Sentences with phrase «cell cycle progression»

Ralf Kittler (Buchholz, MPG)-- «Functional genomic analysis of cell cycle progression in human tissue culture cells» (2006)

«It completely turns upside - down what was thought to be a fundamental aspect of cell cycle progression in all cancer cells driven by one of the most common genetic pathways mutated in cancer, namely the p16 - cyclin D pathway.»

Once freed, the proteasome degrades proteins required for cell cycle progression, thus driving cells into senescence.

Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation.

Dowdy and colleagues painstakingly counted the number of phosphates added to Rb during cell cycle progression.

Palbociclib has been designed to thwart tumor growth by preventing key molecules of cell cycle progression from doing their job.

Like in the Wnt signaling pathway, ligands bind to the EGFR on the cell surface and initiate a cascade of events in the cell that in this case lead to regulation of genes that control cell cycle progression.

PAK proteins allow melanoma to thrive through their action on a few different pathways, both encouraging cell cycle progression and inhibiting apoptosis, a form of cell death, the researchers found.

Cyclin D is synthesized during the first stage of cell replication and is believed to help drive the complex, multi-stage process, including interaction with the retinoblastoma (Rb) protein, whose function is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide.

Researchers at the University of California, San Diego School of Medicine say a protein essential to regulating cell cycle progression — the process of cell division and replication — activates a key tumor suppressor, rather than inactivating it as previously thought.

Silvia Prenninger (Calegari, TUD)-- «Unraveling the molecular mechanisms underlying cell cycle progression and differentiation of neural progenitor cells during mouse brain development» (2011)

Furthermore; p16INK4a inhibits CDK4 and CDK6, and induces phosphorylation of the protein retinoblastoma (Rb) and liberating the transcription factor E2F which consequently result in cell cycle progression [29].

By using a mouse model of conditional APC gene deletion in MuSCs we further demonstrated that the massive activation of canonical Wnt signaling in MuSC following APC loss results in defective cell cycle progression and apoptosis.

Inhibition of mTOR expression or function blocked cell cycle progression from G1 to S phase associated with modulation of the CDK inhibitors p21waf1 and p27kip1.

Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation.

Our favorite experimental system is the Xenopus egg extract system for studies on cell cycle progression and regulation, microtubule dynamics, spindle assembly and chromosome behaviour (Karsenti and Vernos, 2001).

In response to DNA damage, the checkpoint regulates and coordinates many cellular processes critical for genomic stability, including cell cycle progression, DNA repair, DNA replication, and apoptosis.

Wnt / b - catenin / Tcf1 pathway controls mouse embryonic stem cell cycle progression and proliferation by regulating the Ink4 / Arf locus.

The research team at Mainz University speculates that whilst entanglements between chromosomes need to be removed for cell cycle progression those within a chromosome may not affect function and transmission of genetic information.

Conserved antagonism between JMJD2A / KDM4A and HP1γ during cell cycle progression.

Researchers describe how a microRNA can affect both pluripotency and cell cycle progression in human pluripotent stem cells

There are as many as 14, but the scientists found that cyclin D adds just a single phosphate at one, and only one, of the 14 locations during the early G1 phase of cell cycle progression, essentially make 14 different versions of the Rb tumor suppressor.

This is the first demonstration of TBK1 regulating mitosis and cell cycle progression.

This study, published recently in PLOS Genetics, shows that in the particular case of meiotic cells such as spermatocytes, the signalling route of the ATM protein also participates in the control system of the cell cycle progression in response to DNA damage, something which until now was unknown.

Emk is a serine / threonine protein kinase implicated in regulating polarity, cell cycle progression, and microtubule dynamics.

Zutter, MM, Santoro, SA, Wu, JE, Wakatsuki, T, Dickeson, SK, Elson, E. Collagen receptor control of epithelial morphogenesis and cell cycle progression.

Also, the expression of NUDIX in normal and cancer tissues, and how knock - down of these enzymes affected proliferation and cell cycle progression in both cases, were investigated.

Lee Y, Dominy JE, Choi YJ, Jurczak M, Tolliday N, Camporez JP, Chim H, Lim JH, Ruan HB, Yang X, Vazquez F, Sicinski P, Shulman GI, Puigserver P. Cyclin D1 - Cdk4 controls glucose metabolism independently of cell cycle progression.

Activated ERK1 / 2 modulates the functions of several transcription factors, protein kinases, protein phosphatases, cytoskeletal proteins, signaling molecules, apoptosis - related proteins, as well as other types of proteins [32], while activated AKT modulates the function of numerous substrates involved in the regulation of cell survival, cell cycle progression and cellular growth [33, 34], whereas JNK acts as pro-apoptotic as well as anti-apoptotic depending on the conditions [35].

The cell cycle progression of eukaryotic cells is well controlled by cyclin, cyclin - dependent kinases (cdk), and cdk inhibitors.

Altieri and his team are currently focused on three programs to understand the biology of survivin with respect to cell cycle progression, in particular, mitosis, cell survival and the cellular stress response and how exploiting these pathways may provide new cancer therapeutics.

Validation of a cell cycle progression score for five - year mortality risk in patients with stage I lung adenocarcinoma.

Tumour cells are «glutamine - addicted» [1,2] because glutamine is coupled to mechanistic target of rapamycin (mTOR) signalling, which integrates signals from growth factors, energy status and amino acid nutrition and co-ordinates these signals with cell growth, cell cycle progression and antioxidant machinery [3].

CBX2 overexpression in breast tumors was associated with the upregulation of genes involved in cell cycle progression and is associated with poorer 5 - year survival.

Labeling, detection and quantification of cells in the S - phase (DNA synthesis) of cell cycle progression are crucial in characterizing the cellular responses to various treatments and genetic modifications.