Sentences with phrase «cell differentiation processes»

In addition to p53, there are other transcriptional activatory mechanisms that are not well understood for the most part and which operate in response to mitogenic stimulation (11, 12), transforming growth factor - β (13, 14, 15), and aberrant oncogenic signals (16, 17) or during a number of cell differentiation processes (18, 19).

Heatmaps of the 50 concise clusters for All Genes, Transcription Factors and ESTs according to their timing of induction or suppression during the normal ES cell differentiation process.

The bottom row consists of three tools that offer: detailed organization of specific gene expression patterns (Expression Waves) during the differentiation process (bottom left); animation of KEGG pathways organized by successive days of differentiation (Pathway Animations, bottom middle); and, a search engine to obtain the expression of any transcript or groups of transcripts in the Affymetrix 430 v. 2 arrays during the ES cell differentiation process (bottom right).

Not exact matches

However, it remains unclear how these different stem cells populations balance proliferation, differentiation and migration during the healing process.

After deciphering this natural differentiation process, the investigators duplicated it in the laboratory dish by adding a sequence of proteins, called growth factors, to the fluid bathing the stem cells.

Scientists know that different auxin concentrations in cells and their environment assume a key role in these differentiation processes.

Directing stem cell differentiation is like following a complex recipe, involving a long list of ingredients and steps that make the process costly and inefficient.

The geneticists at MLU were able to demonstrate that this process already operates at a very early stage in meiosis and corresponds temporally to the sexual differentiation onset of female germ cells.

Through the mTOR signalling pathway, it is involved in the regulation of many cellular processes, including cell survival, metabolism, proliferation, differentiation, and senescence.

Two recent studies describe these kinds of mechanisms: one of them, published in the journal Molecular Systems Biology, describes the process through which cells stop growing due cell differentiation; the second one, published in Journal of Cell Science, describes plants» cell replenishment after being damacell differentiation; the second one, published in Journal of Cell Science, describes plants» cell replenishment after being damaCell Science, describes plants» cell replenishment after being damacell replenishment after being damaged.

But like the medieval alchemists, today's cloning and stem cell biologists are working largely with processes they don't fully understand: What actually happens inside the oocyte to reprogram the nucleus is still a mystery, and scientists have a lot to learn before they can direct a cell's differentiation as smoothly as nature's program of development does every time fertilized egg gives rise to the multiple cell types that make up a live baby.

The laboratory process, described in the journal Scientific Reports, entails genetically modifying a line of human embryonic stem cells to become fluorescent upon their differentiation to retinal ganglion cells, and then using that cell line for development of new differentiation methods and characterization of the resulting cells.

The study revealed that growth factors — especially one known as growth differentiation factor 9 — coming from the eggs drove the feeding tube multiplication and growth process, acting directly upon the genetic machinery of the follicle cells surrounding the egg.

Senior researcher Mori continues, «We see UPR working «backstage», so to speak, to support the main actors during cell differentiation and thereby orchestrating various biological processes»

Failure of this regulation not only impairs the process of development, but also contributes to the reversal of cell differentiation and the uncontrolled cell growth that are the hallmarks of cancer.

This process, called cell differentiation, gives rise to all the various cell types, such as nerve, muscle, or blood cells, which are diverse in shape and function and make up tissues and organs.

Although this human Gut Chip recreated the villus epithelium of normal intestine and enabled new insights into how flow and cyclic peristalsis affects intestinal differentiation and function, it could not be used to study processes that relied on normal intestinal cells from individual donors, which, for example, is crucial for studying patient - specific responses for personalized medicine.

In order to learn more about this process, Alexander Skupin and his team treated blood stem cells from mice with growth hormones and then watched closely how these progenitor cells behaved during their differentiation into white or red blood cells.

However, in developing brain cells, the researchers found TLR3 activation also influences 41 genes that add up to a double whammy in this model — diminished stem cell differentiation into brain cells and increased cell suicide, a carefully controlled process known as apoptosis.

Knowing how cells exert force and sense mechanical feedback in their microenvironment is crucial to understanding how they activate a wide range of cellular functions, such as cell reproduction, differentiation and adhesion — basic physiological processes that underlie embryo development, tumor metastasis, wound healing and many other aspects of human health and disease.

«Our findings represent two key processes of stem cell differentiation,» said Lickert.

The process that sets a stem cell on the path to either self - renewal or differentiation was thought to be a highly complex web of genetic and environmental interactions.

A promising type of therapy called differentiation therapy targets these malignant cells so that they can resume the process of differentiating into mature cells.

