Sentences with phrase «cell development at»

Among the three 96 - well plates studied, 72 wells satisfied our selection criteria (see Materials and Methods) and were followed up on the cell development at the clonal level (Fig. 1B).

Our side by side analysis uncovers the dynamics of epigenetic programming occurring in germ cell development at single base resolution in human and mouse cells.»

Changes in cellular metabolites have been shown to regulate embryonic stem cell development at the earliest stages of life.

«We are very encouraged by the simplicity of our finding,» says Juan Domínguez - Bendala, director of stem cell development at the Diabetes Research Institute in Miami, Florida.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

The company's CAR T - cell cancer immunotherapy furthest in development at present is JCAR017.

Our home cell system is a funtional structure which has helped with building stronger relationships and works well among the yout who are highly relational at this stage of their human development, but I still feel we are missing it somewhere.

Nanog is said to act at a later stage of development to keep cells in an undifferentiated state.

Nanog appears in both the morula (12 - cell stage) and in high concentration at an advanced stage of normal embryonic development, the blastocyst (150 - cell stage).

The difficulties associated with obtaining nerve tissue at the correct stage of development and differentiation from aborted embryos means that foetal tissue transplantation is no longer in favour, but the creation of human embryos specifically as sources of stem cells, and the push to use «spare» embryos from IVF treatments is gatheringmomentum.

The first page of Larsen's Human Embryology states that, `... [W] e begin our description of the developing human with the formation and differentiation of the male and female sex cells or gametes [sperm and egg], which will unite at fertilisation to initiate the embryonic development of a new individual».

According to Mashable, Calico will specialize in new research and developments that can cause the human body's cells to wear - down at a much slower pace.

Incredible Brain Development At birth a baby's brain contains 100 billion nerve cells (or neurons), all she will ever have, but not the programming of those cells.

But researchers at UC Irvine recently revealed how DHA deficiency during pregnancy limits baby brain development — without enough DHA, brain cells aren't able to grow and form connections.

Stem cells play an important role in the development of many organs, and the loss of these cells at birth could affect babies» later development, the researchers write.

This happens at the very earliest stage of development, when the zygote is no more than a cluster of a few cells.

Researchers are looking at delays or abnormalities in brain development of nerve cells that are responsible for heart and lung function.

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However, the prime minister stressed the public at large must understand and accept new scientific developments such as the MMR vaccination, stem cell research and GM foods.

Scientists at the Johns Hopkins Kimmel Cancer Center say they have preliminary evidence in laboratory - grown, human airway cells that a condensed form of cigarette smoke triggers so - called «epigenetic» changes in the cells consistent with the earliest steps toward lung cancer development.

After 2 years as a resident at the University of Chicago Hospitals, Sargis went to work with Matthew Brady, an endocrinologist in the University of Chicago's Pritzker School of Medicine, studying the development of adipocytes, the cells that store fat.

A research team at the University of California, Riverside has discovered a way for chemotherapy drug paclitaxel to target migrating, or circulating, cancer cells, which are responsible for the development of tumor metastases.

At an early stage of development, the miniature organs grown from autistic patients» stem cells also showed faster cell division rates than those grown from the cells of non-autistic relatives.

at The Scripps Research Institute and the Burnham Institute, and also at the National Institutes of Health, where her studies spanned signal transduction, cell migration, and neuronal development.

«There was this initial thought that [circulating tumor cells] are only present at late stage,» says Sollier - Christen, but she notes that in the past year, several studies using more sensitive techniques have found such cells much earlier in tumor development, even before the tumor becomes visible by conventional imaging techniques.

Now, a collaborative team of scientists at Washington University in St. Louis has developed a new process to generate NP - like cells from hiPSCs, one that truly goes back to the beginning and mimics the process of embryonic development.

«What's really exciting about this was that the activity differences were detected at a critical time in brain development: when neural progenitor cells are proliferating and expanding in number, just prior to producing neurons,» Silver said.

In a groundbreaking study that provides scientists with a critical new understanding of stem cell development and its role in disease, UCLA researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research led by Dr. Kathrin Plath, professor of biological chemistry, have established a first - of - its - kind methodology that defines the unique stages by which specialized cells are reprogrammed into stem cells that resemble those found in the embcell development and its role in disease, UCLA researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research led by Dr. Kathrin Plath, professor of biological chemistry, have established a first - of - its - kind methodology that defines the unique stages by which specialized cells are reprogrammed into stem cells that resemble those found in the embCell Research led by Dr. Kathrin Plath, professor of biological chemistry, have established a first - of - its - kind methodology that defines the unique stages by which specialized cells are reprogrammed into stem cells that resemble those found in the embryo.

