Sentences with phrase «cell cycle proteins»

Expression of hypoxia - inducible factor - 1alpha and cell cycle proteins in invasive breast cancer are estrogen receptor related

Topics spanned the entire field of cancer research, from molecular studies of cell cycle proteins to the role of vegetable consumption in cancer prevention.

Cell cycle protein expression and proliferative status in human corneal cells.

Not exact matches

In this special section of Science, expert contributors retrace the long and tortuous path leading to the mapping and identification of the BRCA1 gene; discuss the ways in which BRCA mutation status has been integrated into the clinical management of patients in high - risk families; and highlight the role of the BRCA proteins in preserving the structural and numerical integrity of chromosomes throughout the cell cycle, a function that may explain their tumor suppressor activity.

PAK proteins allow melanoma to thrive through their action on a few different pathways, both encouraging cell cycle progression and inhibiting apoptosis, a form of cell death, the researchers found.

Ding's team took cells called fibroblasts from the connective tissues of mouse fetuses and bathed them in a cocktail of the four polyarginine - tagged proteins for 12 hours, then they removed the reprogramming proteins for 36 hours, and repeated this cycle four times over.

I had spent 4 years studying the interactions between two proteins involved in the cell cycle and DNA replication and repair.

The protein is now known to interact with and control dozens of different genes and proteins, and it helps regulate the cycle of molecular events by which cells grow and reproduce.

As a postdoc, she helped discover a key cell - cycle protein as part of a Nobel Prize — winning research team.

EPFL biologists and geneticists have uncovered how the circadian clock orchestrates the 24 - hour cycle of gene expression by regulating the structure of chromatin, the tightly wound DNA - protein complex of the cell.

He hopes to pursue projects such as developing therapeutics with chemists, working with biophysicists to study protein conformational changes relevant to viral entry into the cell, and investigating cellular trafficking pathways relevant to the viral life cycle in collaboration with cell biologists.

Cyclin D is synthesized during the first stage of cell replication and is believed to help drive the complex, multi-stage process, including interaction with the retinoblastoma (Rb) protein, whose function is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide.

These proteasomes usually rapidly stop functioning, leading to the accumulation of damaged proteins that further impair cell function, contributing to the vicious cycle that leads to cell death.

This study, published recently in PLOS Genetics, shows that in the particular case of meiotic cells such as spermatocytes, the signalling route of the ATM protein also participates in the control system of the cell cycle progression in response to DNA damage, something which until now was unknown.

In fact, the researchers showed that the synthesis of the capsule is controlled by the same mechanisms that regulate the cell cycle, and identified the protein that inhibits the production of the sugar capsule in one of the daughter cells.

In healthy human cells, the p53 protein helps prevent tumors by putting the brakes on the cell cycle to give an ailing cell time to fix itself — or die — rather than spawning more corrupted cells.

As Harbauer demonstrated, the cell cycle - dependent modification of the protein entry gate leads to an increased import of proteins.

When Corry and first author Wen Lu, a graduate student in immunology, sought to determine how the microRNA worked, they found histone deacetylase 4, a protein that plays a role in the regulation of DNA transcription, cell cycle and development.

The budding yeast, Saccharomyces cerevisiae, is a prime organism for studying fundamental cellular processes, with the functions of many proteins important in the cell cycle and signaling networks found in human biology having first been discovered in yeast.

In order to figure out which phase that chem7 actually acts upon, Ueda and her team used two fluorescent proteins of different colors to visualize the process of the cell cycles in the root of Arabidopsis thaliana.

These are other proteins that are periodically formed and again broken down during the various phases of the cell cycle.

The study has benefitted from the participation of CNIO researchers Marcos Malumbres and Ignacio Pérez de Castro, who are experts on protein AURKA and its role in the cell cycle.

«Our study found that by introducing an inhibitor of the STAT3 protein in repeated cycles, we could alternately replenish the pool of satellite cells and promote their differentiation into muscle fibers,» said Alessandra Sacco, Ph.D., assistant professor in the Development, Aging, and Regeneration Program at Sanford - Burnham.

Earlier this year, Kiyomitsu, working in Cheeseman's lab, saw that during the metaphase cell cycle step a dividing cell uses the motor protein dynein and two signals to perfectly align the cell's mitotic spindle structure in the middle of the cell.

Proteasomes play an important role in the degradation of proteins that regulate the cell cycle, thereby regulating cell growth.

