Sentences with phrase «cell depletion»

To test whether the childhood infection and stem cell depletion had any effect on the adult heart, the researchers exposed infected mice to two different types of cardiac stress.

Thus, the total effects of B - cell depletion on the immune system are likely to be complex and time - dependent.

Symptoms of anemia may be mild to life threatening depending on the degree of red blood cell depletion.

«This one - two punch of discoveries underscores the critical value of basic science — by uncovering the major cause of CD4 T cell depletion in AIDS, Dr. Greene's lab has been able to identify a potential new therapy for blocking the disease's progression and improving on current antiretroviral medications.»

However, no differences between the use of CD4ζ - modificed and unmodified cells were observed for HIV infection levels and CD4 T - cell levels, although the data does indicate that both NK cells populations can inhibit HIV replication and prevent CD4 + T - cell depletion in vivo.

Three gene expression signatures can help rheumatologists predict which patients are more likely to respond to tumor necrosis factor inhibitors (TNFi) or B - cell depletion therapies in patients with moderate to severe rheumatoid arthritis, according to new research findings presented this week at the 2016 ACR / ARHP Annual Meeting in Washington.

Serum BAFF and APRIL levels, T - lymphocyte subsets, and immunoglobulins after B - cell depletion using the monoclonal anti-CD20 antibody rituximab in myalgic encephalopathy / chronic fatigue syndrome.

Clinical impact of B - cell depletion with the anti-CD20 antibody rituximab in chronic fatigue syndrome: a preliminary case series.

These include T - cell depletion by apoptosis; anergy (ie, the process by which T cells that are presented with a peptide in the absence of costimulatory signals become refractory to further stimulation with the antigen and are therefore inactivated); and the development of regulatory T cells, which can actively suppress antigen - specific responses following re-challenge with the antigen.

Priority will be given to studies that evaluate combinations of agents that induce immune deviation and / or regulation, produce effector cell depletion or exhaustion, to achieve durable clinical remission of disease.

Mechanistically, CD8 + T cell depletion, IFN - γ neutralization, or implantation of tumors in IFN - γ receptor knockout mice abrogated the vessel perfusion enhancement and antitumor effects of ICB.

This may be one mechanism for lack of effect from B - cell depletion therapy [17].

That's because despite rapid B - cell depletion, improvement lagged.

Neither tocilizumab nor naïve T cell depletion has yet proved its worth in randomized studies, however.

The team's results hint that, at least in lymphoid tissues, cell - to - cell HIV transmission may be the main means of CD4 + T cell depletion.

Prf1 − / − mice develop lethal HLH secondary to CD8 T cell — mediated IFN - γ production, as CD8 T cell depletion or IFN - γ neutralization protect Prf1 − / − mice from disease.

«What our data show is that the major mechanism underlying CD4 + T cell depletion... requires cell - to cell transmission,» said study coauthor Warner Greene, an immunologist at the Gladstone Institute of Virology and Immunology and the University of California, San Francisco.

«What is really driving HIV pathogenesis is the combination of CD4 + T - cell depletion and inflammation,» Greene said.

T cell depletion and purification were performed with anti - CD 90.2 MicroBeads and a CD25 isolation kit (Miltenyi Biotec), according to the manufacturer's protocols.

Our pilot case series [4] suggested that B - cell depletion was associated with clinical improvement in CFS patients.

To establish that the IL - 15 superagonist's effect on HIV - infected cells is acting primarily through NK cells, the authors performed a cell depletion study: prior to intrasplenic injection, the hu - PBMCs were depleted of either NK cells or CD8 + T cells.