Sentences with phrase «cell differentiation on»

Porcine bone marrow stromal cell differentiation on heparin - adsorbed poly (e-caprolactone)- tricalcium phosphate - collagen scaffolds.

By monitoring stem cell differentiation on gels that mimic the stiffness and nanofibrous structure of biological tissue, researchers have identified the specific molecules that stem cells use when selecting bone and cartilage fates.

All the interdisciplinary skills and knowledge he had gathered during his scientific training — which had covered biochemistry, biotechnology, biomaterials, and stem cell biology — put him «in a very advantageous position to address this question» of how to develop nanoparticles that could modulate stem cell differentiation on demand, he says.

Not exact matches

A 2016 study observed the influence of the monk fruit component, mogrol, on fat accumulation and found that it inhibited the differentiation of pre-adipocytes (pre-fat cells) into mature adipocytes (fat cells)(11).

Their findings affirm Engler's prior work on the relationship between matrix stiffness and stem cell differentiations.

Now, in a new study published today, Sept. 8, in the Proceedings of the National Academy of Sciences, a team of researchers from the University of Wisconsin - Madison has added a new wrinkle to the cell differentiation equation, showing that the stiffness of the surfaces on which stem cells are grown can exert a profound influence on cell fate.

The study sought to test whether the surface alone, absent any added soluble factors to influence cell fate decisions, can have an effect on differentiation.

Based on this work, they decided to investigate whether miR -17-92 regulates T - and B - cell differentiation and function in the development of cGVHD.

A membrane — designed to support the cultivation and differentiation of human nasal epithelial stem cells — was inserted into a small chamber on the device and fresh or contaminated air was fed through a tiny channel.

The study focuses on «stemness,» defined as the potential for self - renewal and differentiation from the cell of origin, and on «stemness indices» developed during postdoctoral research conducted by Tathiane Malta as part of a project supported by FAPESP and with Houtan Noushmehr, a professor in FMRP - USP's Genetics Department, as principal investigator.

The research has also investigated the role of Rho - kinase inhibition on cellular - scale protein expression and stimulation of cellular differentiation of fibroblast cells.

Because these organisms are excellent models for understanding stem cell biology, researchers were able to shed light on the earliest stages of follicle cell differentiation, a previously poorly understood area of developmental biology.

In order to avoid differentiation and to remain pluripotent, these stem cells are dependent on signals from their neighbouring cells.

On the flip side, those genes needed for differentiation, which were repressed in the progenitor cells, had their epigenetic repression removed.»

«We have discovered that by timing the inhibition of STAT3 — like an «on / off» light switch — we can transiently expand the satellite - cell population followed by their differentiation into mature muscle cells.»

To bypass the challenge, the team relied on their complementary expertise in genome engineering, stem cell differentiation into neurons, and genomic analysis of alternative splicing.

Although this human Gut Chip recreated the villus epithelium of normal intestine and enabled new insights into how flow and cyclic peristalsis affects intestinal differentiation and function, it could not be used to study processes that relied on normal intestinal cells from individual donors, which, for example, is crucial for studying patient - specific responses for personalized medicine.

Research conducted at Japan's National Institute for Materials Science built on previous findings that gold nanoparticles can encourage stem cells in the bone marrow to differentiate into bone cells, and that specific biomolecules can inhibit or promote stem cell differentiation.

I've still kept my own lab going focusing on understanding what pluripotent stem cells really are, and the extrinsic signals that govern their self - renewal and differentiation.

The positively charged and neutral nanoparticles mildly inhibited stem cell proliferation but had no effect on their differentiation into bone cells.

They then used human stem cells derived from bone marrow that would normally become bone cells to test the effects of the nanoparticles on stem cell proliferation and differentiation.

The process that sets a stem cell on the path to either self - renewal or differentiation was thought to be a highly complex web of genetic and environmental interactions.

which is focused on mouse models of adult stem cell differentiation and tissue regeneration.

Such research on the basic processes of cell differentiation holds out the promise of dramatic new medical interventions and cures.

Seeking fresh sources, they looked for cells that express the gene neurogenin 3, a potential sign of cell differentiation because it is the first gene to only switch on in pancreatic islets during embryonic development.

Special focus is placed on Rho - kinase inhibition, relating to its potential to promote and support extracellular matrix production in cultured chondrocytes and its role in fibroblast cells as a part of direct chemical cellular differentiation.

