Sentences with phrase «cell depletion in»

However, no differences between the use of CD4ζ - modificed and unmodified cells were observed for HIV infection levels and CD4 T - cell levels, although the data does indicate that both NK cells populations can inhibit HIV replication and prevent CD4 + T - cell depletion in vivo.

«This one - two punch of discoveries underscores the critical value of basic science — by uncovering the major cause of CD4 T cell depletion in AIDS, Dr. Greene's lab has been able to identify a potential new therapy for blocking the disease's progression and improving on current antiretroviral medications.»

Not exact matches

Specifically, when capsaicin frequently binds to receptors within the human central nervous system's TRPV1 channel (the sensory receptor system for pain and heat detection), these receptors deplete and this depletion results in a whole host of benefits for the central nervous system at large, including terminating cancer cells, increasing the metabolic rate and digestive efficiency, increasing circulatory blood flow, and combatting inflammation, and making you feel better about the world.

CEP63 depletion increases stem cell death in the developing mouse brain.

The brains of the human babies with CHD that died in the first month of life also showed a depletion of neural precursor cells in the SVZ.

This, as with RORγt - deficient mice, selective deletion of MHCII in ILCs resulted in hyperactive T - cell responses directed against commensal bacteria and systemic inflammatory responses, all of which could be alleviated by depletion of commensal bacteria with broad - spectrum antibiotics.

Depletion of five SSUP proteins (Imp4, Mpp10 / Mphosph10, Wdr36, Wdr46, and Wdr75) resulted in a reduction of Nanog expression, and the absence of one SSUP component (Cirh1a) caused cell death.

Researchers found the gene therapy approach had stronger results when used in combination with either depletion of immunosuppressive cells from the tumor mass or with immune checkpoint blockade.

Neither tocilizumab nor naïve T cell depletion has yet proved its worth in randomized studies, however.

In SA2 - deficient Ewing sarcoma and bladder cancer, further depletion of SA1 profoundly and specifically suppressed cancer cell proliferation, survival and tumorigenic potential.

Additional experiments showed that genetic disruption of MrcA, depletion of ITPR3, and depletion of STIM1 all significantly inhibited extrusion in infected cells, as did chemical disruption of calcium ion signaling.

Mechanistically, CD8 + T cell depletion, IFN - γ neutralization, or implantation of tumors in IFN - γ receptor knockout mice abrogated the vessel perfusion enhancement and antitumor effects of ICB.

Clinical impact of B - cell depletion with the anti-CD20 antibody rituximab in chronic fatigue syndrome: a preliminary case series.

Eiichi Nakayama and Akiko Uenaka report in vivo depletion of CD8 T cells by administrating an anti-Lyt antibody.

AGEs impair this axonal transport and alpha adrenergic blockers (acting on cell «stress receptors») can exert a protection of this phenomenon.Thus, will look on the molecular mechanisms of this process (crosslinking of motor proteins in axonal transport, energy depletion etc.) by analyzing the colocalization of fluorescence staining of (motor --RRB- proteins and tagged AGE - molecules and by methods of molecular biology.

However, the constant presence of HIV in the body, even at very low levels, causes the immune system to remain activated continuously, leading to long - term inflammation and depletion of T cells that help the body fight infection.

Roberts, E. W. and Deonarine, A. and Jones, J. O. and Denton, A. E. and Feig, C. and Lyons, S. K. and Espeli, M. and Kraman, M. and McKenna, B. and Wells, R. J. B. and Zhao, Q. and Caballero, O. L. and Larder, R. and Coll, A. P. and O'Rahilly, S. and Brindle, K. M. and Teichmann, S. A. and Tuveson, D. A. and Fearon, D. T. (2013) Depletion of stromal cells expressing fibroblast activation protein - alpha from skeletal muscle and bone marrow results in cachexia and anemia.

To determine the causes of this depletion, the investigators treated neurons grown in cell culture with amyloid - beta proteins, which accumulate in Alzheimer brains.

The reasons include: depletion of the messenger molecule nitric oxide, lysis of red blood cells and alterations in the remaining cellsâ $ ™ stiffness.

These include T - cell depletion by apoptosis; anergy (ie, the process by which T cells that are presented with a peptide in the absence of costimulatory signals become refractory to further stimulation with the antigen and are therefore inactivated); and the development of regulatory T cells, which can actively suppress antigen - specific responses following re-challenge with the antigen.

Tryptophan depletion results in the inhibition of effector T cells and kynurenine accumulation results in the expansion of immune - suppressant regulatory T cells.

Natsume, Toyoaki, et al. «Rapid Protein Depletion in Human Cells by Auxin - Inducible Degron Tagging with Short Homology Donors.»

We found that depletion of ABL kinases in breast cancer cells decreased STAT5A mRNA expression (Fig. 6D) without decreasing total STAT5 protein abundance as measured by Western blotting with antibodies that detect both STAT5A and STAT5B (Fig. 7D and fig.

In addition to inhibiting STAT5 signaling, we found that depletion of ABL kinases decreased the expression of the Hippo pathway mediator TAZ and downstream target genes in triple - negative and HER2 + breast cancer cellIn addition to inhibiting STAT5 signaling, we found that depletion of ABL kinases decreased the expression of the Hippo pathway mediator TAZ and downstream target genes in triple - negative and HER2 + breast cancer cellin triple - negative and HER2 + breast cancer cells.

