Sentences with phrase «cell death signaling»

From zero to sixty: cell death signaling in the city that never sleeps.

«We're excited to be contributing to a growing area of study of how astrocytes contribute to neurodegeneration, and to have uncovered a role for NO as a neuronal cell death signaling molecule,» said corresponding author Mel B. Feany, MD, PhD, a senior pathologist in the BWH Department of Pathology.

Not exact matches

When Hong further boosted MAPK signals and DNA damage in the tumor cells, she found that she could intensify tumor cell death.

For some years now, a new class of drugs called antibody - drug conjugates (ADCs) have been used, which work in two ways: they consist of an antibody that binds selectively to the tumor cell receptor and interrupts the signal to propagate; they also act as a transport vehicle for a chemical substance that enters the cancer cells with the antibody and triggers their death.

When this level was high enough, stress signals can lead to DNA damage and then trigger a form of cell death called parthanatos.

The exceptional cancer cells that escape the astrocytes do so by producing a protein called Serpin, which acts as a sort of antidote to the death signals fired at them by nearby astrocytes.

This suggests that «the python intestine may represent a valuable model for studying the interactions of metabolism with the regulation of cell division / death and WNT signaling relevant to cancer,» the researchers said.

The new chimera interferes with HER2 and HER3 signaling and ultimately leads to cancer cell death, as shown in the group's recent publication in Molecular Therapy: Nucleic Acids.

(In contrast, cancer cells fail to respond to the environmental signals that regulate cell death.

It can sense the presence of DNA damage, signal to other proteins that damage exists, aid in the repair of damage and stimulate cell death if the damage can not be repaired.

Both discoveries came from studies of mitochondria, the powerhouses of the cell that burn nutrients for energy but also play a key role in signaling, cell death and growth.

This has a positive effect initially, but as cell death progresses further, the correct signal may almost disappear.

It has long been known that cells tag proteins for degradation by labelling them with ubiquitin, a signal described as «the molecular kiss of death.»

The scientists also found that endothelial cells themselves give the signal for their own death: To do this, the vascular wall cells have a receptor molecule called Death Receptor 6 (DR6) on their surdeath: To do this, the vascular wall cells have a receptor molecule called Death Receptor 6 (DR6) on their surDeath Receptor 6 (DR6) on their surface.

The mechanism that becomes effective is a destructive signal sent by the antibody to the inside of the cancer cell and initiates its death.

The researchers studied the brains of people who died from HD and those who died of other, non-neurological diseases and identified a very specific genetic signal that strongly correlates disease severity and extent of neuronal, or brain cell death.

As described in Nature, pyroptosis ensues as immune cells rupture and release inflammatory signals that attract still more cells to repeat the death cycle.

In fact, researchers at Stanford are already collaborating on initial clinical trials of an antibody that blocks cancer cells from displaying one such death - evading signal — a molecule called CD47.

The team identified a critical pathway of molecular signals which throw a lifeline to cancer cells, enabling them to survive even though they contain vast DNA errors which would usually trigger cell death.

The researchers injured the mice retinas with a toxin that causes cell death in retinal ganglion cells and interneurons, another type of retinal cell whose job it is to transmit signals from photoreceptors to the brain.

Retinal cell death can be induced by phagocytic immune cells that infiltrate the tissue in response to injury or infection, but the molecular signals that trigger phagocyte invasion are largely unknown.

One aspect of their work studies how cell signaling pathways, such as those that initiate cell growth or death, are affected by the nanostructures and microstructures of implant materials such as titanium.

But what scientists did not know is how the mutations trigger a molecular signaling pathway that leads to the death of photoreceptor cells.

The team led by Rory Fisher, Ph.D., professor of pharmacology in the UI Carver College of Medicine, has identified a protein called RGS6 (regulator of G protein signaling 6) that acts through two separate mechanisms to control alcohol - seeking behavior and alcohol - induced cell death in heart, liver, and other organs.

The authors conclude that their six hallmarks — sustained proliferative signaling, evading growth suppression, resisting cell death, replicative immortality, induction of angiogenesis, and invasion / metastasis — continue to provide a useful conceptual framework for understanding the biology of cancer.

