Sentences with phrase «cell cycle arrest»

Inhibition of mTOR induces cell cycle arrest in ALCL cells.

Inhibition of mTOR induces cell cycle arrest in ALK + ALCL cells.

These results suggest that inhibition of mTOR - raptor complex or silencing mTOR gene expression induced cell cycle arrest at G1 phase in ALK + ALCL cells.

They further show that this diterpine downregulates HMG CoA reductase offering support to the concept that mevalonate deprivation causes cell cycle arrest at the G1 phase leading to apoptotic death of the prostate carcinoma cells.

Two newly synthesized 5 - methyltetrahydrofolate - like compounds inhibit methionine synthase activity accompanied by cell cycle arrest in G1 / S phase and apoptosis in vitro.

Cell cycle studies also showed that inhibition of mTOR function by using rapamycin or inhibition of mTOR expression by using mTOR - specific siRNA induced cell cycle arrest as shown by a dose - dependent decrease of cell cycle S phase (data not shown).

Results show that one night of partial sleep deprivation activates gene expression patterns in peripheral blood mononuclear cells (PBMCs) consistent with increasing accumulation of damage that initiates cell cycle arrest and increases susceptibility to senescence.

GHRH antagonist causes DNA damage leading to p21 mediated cell cycle arrest and apoptosis in human colon cancer cells.

The research group in Israel showed «that the Spalax p53 suppresses apoptosis (programmed cell death), however enhances cell cycle arrest and DNA repair mechanisms,» he said.

Researchers at Texas Woman's University have shown that a diterpene geranylgeraniol found in linseed oil, Cedrela toona wood oil, sucupira branca fruit oil and more recently, annatto seed oil, suppressed the viability of human DU145 prostate carcinoma cells via cell cycle arrest at the G1 phase and the initiation of apoptosis.

C. Geminin / Ki67 assay to assess cell cycle arrest in vivo.

Resistance to DNA - damaging treatment in non-small cell lung cancer tumor - initiating cells involves reduced DNA - PK / ATM activation and diminished cell cycle arrest.

Thus, MyoD may induce terminal cell cycle arrest during skeletal muscle differentiation by increasing the expression of p21.

To evaluate the molecular basis underlying cell cycle arrest after inhibition of mTOR, we assessed several cell cycle regulatory proteins after treatment with rapamycin or specific mTOR siRNA.

We also show that inhibition of mTOR expression or activity markedly decreased activation of the mTOR pathway associated with cell cycle arrest and apoptosis in ALK + ALCL cells.

MiRNA -362-3p induces cell cycle arrest through targeting of E2F1, USF2 and PTPN1 and is associated with recurrence of colorectal cancer.

We are studying the mechanisms that maintain multipotent cell fate during quiescence (reversible cell cycle arrest) using C. elegans as a model for aging stem cells.

Other research confirmed tocotrienol's protective effects on normal cells, with researchers reporting that the vitamin reversed cell cycle arrest and reduced DNA damage.

Adenine causes cell cycle arrest and autophagy of chronic myelogenous leukemia K562 cells via AMP - activated protein kinase signaling.

In addition, they found that epithelial - derived MMP9 suppresses tumors in CAC by activating the MMP9 - Notch1 - ARF - p53 axis pathway, which increases apoptosis, initiates cell cycle arrest and keeps a check on DNA damage.

Furthermore, Dr. Loftus» group has demonstrated that reduced SOX10 expression in melanoma cells confers reduced cell proliferation, induces marks of cell senescence and leads to cell cycle arrest in melanoma cells.

Our findings show that treatment of both cell lines with increasing concentrations of LY294002 led to cell cycle arrest as shown by decreased cell cycle S - phase fraction in a dose - dependent manner (Supplementary Fig.

Sulforaphane induces cell cycle arrest by protecting RB - E2F - 1 complex in epithelial ovarian cancer cells.

Human colon carcinoma cells that overexpressed MMP9 showed decreased cell proliferation, less DNA damage and cell cycle arrest in the S - phase to prevent cell proliferation.

«While it was known that palbociclib stalls proliferation by inhibiting CDK4 / 6, inducing proteasomal activity may be an additional mechanism that ensures the completeness of the cell cycle arrest,» says Dr. Mikael Björklund, one of the lead authors of the study.

It induces cell cycle arrest and senescence, an irreversible resting state marking these «out - of - order» cells to be cleared by the immune system.

Furthermore, niclosamide inhibited not only signal transduction, but also targeted mitochondria in cancer cells resulting in cell cycle arrest, growth inhibition and apoptosis [49 - 51].

Previously published retrospective clinical studies and in vitro data regarding the association of radiotherapy with inhibitors of mutant BRAF kinase (vemurafenib) suggest a radiosen - sitization (cell cycle arrest in G1, DNA repair decrease, restore dradiation - induced apoptosis) and an increased radiation - induced toxicity [56, 58].

This cell cycle arrest in the G0 phase requires the retinoblastoma tumor suppressor protein (Rb).

Cell cycle arrest was associated with modulation of G1 - S - phase regulators, including the cyclin - dependent kinase inhibitors p21waf1 and p27kip1.

We also show that rapamycin and total mTOR silencing induces cell cycle arrest and apoptosis interfering with proliferation and survival pathways in ALK + ALCL.

We also show that inhibition of mTOR with rapamycin, as well as silencing mTOR gene product expression using mTOR - specific small interfering RNA, decreased phosphorylation of mTOR signaling proteins and induced cell cycle arrest and apoptosis in ALK + ALCL cells.

Shapiro GI, Koestner DA, Matranga CB, et al: Flavopiridol induces cell cycle arrest and p53 - independent apoptosis in non-small cell lung cancer cell lines.

The restriction of cellular growth by p53 has been reported to result in cell cycle arrest or apoptosis [6], and targeting p53 and restoring p53 function to limit tumor growth has been intensively researched for cancer therapy [7].

It has been shown that the MAP kinases including JNKs, ERKs, and p38 phosphorylate p53 in response to different stressful stimuli, and in turn, activate a p53 response leading to cell cycle arrest and apoptosis [24].

TGFβ inhibits tumor initiation and progression by inducing cell cycle arrest and apoptosis; however epithelial tumorigenesis may escape this common antitumor mechanism by inducing aberrations in TGFβ signaling resulting in enhanced development and progression of human carcinomas.

This fibroblast «quiescence program» contained genes that enforced the non-dividing state, and ensured the reversibility of the cell cycle arrest.

In a study published in BMC Cancer, researchers noted that a combination of resveratrol and pterostilbene helped to down - regulate a sirtuin molecule called SIRT1 — combating breast cancer cells by interfering with their telomerase activity, inhibiting their growth and causing cell cycle arrest.

González - Sarrías, A.; Ma, H.; Edmonds, M.E.; Seeram, N.P. Maple polyphenols, ginnalins A-C, induce S - and G2 / M - cell cycle arrest in colon and breast cancer cells mediated by decreasing cyclins A and D1 levels.

González - Sarrías, A.; Li, L.; Seeram, N.P. Effects of maple (Acer) plant part extracts on proliferation, apoptosis, and cell cycle arrest of human tumorigenic and non-tumorigenic colon cells.

González - Sarrías, A.; Li, L.; Seeram, N.P. Anticancer effects of maple syrup phenolics and extracts on proliferation, apoptosis, and cell cycle arrest of human colon cells.

✓ Cytotoxicity — WGA has been demonstrated to be cytotoxic to both normal and cancerous cell lines, capable of inducing either cell cycle arrest or programmed cell death (apoptosis).