This screening approach revealed several microRNA molecules that induce the process of cell differentiation, and those are key to developing new drugs.

Such research on the basic processes of cell differentiation holds out the promise of dramatic new medical interventions and cures.

Combined, the molecular processes involving the HIPPO / TAZ / YAP and Gαs feedback circuit indicate it acts as a fulcrum that balances Schwann cell proliferation and differentiation in peripheral nerves, according to the authors.

«The targeted differentiation of human pluripotent stem cells is often a long and rather inefficient process.

The authors concluded that the CaP / gel / Ti implants fabricated using their urease process not only enhanced the proliferation of stem cells and differentiation of bone cells, but also the bone bonding ability of the implants.

«Yet we know little about the genes and molecular pathways that keep stem cells from turning into regular tissue cells — a process known as differentiation.»

«Irreversible resolution of lineage priming appears to be a common feature of blood cell differentiation and may in fact be a general feature of other developmental processes.»

Commitment toward differentiation of pluripotent stem cells is a multi-step process that requires combination of signals.

He uses the paradigm of nuclear hormone receptor activation / signaling and the contribution of this process to myeloid cell differentiation, function, and to diseases, involving these cells, such as atherosclerosis, tissue regeneration, metabolic, and various inflammatory disorders, as his model systems.

This process (see figure) started with spin - embryoid body (spin - EB) formation from cultures of single - cell hiPSC suspensions in 96 well plates, and the subsequent addition of BMP4 and FGF - 2 to induce mesoderm differentiation, and then VEGF and SCF to induce hematopoietic differentiation.

Working with the research group led by Vijay G. Sankaran, M.D., Ph.D., of Boston Children's Hospital and the Broad Institute, Rajiv K. Khajuria, a doctoral student at Charité's Berlin - Brandenburg School for Regenerative Therapies, studied the molecular processes involved in the differentiation of stem cells and their development into mature blood cells.

Conrad Hal Waddington coined a classical metaphor for the process of cell differentiation during development: An epigenetic landscape characterized by valleys of different levels, and hills to separate them.

We have identified a number of key transcription factors that are deregulated during this process, and we are using this information to investigate mechanisms by which differentiation can be reprogrammed in tumour cells.

«We can no longer view differentiated cells as being a static endpoint of the differentiation process,» says Izpisúa Belmonte, who also directs the CMRB.

The project will focus on answering the question, how an embryonic stem cell computes cues from its environment to elicit a regulated, exact cell fate choice during a process called «differentiation».

The product combines pancreatic progenitor cells called PEC - 01, produced by a directed differentiation process, encapsulated with a semi-permeable device called the Encaptra ® Drug Delivery System, both are proprietary technologies.

When a stem cell divides, it has the potential to either remain as a stem cell (process known as «self - renewal») or to become a different type of cell with a more specialized function («differentiation»).

The portfolio includes U.S. and foreign patents and applications directed to culture, expansion and scale - up of pluripotent stem cells and cell types derived therefrom, various differentiation processes for production of mesendoderm, definitive endoderm, PEC - 01, and endocrine precursors, as well as claims directed to the Company's Encaptra ® macro-encapsulation device platform.

Cell Therapy Catapult will develop a scalable manufacturing and differentiation process for AST - VAC2 in order to support the downstream demands of clinical trials and ultimately commercialization.

The pool of stem cells in the bone marrow is continuously undergoing a process of self - renewal and differentiation.

Novocell scientists pioneered a differentiation process that successfully engineers hES cells into definitive and pancreatic endoderm cells necessary for pancreas formation.

This ensures that sister cultures from the same subjects are similar in cell composition and differentiation state, and it avoids the influence of experimental conditions on the differentiation process (1).

Plant roots grow due to cell division in the meristem and subsequent cell elongation and differentiation, a tightly coordinated process that ensures growth and adaptation to the changing environment.

Izpisua Belmonte and colleagues published work in the journal Nature last year reporting that they had been able to integrate human stem cells into early - stage mouse embryos so that the human stem cells began the first stages of differentiation — they appeared to begin the process of generating precursors of the body's various tissues and organs.

Nevertheless, cell lines with varying differentiation potential might also aid in study of molecular regulation of differentiation processes.

The early cardiac markers and transcription factors (Gata4, Mef2c, Hind I, Nkx2 - 5 and beta - Mhc) were examined in iPS cell lines 11.1 and 4.1 during the cardiac differentiation process (differentiation day 0, day 3, day 6 and day 9).

The process, known as differentiation, attempts to replicate in the lab the natural development of neurons from undifferentiated stem cells in a human embryo.