Dr. Rubin further showed that a depletion of SMN in satellite cells prevents regeneration after the muscle has been damaged.

Moreover, we found that treatment with a selective allosteric inhibitor of the ABL kinases or simultaneous depletion of both ABL kinases in breast cancer cells impaired breast cancer bone metastases and decreased osteoclast activation in vitro and osteolysis in vivo.

Characteristic neuropathological findings were focal depletion of diffuse and neuritic plaques, but not of amyloid angiopathy, and the presence of small numbers of extremely dense (collapsed) plaques surrounded by active microglia, and multinucleated giant cells filled with dense Abeta42 and Abeta40, in addition to severe small cerebral blood vessel disease and multiple cortical hemorrhages.

Expression of a constitutively active STAT5A mutant (STAT5A *) reversed the reduction in MMP1, IL - 6, and TNC abundance induced by depletion of both ABL kinases in breast cancer cells (Fig. 7, E and F, and fig.

He presented results from both SMA mouse models and patients that demonstrated SMN depletion results in muscle - intrinsic defects such as reduced satellite cell number, a delay in the myogenic program, reduced myoblast fusion, and molecular homeostasis disruption.

Depletion of ABL kinases does not affect YAP1 protein abundance, localization, or tyrosine phosphorylation in breast cancer cells.

Depletion of ABL kinases in breast cancer cells also decreased the abundance of MMP1, a protease that cleaves fibrillar collagens and promotes the proteolytic release of bound growth factors (32).

Our pilot case series [4] suggested that B - cell depletion was associated with clinical improvement in CFS patients.

Depletion of ABL kinases in breast cancer cells decreased IL - 6 concentrations and was accompanied by increased OPG expression in osteoblasts.

In the majority of cultured mammalian cells, nutrient depletion induces autophagy within minutes, with maximal levels observed when cells are cultured in the simultaneous absence of nutrients and growth factors [128In the majority of cultured mammalian cells, nutrient depletion induces autophagy within minutes, with maximal levels observed when cells are cultured in the simultaneous absence of nutrients and growth factors [128in the simultaneous absence of nutrients and growth factors [128].

In addition, the depletion of Tregs from donor T cells did not have an adverse influence on the effect of VPA.

«These results highlight how a natural cellular defense normally used by the host to repel foreign invaders goes awry in HIV infection, resulting in a profound depletion of CD4 T cells.

8) Korinek, V., Barker, N., Moerer, P., van Donselaar, E., Huls, G., Peters, P.J. and Clevers, H. Depletion of epithelial stem - cell compartments in the small intestine of mice lacking Tcf - 4.

In the JBC article, Lipschutz and his MUSC coauthors go a step further — showing in cell culture and a zebrafish model that depletion of Tuba, a guanine nucleotide exchange factor required for Cdc42 activation, also disrupts renal ciliogenesiIn the JBC article, Lipschutz and his MUSC coauthors go a step further — showing in cell culture and a zebrafish model that depletion of Tuba, a guanine nucleotide exchange factor required for Cdc42 activation, also disrupts renal ciliogenesiin cell culture and a zebrafish model that depletion of Tuba, a guanine nucleotide exchange factor required for Cdc42 activation, also disrupts renal ciliogenesis.

Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases.

The aim of WICT is the removal from the organismal environment of accumulated cellular and intracellular damage present in the patient's endogenous cells, including telomere depletion, nuclear DNA damage and mutations, mitochondrial DNA damage and mutations, replicative senescence, functionally - deleterious age - related changes in gene expression and accumulated cellular and intracellular aggregates.

To understand the mechanism (s) underlying the MELK function in BBC cells, we examined how inducible shRNA - mediated MELK depletion affects various cellular processes.

A study published in the British Journal of Nutrition in 2008 found that 198 subjects who followed a strict raw food diet lacked antioxidant lycopene — a red pigment found in tomatoes and proven to protect cells from free radicals and fight collagen depletion, heart disease and skin cancer.

The main reason is within its ability to take on the role of the main molecule for energy storage and being able to quickly reverse the process of energy depletion in your muscle cells while you are exercising.

Magnesium is mitogenic (causes cell division) in osteoblasts (the major cellular component of bone) and magnesium depletion inhibits cellular growth.

We tend to get more mineral depletion in our cells and a big, big part of that is due to a high amount of electromagnetic field that is all around us now, with computers and smart phones, etc, that essentially increases the leakiness of cells.

In mammalian cells, total depletion of amino acids is a strong signal for autophagy, but the role of individual amino acids is more variable.

DNA damage has been shown to cause cancer and lead to depletion of stem cell pools + it also plays a role in the aging process.

Massive sugar addiction can result in obesity, diabetes, heart damage or failure, cancer cell production, depletion of brain power, and shorter lifespans.1

Tap water, prescription drugs, chemicals, environmental pollutants, personal care products, processed food, food additives, electromagnetic radiation (EMR from cell phones, cordless phones, microwaves and computers) and mineral depletion of the soil in which our food is grown are all saboteurs of good health.

Muscle cells ordinarily contain significant levels of glutathione, and its depletion leads to mitochondrial damage.23 Patients undergoing surgical trauma have been found to exhibit reduced glutathione levels in their skeletal muscles.21 It is tempting to speculate that cholesterol sulfate provides the sulfur needed for glutathione synthesis, so that the deficiency would be explained by the reduced availability of cholesterol following the immune system's heightened response to surgical trauma.