Sentences with phrase «cell differentiation in»

Moreover, ES cell differentiation in vitro recapitulates events that take place during early embryonic development including the formation of the three germ layers of ectoderm, mesoderm and endoderm, and the emergence of endothelial, hematopoietic, cardiac, neuronal and hepatic or pancreatic cells [8], [9].

VASA was detected earlier in cells cultured in testicular cell - conditioned medium than in those cultured in non-conditioned medium or in ovarian cell - conditioned medium, suggesting that the initiation of germ cell differentiation in testicular cell - conditioned medium was faster than that in ovarian cell - conditioned medium.

The effects of extrinsic factors was examined using gonadal conditioned media or several growth factors for germ cell differentiation in vitro in monkeys.

Di Pietro C, De Giorgi L, Cosorich I, Sorini C, Fedeli M and Falcone M. miRNA - 133b regulation of Th - POK expression and dendritic cell signals affect NKT17 cell differentiation in the thymus.

It is unclear whether components of the culture medium other than extrinsic factors affect germ cell differentiation in vitro in monkeys.

A future aspect of our mouse work is directed towards use of ES cell differentiation in culture as a model for epigenetic decisions and stem cell manipulations.

Contribution of Xanthine Oxidoreductase to Mammary Epithelial and Breast Cancer Cell Differentiation In Part Modulates Inhibitor of Differentiation - 1.

«This new understanding of the role played by scrawny may make it easier to expand stem cell populations in culture, and to direct stem cell differentiation in desired directions,» says Spradling.

Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4.

«We saw better germ - cell differentiation in this transplantation model than we've ever seen,» said Renee Reijo Pera, PhD, former director of Stanford's Center for Human Embryonic Stem Cell Research and Education.

This is the first time we've observed how matrix stress relaxation impacts stem cell differentiation in 3D.»

They also are key to cell differentiation in developing organisms, but the mechanisms are not fully understood.

Not exact matches

If you really want to know more about development and differentiation of cells and tissue... do some reading, it's pretty straight forward stuff that is well described in the literature.

The difficulties associated with obtaining nerve tissue at the correct stage of development and differentiation from aborted embryos means that foetal tissue transplantation is no longer in favour, but the creation of human embryos specifically as sources of stem cells, and the push to use «spare» embryos from IVF treatments is gatheringmomentum.

As differentiation continues, various genes are «switched off» but stem cells, even in adults, retain a certain pluripotency in order to produce fully differentiated cells lost by damage or ageing.

Kauffman was trained as a physician, but gave up medical practice to study fundamental questions in biology: «I entered biology because the magnificent wonder of cell differentiation overwhelmed me» (HU94).

Such embryo research might teach us more about cell differentiation and early embryo development, it might make possible greater success in bone marrow transplants, and it might help us to treat more successfully degenerative diseases and spinal cord injuries.

Stem cells have also been identified in human milk, and have the potential to differentiate into mammary epithelial lineages under mammary differentiation conditions in vitro, as well as other cell types in corresponding microenvironments, including bone cells, brain cells, liver cells, pancreatic beta cells and heart cells.

In the first half of pregnancy secretory differentiation (the differentiation of alveolar epithelial cells into milk - secreting cells), ductal branching and lobular formation of the breast (mammogenesis) occur.

All the interdisciplinary skills and knowledge he had gathered during his scientific training — which had covered biochemistry, biotechnology, biomaterials, and stem cell biology — put him «in a very advantageous position to address this question» of how to develop nanoparticles that could modulate stem cell differentiation on demand, he says.

Furthermore, by making use of embryonic stem cells and in vitro differentiation, SIF - seq can be used to assess enhancer activity in a wide variety of disease - relevant cell types.»

Not only did treatment with the AA147 compound activate ATF6 in stem cells, it altered the cells» differentiation path.

The study also found that in addition to its role in determining the sex of somatic cells, Sxl regulation by m6A is required to initiate germline stem cell differentiation for developing eggs.

We examined the function of this structural differentiation by determining how cell ensembles in rat CA3 and CA1 generate representations of rooms with common spatial elements.

By analysing the early steps that precede tumor formation, Alexandra Van Keymeulen and colleagues found that expression of oncogenic Pik3ca reactivates a multilineage differentiation program in adult stem cells that resembles to an immature embryonic state.