Lewis is now skimming through these genes to check their function; of those he's looked at so far, several are involved in growth and development, cell differentiation, cell death, and protecting against cancer.

Working with Skeletal Biologists at Southampton General Hospital, Catarina is investigating new optical techniques to monitor the development of the cells, used in new regenerative medicine approaches — in this case, to create and grow cartilage from human stem cells.

The enzyme at the center of this study, ADAR1, is normally expressed during fetal development to help blood cells form.

Scientists at the Rosalind Franklin University of Medicine and Science in Chicago found a «remarkable similarity» between the cells that support the growth and development in placentas and in tumors.

Since pseudouridine modifications may affect various RNA molecules in different types of normal and malignant cells, «our discoveries pave the way for future avenues of research aimed at exploring the role of pseudouridine in human development disease,» concludes Cristian Bellodi.

In the ovary of a normal mouse (left), a large follicle is shown at a late stage of development (a light pink oocyte surrounded by follicular cells, inset).

Researchers at the University of Memphis and University of Pennsylvania report the development of robust new liver and fat cell models that report circadian clock function.

However, Stephen Back, a neurologist at the Oregon Health and Science University in Portland, points out that there is not yet proof that myelin - producing cells are stuck in arrested development in infants with brain injuries, although this has been shown both in mice and in adults with multiple sclerosis.

«I do not see any full development of major parts of the brain,» agrees Elena Cattaneo, who directs the Centre for Stem Cell Research at the University of Milan in Italy.

In the second Cell paper, researchers collaborated with scientists at the University of Cambridge, McGill University in Canada and several UK and European institutions to explore the role that epigenetics plays in the development and function of three major human immune cell types: CD14 + monocytes, CD16 + neutrophils and naïve CD4 + T cells, from the genomes of 197 individuCell paper, researchers collaborated with scientists at the University of Cambridge, McGill University in Canada and several UK and European institutions to explore the role that epigenetics plays in the development and function of three major human immune cell types: CD14 + monocytes, CD16 + neutrophils and naïve CD4 + T cells, from the genomes of 197 individucell types: CD14 + monocytes, CD16 + neutrophils and naïve CD4 + T cells, from the genomes of 197 individuals.

Some of the researchers at the centre will study the differentiation of stem cells into other cell types, one group by using human embryonic stem cell biology and another by studying early embryo development.

«Our cells may provide a substantial opportunity for the development of zero - emission vehicles with a driving range similar to that of gasoline vehicles,» says Elton Cairns, of the Environmental Energy Technologies Division (EETD) at Berkeley Lab.

An experimental drug in early development for aggressive brain tumors can cross the blood - brain tumor barrier, kill tumor cells and block the growth of tumor blood vessels, according to a study led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).

We believe that they will also lead to the development of a whole new range of therapies for neurodegenerative diseases of the central nervous system,» explains corresponding author of the study Jihwan Song, professor and director of Neural Regeneration and Therapy Group at the CHA Stem Cell Institute of CHA University.

But exposure to the chemicals blocked cell division, which could lead to neurological disabilities in babies if their cells are exposed at particular times during fetal development.

Carbon capture is an obvious extended use for fuel cells, said Tony Leo, vice president of application engineering and advanced technology development at FuelCell Energy.

The Lund University research team has looked at how cancer cells communicate with surrounding cells and how this encourages the development of malignant tumours.

Current supported funding areas at NINDS and NIMH include counterterrorism and neuroscience research, neural prosthesis program, neural stem cells, adult and pediatric translational research and treatment development, and the NIH neuroscience Blueprint.

Today's findings augment recent research also published in Nature (Dec. 7, 2016) detailing the team's development of a «stemness biomarker» — a 17 - gene signature derived from leukemia stem cells that can predict at diagnosis which AML patients will respond to standard treatment.

This allows us to reveal how drugs affect heart functions in a scenario where the two cell populations are closely coupled,» said Ben Maoz, Ph.D., a co-first author on the second study, who also is a Technology Development Fellow at the Wyss Institute and a member of Parker's group.

«If we can preserve these important cells, we may be able to decrease the negative impacts of traumatic brain injury,» said first author David Cantu, Ph.D., a postdoctoral scholar at Tufts University School of Medicine, and member of the NIH - funded Institutional Research Career and Academic Development Awards (IRACDA) Program, Training in Education and Critical Research Skills (TEACRS), at the Sackler School of Graduate Biomedical Sciences at Tufts.

«Recent studies suggest that epigenetic modifications may contribute to the development of cancer progenitor cells that can induce drug resistance and the relapse of different types of cancer,» said Sibaji Sarkar, PhD, instructor of medicine at BUSM.