Sentences with phrase «cell depletion with»

Clinical impact of B - cell depletion with the anti-CD20 antibody rituximab in chronic fatigue syndrome: a preliminary case series.

Not exact matches

The brains of the human babies with CHD that died in the first month of life also showed a depletion of neural precursor cells in the SVZ.

This, as with RORγt - deficient mice, selective deletion of MHCII in ILCs resulted in hyperactive T - cell responses directed against commensal bacteria and systemic inflammatory responses, all of which could be alleviated by depletion of commensal bacteria with broad - spectrum antibiotics.

Researchers found the gene therapy approach had stronger results when used in combination with either depletion of immunosuppressive cells from the tumor mass or with immune checkpoint blockade.

To determine the causes of this depletion, the investigators treated neurons grown in cell culture with amyloid - beta proteins, which accumulate in Alzheimer brains.

These include T - cell depletion by apoptosis; anergy (ie, the process by which T cells that are presented with a peptide in the absence of costimulatory signals become refractory to further stimulation with the antigen and are therefore inactivated); and the development of regulatory T cells, which can actively suppress antigen - specific responses following re-challenge with the antigen.

Natsume, Toyoaki, et al. «Rapid Protein Depletion in Human Cells by Auxin - Inducible Degron Tagging with Short Homology Donors.»

We found that depletion of ABL kinases in breast cancer cells decreased STAT5A mRNA expression (Fig. 6D) without decreasing total STAT5 protein abundance as measured by Western blotting with antibodies that detect both STAT5A and STAT5B (Fig. 7D and fig.

Moreover, we found that treatment with a selective allosteric inhibitor of the ABL kinases or simultaneous depletion of both ABL kinases in breast cancer cells impaired breast cancer bone metastases and decreased osteoclast activation in vitro and osteolysis in vivo.

Characteristic neuropathological findings were focal depletion of diffuse and neuritic plaques, but not of amyloid angiopathy, and the presence of small numbers of extremely dense (collapsed) plaques surrounded by active microglia, and multinucleated giant cells filled with dense Abeta42 and Abeta40, in addition to severe small cerebral blood vessel disease and multiple cortical hemorrhages.

Our pilot case series [4] suggested that B - cell depletion was associated with clinical improvement in CFS patients.

In the majority of cultured mammalian cells, nutrient depletion induces autophagy within minutes, with maximal levels observed when cells are cultured in the simultaneous absence of nutrients and growth factors [128].

They identified a depletion of TDP - 43 from the cell nuclei before any signs of neurodegeneration occurred, signifying that this loss may be a direct cause of the cell death associated with FTD.

We tend to get more mineral depletion in our cells and a big, big part of that is due to a high amount of electromagnetic field that is all around us now, with computers and smart phones, etc, that essentially increases the leakiness of cells.

Instead, the feeling is conveyed even more accurately in less time with a succession of quick shots of cab rides, train bench waits, and cell phone battery depletion.

It is often this septicemia, combined with the effects of dehydration and the depletion of white blood cells needed to fight the infection, which proves fatal to most cats infected with Panleuk.