Sentences with phrase «cell death receptors»

Not exact matches

Kite Pharma, one of the companies chasing a new generation of cancer drugs called chimeric antigen receptor T - cell (CAR - T) therapies, announced a patient death in a clinical trial of its experimental KTE - C19.

For some years now, a new class of drugs called antibody - drug conjugates (ADCs) have been used, which work in two ways: they consist of an antibody that binds selectively to the tumor cell receptor and interrupts the signal to propagate; they also act as a transport vehicle for a chemical substance that enters the cancer cells with the antibody and triggers their death.

IGFBP3 binds to a receptor protein on colonic stem cells causing their death and, in turn, damaging the intestinal lining.»

Akassoglou and her colleagues thought they had a good candidate in the gene for the p75 neurotrophin receptor (p75NTR), a regulator of cell death in the brain that also switches on soon after liver injuries.

PD - 1 (programmed cell death protein 1) is a receptor on the surface of T cells (the white blood cells that are part of the immune system), while PD - L1 (programmed death - ligand 1) is a molecule that binds to PD - 1 and is often over-expressed on the surface of cancer cells, enabling them to evade the immune system and allow cancer to grow and spread.

The Max Planck researchers then showed that less necroptosis of endothelial cells and less metastasis occur in genetically modified animals in which Death Receptor 6 is disabled.

The scientists also found that endothelial cells themselves give the signal for their own death: To do this, the vascular wall cells have a receptor molecule called Death Receptor 6 (DR6) on their surdeath: To do this, the vascular wall cells have a receptor molecule called Death Receptor 6 (DR6) on their receptor molecule called Death Receptor 6 (DR6) on their surDeath Receptor 6 (DR6) on their Receptor 6 (DR6) on their surface.

Under normal circumstances, cells must have some way of preventing the death domains of neighbouring receptors from coming together.

In the process, the plasma membrane receptor Fas (CD95) is key; this cell receptor occurs in almost all human cells and is involved in programmed cell death (apoptosis).

But the Israeli researchers have shown that the receptors can trigger cell death simply by binding to one another.

Across multiple triple - negative breast cancer subtypes, inhibiting the androgen receptor greatly increased apoptosis (programmed cell death), inhibited growth and increased necrosis by 60 percent in animal models.

Syndax Pharmaceuticals, Inc. («Syndax,» the «Company» or «we»)(Nasdaq: SNDX), a clinical stage biopharmaceutical company developing entinostat and SNDX - 6352 in multiple cancer indications, in collaboration with The Wistar Institute and Indiana University Melvin and Bren Simon Cancer Center, today announced the publication of a preclinical report demonstrating that entinostat, Syndax's oral, Class - I histone deacetylase inhibitor, enhances the antitumor effect of PD - 1 (programmed death receptor - 1) blockade through the inhibition of myeloid derived suppressor cells (MDSCs).

HIPK2 - Mediated Transcriptional Control of NMDA Receptor Subunit Expression Regulates Neuronal Survival and Cell Death

In cancer cells, IL - 13 binds to the receptor IL13Rα2 and, through a series of steps, prevents cancer cells from undergoing normal cell death.

To devise a potential new therapy, the investigators engineered a population of neural stem cells to express a potent version of a gene called TRAIL, which codes for a molecule that activates cell - death - inducing receptors found only on the surface of cancer cells.

PHILADELPHIA --(July 11, 2017)-- Researchers at The Wistar Institute, an international leader in biomedical research in the fields of cancer, immunology and infectious diseases, with collaborators at Indiana University Melvin and Bren Simon Cancer Center and Syndax Pharmaceuticals, Inc., (Nasdaq: SNDX) announce the results of a preclinical study demonstrating that entinostat, Syndax's oral, Class - I histone deacetylase inhibitor, enhances the antitumor effect of PD - 1 (programmed death receptor - 1) blockade through the inhibition of myeloid derived suppressor cells (MDSCs).

As an initial focus, researchers at Chicago will search for novel ways to take advantage of steroid hormones and their receptors to detect metastases, define their boundaries and deliver treatments directly to tumor cells in order to inhibit cell division or promote cell death.

Cardiac thromboxane A2 receptor activation does not directly induce cardiomyocyte hypertrophy but does cause cell death that is prevented with gentamicin and 2 - APB.

In prostate cancer cells the STAT3 - androgen receptor (AR) axis was inhibited by niclosamide and cell death in NSCLC was effected via c - JUN stress kinase and generation of ROS [39, 40].

Cell - surface galectin - 3 confers resistance to TRAIL by impeding trafficking of death receptors in metastatic colon adenocarcinoma cells.

The rationale for using CT - 011, an immunotherapy antibody that blocks the programmed death (PD)-1 receptor, is to boost the function of the immune system by inhibiting PD - 1 whose function, in part, is to inhibit T - cell response.

Glial cell line - derived neurotrophic factor (GDNF) was selected based on clear evidence that it increases neuronal sprouting, prevents cell death [20], [21] and has neuroprotective effects in the brain [11], [22]--[24], spinal cord [12] and retina [25]--[30], and because receptors for GDNF are expressed within mature retina [26], [31]--[34].

The Lauffenburger research group focuses on elucidating important aspects of receptor - mediated regulation of mammalian blood and tissue cell behavioral functions such as proliferation, adhesion, migration, differentiation, and death.

Response of Varicella Zoster specific T cells to Programmed Death Receptor - 1 blockade.

The halogens bromide, chloride, and fluoride compete with iodine for the receptor binding sites in the thyroid, but instead of activating the receptors they build up in thyroid tissue and cause thyroid cell death and inflammation.

The study found that curcumin is able to induce apoptosis (normal programmed cell death) in the most resistant breast cancer cells that lack estrogen receptors.