Sentences with phrase «cell death pathways»

Likewise, unregulated growth, abnormal cell division, and defective cell death pathways are hallmark features of tumors.

We have identified the coral homologs of many of the key molecules that are involved in apoptotic and cell death pathways in higher organisms.

Hear how the rewiring of cell death pathways can sensitize cells to traditional chemotherapy agents.

«The virus evokes a response in the infected cell that activates a pre-programmed cell death pathway,» said Stanley Lemon, M.D., one of the study's authors and a professor of medicine at UNC's School of Medicine and UNC's Institute for Global Health & Infectious Diseases.

Scientists from the University of Helsinki, Finland have found that even a short - term shortage of ATP supply can be fatal for cancer cells because activation of a mitochondria - addressed cell death pathway.

«Immune 1 -2-3 punch against parasites reveals potentially ancient cell death pathway: «Microptosis,» which resembles programmed cell death in animal cells, could present an antimicrobial drug development opportunity.»

Kanneganti emphasized that their discoveries have fundamental importance, because they identify a key innate immune sensor that recognizes the influenza virus and a regulator of multiple cell death pathways.

Further experiments revealed that ZBP1 was, indeed, a «master assassin» in the cell, responsible for triggering three separate cell death pathways.

«Basically it is a mutation that makes potential stem cells, or precursor cells, susceptible to apoptotic cell death pathways.

«Same cell death pathway involved in three forms of blindness, study finds.»

Our research aims to continuously elucidate the caspase -2-mediated proinflammatory cell death pathway and its biological effect on microbial pathogenesis and protective immunity against brucellosis and other diseases.

«The TRAIL biochemical cell death pathway naturally lends itself as a drug target to restore anti-tumor immunity.»

Previous research from the Greene laboratory revealed that the main cause of cell death in HIV involves a programmed cell death pathway called pyroptosis, where the cells commit a particularly fiery form of suicide in self - defense to prevent the spread of the virus.

For example, if we had restricted our research to blood - derived cells, we would have missed primary cell death pathway operating during HIV infection.»

Using the techniques of protein chemistry, enzymology, crystallography, and recombinant DNA methodologies, we analyze the basic mechanism utilized by caspases to promote cell death pathways, and the mechanisms and specificity of the natural inhibitors that control them.

DOI: 10.4236 / abb.2012.326091 6,595 Downloads 10,607 Views Citations This article belongs to the Special Issue on Cell Death Pathways

Liver disease has been of central importance with aging and programmed cell death pathways.

Minocycline, a synthetic tetracycline - based antibiotic, has shown only limited success as an anti-cancer agent because it promotes the expression of pro-survival Bcl - 2 proteins and, subsequently, can lead to inhibition of caspase - 3 and caspase - 9 activation downstream in the cell death pathway.

What is the effect of the HIV - 2 accessory protein Vpx on HIV infectivity and the cell death pathway in lymphoid CD4 T cells?