Sentences with phrase «cell cycle by»

Our «biased» profiling is based on an in vitro model of mouse terminally differentiated myotubes, induced to re-enter the cell cycle by the E1A oncogene (23).

Jana Sontheimer (Pisabarro, TUD)-- «Functional characterization of proteins involved in cell cycle by structure - based computational methods» (2012)

This study, which will be published Oct. 24 in eLife, and two other new Northwestern studies in Oncotarget and Cell Cycle by the Peter group, describe the discovery of the assassin molecules present in multiple human genes and their powerful effect on cancer in mice.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

The protein is now known to interact with and control dozens of different genes and proteins, and it helps regulate the cycle of molecular events by which cells grow and reproduce.

The study found that carfilzomib and irinotecan have a potential synergistic effect in SCLC and other Irinotecan - sensitive cancers by allowing normal DNA damage repair and enabling normal cell - cycle death.

EPFL biologists and geneticists have uncovered how the circadian clock orchestrates the 24 - hour cycle of gene expression by regulating the structure of chromatin, the tightly wound DNA - protein complex of the cell.

«The overall sun - to - electricity efficiency of the hydricity process, averaged over a 24 - hour cycle, is shown to approach 35 percent, which is nearly the efficiency attained by using the best photovoltaic cells along with batteries,» Gençer said.

The role of DNA topology in holding sister chromatids together before anaphase was investigated by analyzing the structure of a small circular minichromosome in cell cycle (cdc) mutants of the yeast Saccharomyces cerevisiae.

Normal SCN cells in the lab keep cycling in synchrony without regard to temperature pulses, but research from another group showed that they could be «reset» by temperature changes if they could no longer signal to each other.

Cyclin D is synthesized during the first stage of cell replication and is believed to help drive the complex, multi-stage process, including interaction with the retinoblastoma (Rb) protein, whose function is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide.

By copying the gene for Spo0F (purple) early in the cell - division cycle and the gene for KinA (green) later in the cycle, the bacteria assure that the decision to form a spore or divide is made when DNA replication has completed.

Igoshin said that when the researchers set out to find how sporulation decisions were timed to the cell cycle, several studies including prior work by team members, provided a significant clue: Under starvation conditions, the activity of the master regulator gene had been shown to spike once per cell cycle.

Endometriosis is caused by uterus lining (endometrium) cells moving elsewhere in the body where they can compress nerves and bleed in time with a woman's menstrual cycle.

In fact, the researchers showed that the synthesis of the capsule is controlled by the same mechanisms that regulate the cell cycle, and identified the protein that inhibits the production of the sugar capsule in one of the daughter cells.

Endometriosis is caused by uterus cells moving elsewhere in the body and bleeding in time with a woman's menstrual cycle.

First, imaging experiments revealed that Tregs have a close relationship with the stem cells that reside within hair follicles and allow them to regenerate: the number of active Tregs clustering around follicle stem cells typically swells by three-fold as follicles enter the growth phase of their regular cycle of rest and regeneration.

In healthy human cells, the p53 protein helps prevent tumors by putting the brakes on the cell cycle to give an ailing cell time to fix itself — or die — rather than spawning more corrupted cells.

It also undergoes cell division by first creating copies of chromosomes like most human cells and has a very fast replication cycle, all of which facilitated the study.

The studies on autophagy by Yoshinori Ohsumi, which earned him the Nobel Prize in Medicine in 2016, and the discovery of cell cycle regulatory genes for which Leland Hartwell, Timothy Hunt and Paul Nurse received the same award in 2001, including the research of Elizabeth Blackburn, Carol Greider and Jack Szostak on telomeres, telomerase and its protective effect on the chromosomes, were all made possible thanks to yeast.

In addition, they found that epithelial - derived MMP9 suppresses tumors in CAC by activating the MMP9 - Notch1 - ARF - p53 axis pathway, which increases apoptosis, initiates cell cycle arrest and keeps a check on DNA damage.

In the first cell cycle after fertilization the maternal genome inherited from the oocyte (egg) and the paternal genome provided by sperm exist as separate nuclei in the zygote.

«Our study found that by introducing an inhibitor of the STAT3 protein in repeated cycles, we could alternately replenish the pool of satellite cells and promote their differentiation into muscle fibers,» said Alessandra Sacco, Ph.D., assistant professor in the Development, Aging, and Regeneration Program at Sanford - Burnham.

Moreover, even if the Foxo1 - deficient B cells could be manipulated to be selected by the TFH cells, they still did not proliferate, suggesting another factor besides Foxo1 is also imperative to cycling.

Some of the common genetic alterations identified in the study were gains and losses in chromosome 8, as well as cell proliferation and cell - cycle progression — key mechanisms of cancer caused by genetic alterations — linked to the genes AURKA, AURKB and FOXM1.

By STEPHEN YOUNG Few phenomena in biology are quite as dramatic as the cell cycle, the ordered sequence of events by which cells grow and dividBy STEPHEN YOUNG Few phenomena in biology are quite as dramatic as the cell cycle, the ordered sequence of events by which cells grow and dividby which cells grow and divide.

