Sentences with phrase «cell cytosol»

LLO lacking the PEST - like sequence accumulated in the host - cell cytosol, suggesting that this sequence targets LLO for degradation.

Not exact matches

The mitochondria are located in the cytosol of the cells, outside of the cell nucleus; the cell's DNA genome is located inside the nuclear membrane.

The researchers found that when the cells were stressed, they quickly moved mRNAs from the endoplasmic reticulum to the cytosol.

Greber suspects that the nucleus has antiviral defense reactions, akin to the cytosol, and these defense reactions are variable between cells.

«Using this elegant method, we can reveal that not all the incoming viral DNA enters the cell nucleus as originally expected, but a significant fraction remains in the cytosol, the fluids of the cytoplasm,» explains Greber.

They then separated the cells into two groups — those containing mRNAs associated with ribosomes on the endoplasmic reticulum, and those containing mRNAs associated with free - floating ribosomes in the neighboring fluid - filled space known as the cytosol.

p53 activates a mitochondrial protease called Omi, which is then released into the cytosol of the cell when Ras causes mitochondria to fragment.

Against a background of nematode worms, this graphic depicts the stressed mitochondria (lower right, blue and red) accumulating lipid droplets (red balls) in the interior or cytosol of the cell.

«We were surprised to find that the cells we examined survived even after we had extracted most of their cytosol,» says ETH professor Vorholt.

The researchers were surprised to find that knockdown of one specific mitochondrial chaperone, mtHSP70, elicited a unique stress response mediated by fat accumulation, resulting in improved protein folding in the interior or cytosol of the cell.

In order to visualize this signal, the scientists performed experiments with transgenic Arabidopsis plants which were genetically modified to express a protein in the cytosol, the liquid inside the cells, which breaks down and releases light energy after it has bound calcium ions.

ATP is transported through further barrel pores across the mitochondrial outer membrane into the cytosol, which fuels life of human cells.

For proteins in the cytosol, the liquid inside the cell, these random molecular processes include differences in the break - down of proteins, or random partitioning into the two cells that form during cell division.

Mitochondria, also known as the cells» powerhouses, contain roughly 1,000 protein molecules that are transported from the cytosol.

Their preliminary findings indicate that MUS81 - induced movement of DNA to the cytosol also occurs in human cancer cells, including prostate cancer, breast cancer, colorectal cancer, uterine cancer, leukemia, and melanoma cells.

It had been thought that misfolded proteins spontaneously clump together in the cytosol, the fluid component of a cell's interior.

Time lapse images collected on a Zeiss Axiovert 200M fluorescence microscope in the core imaging facility of IGB allowed real - time monitoring of the redox state in the cytosol and mitochondria of live cells.

The recent development of genetically - encoded fluorescent biosensors specific to glutathione (GSH), the most abundant cellular redox buffer, has facilitated the IGB research group's discovery of distinct alterations of glutathione redox potentials in the cytosol versus mitochondria within the cell.

Taken together, these findings indicate different redox requirements for the glutathione thiol / disulfide redox couple within cytosol and mitochondria of resting cells and reveal distinct regulation of their redox poise in response to inhibition of glutathione biosynthesis.

Alcohol - treated HCV / Sod2 + / - mice also showed a greater concentration of FOXO3 in the cytosol of the cell compared to the nuclear location found in other types of mice.

Once the bacterial cell signaling protein cagA reaches the host cytosol, it is capable of altering subsequent generations of progenitor cells, leading to the development of cancer through changes in mitotic activity, apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial adhesion with gastric epithelial cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.

In guarding the cell against genetic damage, the p53 machinery functions both in the nucleus of the cell and in the cell's gel - like cytosol.

Bits of misfolded proteins processed by specialty organelles may accumulate in the main compartment of the cell, the cytosol, where they can be tagged for disposal by the cellular garbage service.

One essential virulence mechanism constitutes the specialized secretion systems that are designed to penetrate host - cell membranes and insert pathogen proteins directly into the host cell's cytosol.

Kriwacki also said that the paper was significant because it emphasizes the importance of the role that p53 plays in the cytosol of the cell, in addition to its role in the nucleus; his further studies are seeking to map that molecular machinery in great detail.

Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells.

These cells relied on a protein called cyclic GMP - AMP synthase (cGAS) to sense the viral DNA in the cytosol before the foreign DNA became integrated into the host genome.

Perforin - 2 protects host cells and mice by restricting the vacuole to cytosol transitioning of a bacterial pathogen.

DDX3 was strongly immunolocalized in the nucleus and less intensively in the cytosol of squamous cells in normal skin, but the nuclear staining was lost or dramatically decreased in cutaneous SCC.

TB bacteria can evade capture by phagolysomes, getting free in the cell's cytosol where a backup mechanism, autophagy, seeks again to deliver them to lysosomes.

In the Endocytic Trafficking and Intracellular Delivery team we study the cell biology of carbohydrate - binding proteins (lectins) at the level of cellular entry though clathrin - independent endocytosis, retrograde sorting on early endosomes, and translocation to the cytosol.

We study the cell biology of carbohydrate - binding proteins (lectins) at the level of cellular entry though endocytosis, retrograde sorting, and translocation to the cytosol.

The goal of the MTs is to do their work in the cytosol and keep the toxic metals away from the mitochondria and nucleus of the cell.

Life Extension Acetyl - L - Carnitine Arginate assists in maintaining cellular energy metabolism and transport of fatty acids from the cytosol into the mitochondria within the cell.

The pathway that results in the formation of 3 - hydroxy -3-methylglutaryl — CoA from acetyl CoA also occurs in the cytosol of hepatic cells where it is used instead for the biosynthesis of cholesterol.