Lewis is now skimming through these genes to check their function; of those he's looked at so far, several are involved in growth and development, cell differentiation, cell death, and protecting against cancer.

The research team, led by bioengineering professor Adam Engler, also found that a protein binding the stem cell to the hydrogel is not a factor in the differentiation of the stem cell as previously suggested.

The genes we detect are involved in the regulation of cell development, and are specifically important in synapse formation, axon guidance and neuronal differentiation.

After deciphering this natural differentiation process, the investigators duplicated it in the laboratory dish by adding a sequence of proteins, called growth factors, to the fluid bathing the stem cells.

Drosha degrades the messenger RNA for NFIB in the adult hippocampal stem cells and prevents the expression of this transcription factor which is necessary for the differentiation of oligodendrocytes and thus blocks their development and therefore biases differentiation towards neurons.

Now, in a new study published today, Sept. 8, in the Proceedings of the National Academy of Sciences, a team of researchers from the University of Wisconsin - Madison has added a new wrinkle to the cell differentiation equation, showing that the stiffness of the surfaces on which stem cells are grown can exert a profound influence on cell fate.

«We're only giving them one cue out of dozens that are important in stem cell differentiation,» said Engler.

This explains why such DNA modifications play a major role in the differentiation of stem cells.

[Praveen R. Arany et al, Photoactivation of Endogenous Latent Transforming Growth Factor — β1 Directs Dental Stem Cell Differentiation for Regeneration] Could a light - based treatment for cavities and chipped teeth eventually be in the offing for people?

Now a team of researchers has been able to identify accurately the sentinel node (SN) in head and neck squamous cell carcinoma (HNSCC) using a novel tracer; a challenging task because there are up to 150 different lymph nodes in the neck, and the differentiation of true SNs from secondary nodes is difficult.

Their analysis of more than 4,000 individual tumor cells, the largest effort to date in brain tumors, finds three developmental categories of cancer cells — one resembling neural stem cells and two characterized by sets of genes indicting paths towards differentiation.

Scientists know that different auxin concentrations in cells and their environment assume a key role in these differentiation processes.

They cross the blood - brain / blood - tumor barrier, and accumulate within brain tumor sites, where they target oncogenes, regulate cell growth and differentiation, reduce tumor burden and prolong survival in our mouse models.»

Based on this work, they decided to investigate whether miR -17-92 regulates T - and B - cell differentiation and function in the development of cGVHD.

It has been particularly difficult to measure changes in electrical functions of cells grown within Organ Chips that are normally electrically active, such as neuronal cells in the brain or beating heart cells, both during their differentiation and in response to drugs.

The study focuses on «stemness,» defined as the potential for self - renewal and differentiation from the cell of origin, and on «stemness indices» developed during postdoctoral research conducted by Tathiane Malta as part of a project supported by FAPESP and with Houtan Noushmehr, a professor in FMRP - USP's Genetics Department, as principal investigator.

The study «Elastase levels and activity are increased in dystrophic muscle and impair myoblast cell survival, proliferation and differentiation» is published in the journal Scientific Reports.

The geneticists at MLU were able to demonstrate that this process already operates at a very early stage in meiosis and corresponds temporally to the sexual differentiation onset of female germ cells.

Through the mTOR signalling pathway, it is involved in the regulation of many cellular processes, including cell survival, metabolism, proliferation, differentiation, and senescence.

«I think it will mark a paradigm shift» in how scientists understand stem cell differentiation, he adds.

The study, publishing July 27 in the open access journal PLOS Biology departs from the view that cell differentiation follows step - by - step instructions.

The new technique could also be useful in understanding how stem cells change oxidation properties during differentiation into other cell types.

The paper is published online in Cell Death & Differentiation, a Nature journal.

The results showed that, when applied, a long - term inhibition of Rho - kinase signaling increased the expressions of chondrocyte - specific genes and differentiation markers in human chondrosarcoma 2/8 cells.

In a previous study, Professor Schmidt - Ott and his team discovered that it regulates the differentiation of epithelial cells — they line the cavities and surfaces of structures throughout the body — in the mouse embryIn a previous study, Professor Schmidt - Ott and his team discovered that it regulates the differentiation of epithelial cells — they line the cavities and surfaces of structures throughout the body — in the mouse embryin the mouse embryo.