It is a protein that has the ability to interrupt the cell cycle and block the division of diseased cells.

When expressed normally, the protein acts as an enzyme at the cell membrane, instigating a complex biochemical reaction that regulates the cell cycle and prevents cells from growing or dividing in an unregulated fashion.

One group of drugs — primarily targeting machinery involved in the cell cycle, protein chaperoning or DNA repair — elicited similar patterns of response across all cell lines.

«The CDK4 and 6 proteins are critical drivers of the cell - division cycle and are required for the formation and growth of various types of solid tumors,» says Dana - Farber's Shom Goel, MD, PhD, co-first author of the study with Molly DeCristo of the Hematology Division at BWH.

Emk is a serine / threonine protein kinase implicated in regulating polarity, cell cycle progression, and microtubule dynamics.

Paull and Whikehart [7] have also shown that p53 and TAp63 (a p53 family member) are relatively elevated in the normal central human corneal endothelium suggesting that these proteins inhibit cell - cycle promotion from the G1 to S phase.

Once freed, the proteasome degrades proteins required for cell cycle progression, thus driving cells into senescence.

Expression of cell cycle - associated proteins in human and rabbit corneal endothelium in situ.

[11] Since ABL activates a number of cell cycle - controlling proteins and enzymes, the result of the BCR - Abl fusion is to speed up cell division.

Proteasomal activity must be precisely regulated to direct cells through cell division, degrading the right proteins at the right time to help the cell progress to the next step in the division cycle.

In search of a mechanism behind the finding that HIV / gp120 reduced proliferation of aNPCs, the scientists studied the effect of the protein on the cell cycle.

Upregulated genes clustered into at least 7 functional groups, including immediate early genes or transcription factors, cell - cycle related genes, stress - responsive protein genes, cell signaling protein genes, cell adhesion and cell surface protein genes, genes involved in translation and protein turnover, and genes encoding metabolic proteins.

Furthermore; p16INK4a inhibits CDK4 and CDK6, and induces phosphorylation of the protein retinoblastoma (Rb) and liberating the transcription factor E2F which consequently result in cell cycle progression [29].

The neurosteroid allopregnanolone promotes proliferation of rodent and human neural progenitor cells and regulates cell - cycle gene and protein expression.

His group is are studying the mechanism of stable inherited epigenetic transcriptional repression by Polycomb - group (Pc - G) protein complexes, and the effects of deregulation of Pc - G genes on Homeobox gene expression, development, Cell cycle control and cancer formation.

Philipp Weissert (Tanaka, MPG)-- «Bmp proteins in urodele myotube cell cycle re - entry and in regeneration» (2008)

The function and dynamics of the apical scaffolding protein E3KARP are regulated by cell - cycle phosphorylation.

Hall and Rosbash then discovered a protein, named PER, that was made by the period gene, and figured out how it worked through a feedback mechanism — its own expression in the cell would cause PER to build up in the nucleus and would eventually effectively shut off the period gene, allowing it to cycle on and off on a daily schedule.

This cell cycle arrest in the G0 phase requires the retinoblastoma tumor suppressor protein (Rb).

The work has led him to explore the role of protein phosphorylation in a diverse array of cellular functions, including transformation, cell communication, cell adhesion, cell - cycle regulation, the control of gene expression, and protein degradation.

Jana Sontheimer (Pisabarro, TUD)-- «Functional characterization of proteins involved in cell cycle by structure - based computational methods» (2012)

To evaluate the molecular basis underlying cell cycle arrest after inhibition of mTOR, we assessed several cell cycle regulatory proteins after treatment with rapamycin or specific mTOR siRNA.

This contiguous set of protein - to - protein and protein - to - DNA interactions provided a direct explanation of how TGF -(beta) negatively controls the cell cycle.

Activated ERK1 / 2 modulates the functions of several transcription factors, protein kinases, protein phosphatases, cytoskeletal proteins, signaling molecules, apoptosis - related proteins, as well as other types of proteins [32], while activated AKT modulates the function of numerous substrates involved in the regulation of cell survival, cell cycle progression and cellular growth [33, 34], whereas JNK acts as pro-apoptotic as well as anti-apoptotic depending on the conditions [35].

The role of cell cycle checkpoint proteins is to integrate internal and external factors to determine whether the cell is prepared for progression of the cell cycle.