Sentences with phrase «cell differentiation towards»
Developmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation towards authentic DARPP - 32 + medium - sized spiny neurons
http://www.neurostemcell.org/ Not exact matches
Drosha degrades the messenger RNA for NFIB in the adult hippocampal stem cells and prevents the expression of this transcription factor which is necessary for the differentiation of oligodendrocytes and thus blocks their development and therefore biases differentiation towards neurons.
Their analysis of more than 4,000 individual tumor cells, the largest effort to date in brain tumors, finds three developmental categories of cancer cells — one resembling neural stem cells and two characterized by sets of genes indicting paths towards differentiation.
«We also think this method could be applied towards the development of culture conditions during differentiation of human stem cells.
«Together,» explains Dr. Ramiro, «the results indicate that CTCF is important for maintaining the germinal center differentiation program and prevents premature differentiation towards plasma cells.»
The exploration of the therapeutic potential of stem cells requires the characterization of their biological properties, the deciphering of the mechanisms that underlie their pluripotency and their capacity at differentiation, by the understanding of the signals that direct their fate towards discrete cell phenotypes... Their therapeutic use requests further, in particular in the case of substitutive therapies, the analysis of their capacities of integration in injured adult tissues and of their potential tumorigenicity, as well as the development of original ways of delivery.
This is posited to create a safer and more robust source of induced pluripotent stem cells (iPSCs) from patient samples for subsequent differentiation towards transplantable RGCs.
A future aspect of our mouse work is directed towards use of ES cell differentiation in culture as a model for epigenetic decisions and stem cell manipulations.
Stem cell ‐ based therapies under investigation as a strategy for the treatment of Type 1 diabetes mellitus (T1DM) include the differentiation of cells towards engineered β cells [1] and the use of mesenchymal stem cells (MSCs) in the prevention or reversal of autoimmune and chemical ‐ induced diabetes [2].
Researchers find that Insulin - like growth factor / Insulin - mediated induction of mesodermal differentiation aids the production of cardiac progenitor cells from embryonic stem cells towards a strategy to boost cardiac cell production.
However, when these fractions are placed into differentiation either in vivo or in vitro, the V+S + population tends to colonize the PrEn lineages, while V − S + cells tend towards epiblast.
The choice of the somatic cell for reprogramming, the reprogramming technology chosen, and the differentiation techniques utilised, all work synergistically towards the production of mature iPSCs - derived chondrocytes which are comparable to patient - derived chondrocytes, in line with Good Manufacturing Practice guidelines for an «off - the - shelf» stem cell product.