Sentences with phrase «cell cycle pathways»

45) * Coe BP, * Lockwood WW, Girard L, Chari R, MacAulay C, Lam S, Gazdar AF, Minna JD, Lam WL (2006) Differential regulation of cell cycle pathways in small cell and non-small cell lung cancer.

A broad range of biological processes, molecular functions, cell cycle pathways (Supplementary Table S5) and gene sets from the MSigDB (Supplementary Table S6) was enriched across these different modules.

Not exact matches

PAK proteins allow melanoma to thrive through their action on a few different pathways, both encouraging cell cycle progression and inhibiting apoptosis, a form of cell death, the researchers found.

He hopes to pursue projects such as developing therapeutics with chemists, working with biophysicists to study protein conformational changes relevant to viral entry into the cell, and investigating cellular trafficking pathways relevant to the viral life cycle in collaboration with cell biologists.

In addition, they found that epithelial - derived MMP9 suppresses tumors in CAC by activating the MMP9 - Notch1 - ARF - p53 axis pathway, which increases apoptosis, initiates cell cycle arrest and keeps a check on DNA damage.

LA JOLLA, CA — A team of scientists at the Salk Institute for Biological Studies has identified why disruption of a vital pathway in cell cycle control leads to the proliferation of cancer cells.

A Human Long Non-Coding RNA ALT1 Controls the Cell Cycle of Vascular Endothelial Cells Via ACE2 and Cyclin D1 Pathway.

Moreover; the PI3K / AKT pathway also can contribute to melanoma tumorigenesis through mutations or loss in PTEN and dysregulation in expression of AKT, which positively regulates the G1 / S phase progression in cell cycle, suppresses apoptosis and promotes cellular survival.

MSC influence control over cell division cycle pathways in cells of immunological relevance.

For instance, in the case that nicotinic acid or nicotamide are deficient in the cell, NAD + is synthesized from alternative pathways such as L - tryptophan cycle.

PK is a gatekeeper that helps determine whether a cell metabolizes glucose using the TCA cycle or diverts it to other pathways for anabolic growth.

We also show that rapamycin and total mTOR silencing induces cell cycle arrest and apoptosis interfering with proliferation and survival pathways in ALK + ALCL.

Altieri and his team are currently focused on three programs to understand the biology of survivin with respect to cell cycle progression, in particular, mitosis, cell survival and the cellular stress response and how exploiting these pathways may provide new cancer therapeutics.

Activation of these pathways further leads to the activation of multiple transcription factors, pro- and antiapoptotic proteins, cell cycle check point proteins, etc. [4, 6, 8].

These pathways function in the inhibition of apoptosis as well as cell differentiation and cell cycle.

Countering the prevailing theory that cellular hydrogen peroxide signaling is broad and non-specific, Whitehead Institute scientists have discovered that this reactive oxygen species (ROS) in fact triggers a distinct signal transduction cascade under control of the mitochondrial respiratory chain — the Syk pathway — that regulates transcription, translation, metabolism, and the cell cycle in diverse cell types.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Some examples of such processes are signal transduction pathways, the cell cycle and checkpoints, and apoptosis.

Like in the Wnt signaling pathway, ligands bind to the EGFR on the cell surface and initiate a cascade of events in the cell that in this case lead to regulation of genes that control cell cycle progression.

Many of these kinases are involved in growth - related pathways, tumorigenesis pathways, and cell cycle control, such as Aurora kinase B (Borisa and Bhatt, 2017).

The table below lists the genes from the Cell Cycle and Apoptosis KEGG pathways that are expressed at day 0 and day 10.

Wnt / b - catenin / Tcf1 pathway controls mouse embryonic stem cell cycle progression and proliferation by regulating the Ink4 / Arf locus.

Figure 7 depicts a stationary view of the KEGG pathways for «Cell Cycle» and «Apoptosis» at three time points; it appears that ES cells (day 0) have higher numbers of expressed genes involved in cell cycle (rectangles in red color) compared to differentiated cells (day Cell Cycle» and «Apoptosis» at three time points; it appears that ES cells (day 0) have higher numbers of expressed genes involved in cell cycle (rectangles in red color) compared to differentiated cells (dayCycle» and «Apoptosis» at three time points; it appears that ES cells (day 0) have higher numbers of expressed genes involved in cell cycle (rectangles in red color) compared to differentiated cells (day cell cycle (rectangles in red color) compared to differentiated cells (daycycle (rectangles in red color) compared to differentiated cells (day 10).

Tcf3 and Tcf1 are two key effectors in the pathway, and are essential in this process (Lluis et al., PNAS 2011; Ombrato et al., Cell Cycle 2012; Aulicino et al., Stem Cell Report 2014).