Sentences with phrase «cell cycle checkpoint»

The role of cell cycle checkpoint proteins is to integrate internal and external factors to determine whether the cell is prepared for progression of the cell cycle.

They also investigated a new strategy to significantly inhibit glioma growth by rationally combining gemcitabine and MK - 8776, a cell cycle checkpoint inhibitor.

They will follow this approach to design a novel treatment plan by rationally combining gemcitabine with cell cycle checkpoint inhibitor, oxygen - enrich gas inhalation, and radiotherapy to significantly inhibit the growth of aggressive glioma.

Relative contribution of DNA repair, cell cycle checkpoints, and cell death to survival after DNA damage in Drosophila larvae.

They speculate that because the process of reprogramming increases the number of cell divisions that take place (as compared to what happens in adult skin cells), there are more opportunities for the cell cycle checkpoints to correct for the chromosomal breakage.

Not exact matches

These experiments were essential to understanding the effect of gemcitabine on cell cycle and the effective scheduling of checkpoint inhibitor for maximal malignant cell kill.

Some examples of such processes are signal transduction pathways, the cell cycle and checkpoints, and apoptosis.

In response to DNA damage, the checkpoint regulates and coordinates many cellular processes critical for genomic stability, including cell cycle progression, DNA repair, DNA replication, and apoptosis.

Finally, we show that inactivation of DNA damage checkpoint kinases in senescent cells can restore cell - cycle progression into S phase.