Sentences with phrase «cell differentiation potential»

The findings are reported in the article «A Sox2 distal enhancer cluster regulates embryonic stem cell differentiation potential» published online December 15 in Genes & Development.

Not exact matches

Breastmilk is a novel source of stem cells with multilineage differentiation potential.

Stem cells have also been identified in human milk, and have the potential to differentiate into mammary epithelial lineages under mammary differentiation conditions in vitro, as well as other cell types in corresponding microenvironments, including bone cells, brain cells, liver cells, pancreatic beta cells and heart cells.

The study focuses on «stemness,» defined as the potential for self - renewal and differentiation from the cell of origin, and on «stemness indices» developed during postdoctoral research conducted by Tathiane Malta as part of a project supported by FAPESP and with Houtan Noushmehr, a professor in FMRP - USP's Genetics Department, as principal investigator.

These findings reveal molecular factors that can be used to evaluate the differentiation potential of different cell lines, which should expedite the progress of iPS cells to clinical use.

Seeking fresh sources, they looked for cells that express the gene neurogenin 3, a potential sign of cell differentiation because it is the first gene to only switch on in pancreatic islets during embryonic development.

Special focus is placed on Rho - kinase inhibition, relating to its potential to promote and support extracellular matrix production in cultured chondrocytes and its role in fibroblast cells as a part of direct chemical cellular differentiation.

«It suggests to us that targeting the pathways used in regulating cell fate decisions — how stem cells choose between cell proliferation and differentiation — could be a more effective way of halting tumours in their tracks and lead to potential new therapies.»

Researchers assessing the cardiac differentiation potential of several adipose - derived stem cells describe an optimal cell source

The differentiation of patient - specific induced pluripotent stem cells (iPSCs) into has the potential to provide differentiated cells to test drugs, model diseases, and, most importantly, to replace lost or damaged tissues.

harnessing the differentiation potential of pluripotent stem cells to derive interspecies chimera with potential clinical applications.

The exploration of the therapeutic potential of stem cells requires the characterization of their biological properties, the deciphering of the mechanisms that underlie their pluripotency and their capacity at differentiation, by the understanding of the signals that direct their fate towards discrete cell phenotypes... Their therapeutic use requests further, in particular in the case of substitutive therapies, the analysis of their capacities of integration in injured adult tissues and of their potential tumorigenicity, as well as the development of original ways of delivery.

Finally, I will show how we have combined our results to generate a model of hematopoietic differentiation where specific transcription factors control lineage regulatory regions; our model predicts many already known lineage - controlling factors as well as finds new potential regulators of hematopoietic differentiation such as ATF3 in monocytes and Tcf7l2 and Runx2 in NK cells.

We have specifically studied the potential of endothelial differentiation of MSC and the impact of a tyrosine kinase inhibitor (Imatinib mesylate) on this type of stem cells.

With potential therapeutic implications, Stainier and a colleague also recently discovered that endothelial cells, which line the blood vessels, play a critical role in inducing the development, or proper differentiation, of red blood cells, the transporters of oxygen.

Ihor Zahanich (Ravens, TUD)-- «Differentiation potential of human mesenchymal stem cells: expression of molecular markers, ion channels and gap junction channels» (2006)

Researchers from the Sloan - Kettering Institute, led by Dr. Lorenz Studer, have discovered a novel type of neural stem cell, which has a broader differentiation potential than previously identified neural stem cells.

Comparison of the differentiation potential of cell populations isolated from human lipoaspirate, trabecular bone tissue and periosteal tissue.

Dr. Studer and colleagues isolated and cloned a population of neural rosette cells (R - NSCs), which have an expanded neuronal subtype differentiation potential.

[3] H. Lin et al., «Influence of decellularized matrix derived from human mesenchymal stem cells on their proliferation, migration and multi-lineage differentiation potential,» Biomaterials, 33:4480 − 9, 2012.

Andreas Ettinger (Huttner, MPG)-- «Release of post-abscission midbodies from stem and cancer cells and potential links to differentiation» (2010)

When a stem cell divides, it has the potential to either remain as a stem cell (process known as «self - renewal») or to become a different type of cell with a more specialized function («differentiation»).

An improved differentiation strategy allows the production of iPSC - derived lung cells with improved regenerative and reparative potential.

Stem cells are the most favorable cell source for cell therapy, due to their inherent self - renewal properties and differentiation potential.

Applying these paradigms on various neural differentiation schemes of human pluripotent stem cells allows us to identify and isolate new types of neural stem and progenitor cells, to characterize their cellular properties and molecular foundations, to expose their progenitor origin and track their imminent potential, to reveal their in vivo counterparts and learn about their regenerative potential.

Nevertheless, cell lines with varying differentiation potential might also aid in study of molecular regulation of differentiation processes.

The fellow will drive a new project focusing on molecular mechanisms controlling the identity, self - renewal, and differentiation potential of skeletal stem cells.

In this way embryo - derived stem cell lines and ES cell differentiation may be providing access to potential «transition states,» required for lineage specification in vivo.

Both mouse and human iPSCs are similar to embryonic stem cells (ESCs) with respect to their morphology, cell behavior, gene expression, epigenetic status and differentiation potential both in culture and in vivo.

Her lab is examining the potential of using biomaterials for stem cell differentiation and engineering mesenchymal tissues.

A specific attention will be given to the identity, plasticity and differentiation potential of the cells required for the regeneration processes.

Finally, miR - 181a was recently shown to induce neuronal differentiation and a DA phenotype in human long - term, self - renewing, neuroepithelial - like stem cells [49], which supports the potential role for miR - 181a in regulating development of mDA neurons.

But others will still remain, such as the long - term karyotypic stability, appropriate in situ localization, and potential for wayward differentiation of somatic cells derived from hiPSCs.

The successful differentiation of iPS cells into RPE represents a significant advance in the search for a potential cell source for the treatment of human neural retinal diseases.

Given our extensive experiences in neuronal differentiation of hESCs [6], [7], [8] and the potential application of hESC - derived neurons in cell replacement therapies for neurodegenerative diseases, we designed a set of experiments aimed at developing a hESC - based automated assay for screening small molecules that have differential toxicity to hESC - derived NSCs and their differentiated neural progenies.

This poster describes the isolation and maintenance in culture of pluripotent stem cells, their differentiation, and the generation and potential uses of organoids.

Collectively, these data demonstrate that youthful circulating factors can restore the self - renewal and differentiation potential of aged SVZ stem cells, and this effect can persist for some time after isolation from the mouse brain.