«Our experiments showed that restoring H19 expression hindered by too much p53 restored «protective differentiation» of osteoblasts to counter events of tumor growth early on in bone cancer,» said co-author, Ihor Lemischka, PhD, Director of The Black Family Stem Cell Institute within the Icahn School of Medicine.

Then, putting these cells on natural scaffolds, researchers facilitated differentiation of these stem cells back to corneal cells.

The International Human Epigenome Consortium presents a series of studies on how epigenetics influences immunity, cell lineage determination, and differentiation.

Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes

This ability of NGF to sustain sympathetic neurons in culture has since made possible some ingenious and revealing experiments on neuronal differentiation [see «The Chemical Differentiation of Nervdifferentiation [see «The Chemical Differentiation of NervDifferentiation of Nerve Cells.»

His work has focused on discovering and characterizing novel small molecules that can control various cell fates and functions, including stem cell maintenance, activation, differentiation and reprogramming in various developmental stages and tissues.

We will develop mathematical models to predict the pathways of differentiation from naive to memory and effector T - cell subsets based on the characterisation of surface marker expression, transcription factors and cytokines production at early and late time points after immunisation.

Our work focuses on discovering and characterizing novel small molecules that can control cell fate and function in numerous cell types, including stem cell maintenance, activation, differentiation, and reprogramming in various developmental stages and tissues.

This includes helpful information on harvesting adult stem cells for differentiation, optimizing the setup of transwell inserts, and monitoring and identifying successful versus unsuccessful differentiation in the air - liquid interface system.

Cell therapy, as envisaged by the teams of I - Stem, is primarily based on the identification of experimental protocols that can specifically guide differentiation of pluripotent cells to a cell fate, which presents a interest for the replacement of the defective cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, etCell therapy, as envisaged by the teams of I - Stem, is primarily based on the identification of experimental protocols that can specifically guide differentiation of pluripotent cells to a cell fate, which presents a interest for the replacement of the defective cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, etcell fate, which presents a interest for the replacement of the defective cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, etcell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, etc.).

We examine their original thymic development: selection on hematopoietic cells leading to the acquisition of an original differentiation program.

The influence of the src - family kinases, Lck and Fyn, on T cell differentiation, survival and activation.

They include reduced lymphocyte repertoire, increasing clonality and increasing autoreactivity.5, 7,8 Recent work has focused on intrinsic cell defects, which alter T cell activation threshold, induction of cellular senescence and differentiation into short - lived effector or long - lived memory cells.

NeuroStemcell is focused on the identification and systematic comparison of progenitor cell lines with the most favourable characteristics for mesDA and striatal GABAergic neuronal differentiation, generated either directly from human embryonic stem (ES) cells, from Neural Stem (NS) cells derived from ES cells or fetal brain, from induced Pluripotent Stem (iPS) cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animals models.

We have specifically studied the potential of endothelial differentiation of MSC and the impact of a tyrosine kinase inhibitor (Imatinib mesylate) on this type of stem cells.

TTD - specific cutaneous and anaemic features, on the other hand, are thought to result from a specific kind of transcriptional insufficiency caused by depletion of unstable TFIIH during the terminal differentiation of skin, hair - shaft, and blood cells [16,24].

Bartosz Balana (Ravens, TUD)-- «Influence of culture conditions on differentiation and bioelectrical properties of human mesenchymal stem cells» (2005)

Effects of dehydroepiandrosterone on proliferation and differentiation of chromaffin progenitor cells.

Our laboratory focuses on the fundamental events involved in cell fate determination and differentiation and organogenesis.

Until now, scientific dogma has stated that differentiation is a one - way path; once cells specialize, they can not return to the flexible stem - cell state on their own.

Differences between in vitro viability and differentiation and in vivo bone - forming efficacy of human mesenchymal stem cells cultured on PCL - TCP scaffolds.

Can we artificially speed up or slow down cells and what affect will this have on differentiation capacity?

Colonization and osteogenic differentiation of different stem cell sources on electrospun nanofiber meshes.

Here, Kate presents her work on that show that culture of human ES cells on human recombinant laminin - 521 and laminin - 111 substrates significantly improve hepatocyte differentiation, maturation, function and stabilization of phenotype compared to Matrigel cultured cells.