent stem cells in a chemically defined, feeder - free and animal - protein
free cell culture system.
Now that they have a reliable human beige
fat cell culture system, Kajimura said, his team will be able to use the system as a screening platform to identify and test small molecules that activate the development, differentiation, and thermogenic (heat - producing) activity of human brown fat.
The researchers then used a 3 -
D cell culture system to coax their mutant and healthy hPSCs down the differentiation pathway into becoming kidney progenitor cells and finally the proximal tubule cells found in kidney nephrons.
The Duke team used an
established cell culture system to determine whether and how the hUTCs might affect the growth of neurons isolated from the retinas of rat eyes.
Stem cell or tissue - derived multi-cellular 3D organoids, also referred to as mini-organs or organs in a dish, provide superior in vitro models for studying human diseases and performing drug screening, as compared to conventional
2D cell culture systems.
Specifically, the Ignatius laboratory will study tumorigenic cell populations that self - renew and metastasize using a combination of zebrafish, murine xenograft and
human cell culture systems.
From numerous studies in the Xenopus paired oocyte system and
various cell culture systems, a reasonable assumption might be that if two cells express the same connexin or innexin and lie in close membrane apposition, gap junctions will probably be established between them; this assumption has not been investigated rigorously in vivo.
Recruiting Volker was one of the biggest strokes of luck in my scientific life as he was not only the key person to set up the first
HCV cell culture system, but also an exceptional mind creating true team spirit and synergy within the research team.
Our goal is to create a microfluidic 3D
cell culture system representing a «placenta - on - a-chip» in order to mimic the nutrient / waste transfer between maternal blood and fetal blood that occurs in the cotyledon section of the placenta, and to test and observe the effects of ethanol within the maternal bloodstream and compare it to a similar in vivo situation.
Glutamine addiction has often been studied
in cell culture systems that are genetically altered to overproduce c - MYC, a central regulator of growth and proliferation in all cells that is frequently de-regulated in cancers.
In the health care industry, many life - saving products, such as recombinant therapeutic proteins, vaccines, and gene therapy vectors, are produced from large -
scale cell culture systems.
«Our application of this technology is powerful because it allows us to identify specific neural stem cell defects that are invisible in
the cell culture systems typically used by brain scientists.
To evaluate the efficacy of this new compound, the researchers first tested it using
a cell culture system to evaluate melanoma cell biology in vitro and found a variety of cancer - associated processes were affected, including cellular growth, differentiation and migration.
In
the cell culture systems, c - MYC protein will always be at a high level.
Moreover, the researchers discovered that
cell culture systems that express excess c - MYC and naturally occurring colon carcinoma cells differ in the way c - MYC production is regulated.
«The fact that glutamine addiction has mainly been investigated in
cell culture systems may have overestimated the lethality of glutamine deprivation,» said Martin Eilers, University of Würzburg, who led the study together with Kempa.
ECVAM advocates the integrated use of alternative methods in intelligent testing strategies, such as the combined use of computer models based on quantitative structure - activity relationships (QSARs) and
cell culture systems.
We thank Dominic Fan and Ewa Kruzel for sharing their expertise in
cell culture systems, Walter Pagel for critical editorial review, and Lola López for expert assistance in the preparation of this manuscript.
«It is difficult to know whether the anti-amyloidogenic effect of resveratrol observed in
cell culture systems can support the beneficial effect of specific diets,» Marambaud explains.
The cell culture system described here provides, for the first time, a means with which to perform controlled detailed examinations on both the activated and differentiated phenotype of organ - specific microvascular endothelial cells.
With this information, they turned to
a cell culture system to see if any Cpf1 nucleases would exhibit in vivo activity in mammalian cells.
Some phthalates also act as weak estrogens in
cell culture systems.
In the absence of GFP, no reporter output was observed in their 293
cell culture system.
Flavonoids have been shown to reduce biomarkers of oxidative cell damage in
cell culture systems, animal models and human studies.