«The cancer stem cells actively regrow and respond to the induced damage or apoptosis (cell death) caused by chemotherapy in between the different cycles, similar to how normal tissue stem cells respond to wound - induced damages.»

While looking carefully at the areas of cell destruction induced by the viruses — called plaques — he and colleagues noticed that vaccinia spread four times faster than its replication cycle would allow.

C. albicans is known to undergo a parasexual cycle involving heterothallic fusion of α and a mating type cells followed by stochastic, concerted loss of chromosomes [44].

In fact, KLF4 blocks senescence and apoptosis by repressing transcription of P53, whereas it can activate P21 - dependent cell - cycle arrest, and therefore, KLF4 can function both as a tumor suppressor and an oncogene (33, 34).

They will follow this approach to design a novel treatment plan by rationally combining gemcitabine with cell cycle checkpoint inhibitor, oxygen - enrich gas inhalation, and radiotherapy to significantly inhibit the growth of aggressive glioma.

They inhibit viral infection by preventing viral entry into target cells and by blocking different stages of the viral replicative cycle for different viruses.

They also investigated a new strategy to significantly inhibit glioma growth by rationally combining gemcitabine and MK - 8776, a cell cycle checkpoint inhibitor.

The researchers plan to use the new platform to identify additional weaknesses in the HIV virus's life cycle that could be exploited either by cell therapy or targeted drugs.

«While it was known that palbociclib stalls proliferation by inhibiting CDK4 / 6, inducing proteasomal activity may be an additional mechanism that ensures the completeness of the cell cycle arrest,» says Dr. Mikael Björklund, one of the lead authors of the study.

Check a review on integrative view of cell cycle control in E. coli by L. Dewachter, an article on the return of cultures in microbiology by V. Marx, an article on microbial altruism and cheating in social amoebas by S. Noh.

Cell cycle - dependent regulation of the forkhead transcription factor FOXK2 by CDK - cyclin complexes.

It induces cell cycle arrest and senescence, an irreversible resting state marking these «out - of - order» cells to be cleared by the immune system.

They found that like bacteria and budding yeast, H. salinarum controls its size by adding a constant volume between two events in the cell cycle.

Key findings of this research, which was conducted by Shawn L. Chavez, PhD and her colleagues at Stanford University and analyzed at OHSU, showed that by looking at the duration of the first mitotic phase — a short period in the cell cycle — one can identify chromosomally normal versus abnormal embryos up to approximately the 8 - cell stage.

The study, commissioned by CHEOPS - a perovskite research project co-funded by the European research and innovation programme Horizon 2020, is being conducted by SmartGreenScans, a CHEOPS member, specialising in Life - Cycle Assessments (LCA) of photovoltaic technologies, to assess the life - cycle environmental impact of the perovskite - on - silicon tandem cells being commercialised by OxforCycle Assessments (LCA) of photovoltaic technologies, to assess the life - cycle environmental impact of the perovskite - on - silicon tandem cells being commercialised by Oxforcycle environmental impact of the perovskite - on - silicon tandem cells being commercialised by Oxford PV.

His group is are studying the mechanism of stable inherited epigenetic transcriptional repression by Polycomb - group (Pc - G) protein complexes, and the effects of deregulation of Pc - G genes on Homeobox gene expression, development, Cell cycle control and cancer formation.

Thus, MyoD may induce terminal cell cycle arrest during skeletal muscle differentiation by increasing the expression of p21.

The function and dynamics of the apical scaffolding protein E3KARP are regulated by cell - cycle phosphorylation.

The Institute is currently running on a Site License by Flowjo, a flow cytometry data analysis software package which offers a range of analysis platforms that includes compensation, cell cycle, proliferation studies and kinetics.

Hall and Rosbash then discovered a protein, named PER, that was made by the period gene, and figured out how it worked through a feedback mechanism — its own expression in the cell would cause PER to build up in the nucleus and would eventually effectively shut off the period gene, allowing it to cycle on and off on a daily schedule.

The major mechanism of B cell suppression by MSCs is attributed partly to the physical contact between MSCs and B cells and in part to the soluble factors released by MSCs; this leads to the blocking of B cell proliferation in the G0 / G1 phase of the cell cycle with no apoptosis 28, 29, 30.

Panel D. mRNA expression analysis of urea cycle enzymes, as quantified by transcriptome analysis, was performed in enhanced hiPS - HEP cells from C12, C18, and C22 on Day 13 post-thawing (n = 2 batches per cell line) and compared to hphep cells on Day 1 post-thawing (n = 3 donors).

Ninov N., Manjón C., and Martín - Blanco E. Dynamic control of cell cycle and growth coupling by ecdysone, EGFR, and PI3K signaling in Drosophila histoblasts.

At any given instant it can be argued that the cell is in a «state» defined by its components — their concentrations and locations, the interactions between components — that are modulated in space and time, and the complex circuitry — that involves a large number of interacting networks and a snapshot of the dynamical processes — such as gene expression, cell cycle, transport of components, etc..