At the molecular level, he is discovering how mechanical forces signal gene expression to cause cell growth, migration and cell death.

Lactobacillus accelerates ISCs regeneration to protect the integrity of intestinal mucosa through activation of STAT3 signaling pathway induced by LPLs secretion of IL - 22 — Qihang Hou — Cell Death and Differentiation

Pro-apoptotic bax and bak control beta - cell death and early endoplasmic reticulum stress signalling.

We are identifying and characterizing the signaling molecules that control the interphase between cell survival and death cascades.

15:00 Paolo Pinton, Section of General Pathology, Department of Experimental and Diagnostic Medicine, Telethon Center for Cell Imaging and Interdisciplinary Center for the Study of Inflammation, University of Ferrara, Italy: «Mitochondrial Ca2 + signals: message of life and death.»

Insulin - like growth factor - I blocks Bcl - 2 interacting mediator of cell death (Bim) induction and intrinsic death signaling in cerebellar granule neurons.

Once inside, the virus's DNA acts as a danger signal that activates a protein called caspase 1, which can initiate cell death in several ways, including opening pores that disturb the cell's ion balance and releasing inflammatory signals that recruit other immune cells.

Our present studies are focusing on the molecular interactions which prevent excessive T cell death after the initial period of clonal expansion and which are essential for promoting late T cell division and providing long - term survival signals.

When Ras genes are mutated, cells grow uncontrollably and evade death signals.

Follin - Arbelet V, Torgersen ML, Naderi EH, Misund K, Sundan A, Blomhoff HK Death of multiple myeloma cells induced by cAMP - signaling involves downregulation of Mcl - 1 via the JAK / STAT pathway Cancer Lett (in press) PubMed 23454584

In glaucoma, EDN signaling increases in retinal cells before any damage occurs, and blocking it lessens cell death.

The King Lab has pioneered the use of selectin proteins to deliver apoptosis death signals to tumor cells in flowing blood, and to deliver therapeutic cargo (e.g., siRNA, chemotherapeutics) encapsulated in nanoscale liposomes.

The A. queenslandica genome allows us to assess systematically the origin of the six hallmarks of metazoan multicellularity: (1) regulated cell cycling and growth; (2) programmed cell death; (3) cell — cell and cell — matrix adhesion; (4) developmental signalling and gene regulation; (5) allorecognition and innate immunity; and (6) specialization of cell types.

Inhibition of Notch signaling reduces proliferation of stem cells, induces cell death, and down - regulates non-canonical Wnt5a, suggesting that the Notch pathway contributes to maintenance and motility of the stem cells.

This will lead to detailed new information about exactly what molecular signals are provoked and how they may contribute to cell death.

Tribbles normally binds and blocks the action of AKT, an insulin signaling protein directly involved in cell death and proliferation — and the tribbles genetic variants bound more strongly to AKT, thereby blocking proliferation and promoting cell death.

Interestingly, fluid shear stress also modulates how tumor cells respond to apoptosis death signals in the bloodstream.

By identifying, activating and inhibiting critical signaling nodes in cells, the scientists seek to better understand how these drive responses such as cell death and differentiation.

Calcitonin Gene - Related Peptide Enhances the Expression of Signaling Molecules of the Wnt 7b / Beta - Catenin Pathway in Rat Type II Alveolar Epithelial Cells Under Hyperoxia Hyperoxic lung injury is characterized by epithelial cell death and leukocyte infiltration / inflammation in the lung.

Read about the monitoring of apoptosis and necrosis in real time using the CLARIOstar's ACU feature, that maintains the appropriate O2 and CO2 environment for cells, while the RealTime - GloTM Annexin V Apoptosis and Necrosis Assay measures cell death using luminescence and fluorescent signals.

Cancer is known to develop through ten independent causative factors including DNA damage, chronic inflammation, cellular signaling dysfunction, abnormal cell death and metastasis.

One way that curcumin inhibits cancer is by restoring normal cell - death signalling in a cancerous cell.

Normal cell - death signalling is mediated by various cell proteins: some signal the cell to survive and some signal the cell to die.

Sometimes genes that are supposed to signal cell death at the appropriate time fail to turn on.