«Secondary benefits of this trial include the significant improvement in clinical care for children with sickle
cell disease at each of the 29 sites because each location had a designated hematologist, neurologist, neuroradiologist and psychologist working as a team to identify and decrease further injury to the brain in this vulnerable population.»
Not exact matches
The companies» R&D will focus on on a gene mutation present in a wide swath of patients with ALS, a degenerative nervous system
disease that eats away
at nerve
cells and weakens muscles.
He conducted his postdoctoral research
at Brigham and Women's Hospital / Harvard Medical School, where he researched the role of the Wnt signaling pathway in mouse models of kidney
disease, and was part of a team that discovered a stem
cell subtype responsible for solid organ fibrosis.
bluebird bio (BLUE)- The company's BCMA CAR - T drug candidate bb2121 remains attractive despite overblown fears on durability (peak sales of $ 2 billion or more), LentiGlobin has a good shot
at success in TDT (Transfusion - Dependent ß - Thalassemia) and SCD (Severe Sickle
Cell Disease), and they have a strong cash position.
What Stephen Hawking Missed: Small Biotechs Developing Promising
Cell Therapies for Devastating Disease Source: Streetwise Reports (5/2/18) In the second of a two - part series exploring the disruptive cell therapy space, Maxim Group analyst Jason McCarthy takes a look at small - cap companies targeting big - ticket indications and their potential to drive blockbuster value for both patients and invest
Cell Therapies for Devastating
Disease Source: Streetwise Reports (5/2/18) In the second of a two - part series exploring the disruptive
cell therapy space, Maxim Group analyst Jason McCarthy takes a look at small - cap companies targeting big - ticket indications and their potential to drive blockbuster value for both patients and invest
cell therapy space, Maxim Group analyst Jason McCarthy takes a look
at small - cap companies targeting big - ticket indications and their potential to drive blockbuster value for both patients and investors.
Government funding for research into sickle -
cell disease is pitifully inadequate (the Sickle - Cell Society receives no government funds at a
cell disease is pitifully inadequate (the Sickle -
Cell Society receives no government funds at a
Cell Society receives no government funds
at all).
The strict definition of celiac
disease — positive antibodies to gliadin, intestinal endomysium, and tissue transglutaminase, together with the presence of HLA - DQ2 or HLA - DQ8 genes and an intestinal biopsy that shows
at least 20 - 25 CD3
cells per 100 epithelial
cells — will account for about 75 - 80 % of all those sensitive to gluten.
It offers cardio protection, it helps lower bad cholesterol, it may help prevent the progression of multiple sclerosis, it has the ability to regenerate brain
cells after a stroke, it has the ability to cross the blood - brain barrier to potentially ward off Alzheimer's
disease, apparently it's good
at wiping amyloid plaque from the brain (which studies haves linked to Alzheimer's), it may help to prevent certain types of cancer, and studies have shown that it inhibits cancer
cell growth and metastases (meaning it keeps cancer from spreading).
No observed local immunological response
at cell level after five years of oats in adult coeliac
disease.
We are the parents of a severely food allergic college age son, Morgan, first diagnosed
at the age of 9 months old with life threatening allergies to peanuts, (tree nuts, sesame, fish and shellfish came later); and a grown daughter, Michaela, diagnosed with celiac
disease and a mast
cell mediated disorder.
Breech Twins and higher order multiples Previous CS Pre-Eclampsia Placenta praevia Cervical incompetence Previous late stillbirth Previous premature birth Grand multiparty Age under 18 Age over 35 Smoking Drug use Severe mental health issue Epilepsy Type 1 diabetes Type 2 diabetes Gestational diabetes Asthma GBS positive Abnormal antibodies Transplant recipient Congenital heart
disease Known foetal abnormality Immunosuppressive medication MS Physical disability Intellectual disability Hypothyroidism Hyperthyroidism Previous shoulder dystocia Previous 3rd or 4th degree tear Sickle
Cell anaemia BMI under 18 or over 35
at conception Previous massive PPH APH in current pregnancy HIV / AIDS Hepatitis B or C Active TB IUGR Oligohydramnios Polyhydramnios Child previously removed from custody because of abuse Uterine abnormalities such as uterine septum or double uterus Previous uterine surgery for fibroids Chronic renal problems Hypertension Auto immune condition Previous stroke or blod clot Cancer Domestic violence or abusive home Prisoners Homeless women
(borrowed from Dr Kitty) Breech Twins and higher order multiples Previous CS Pre-Eclampsia Placenta praevia Cervical incompetence Previous late stillbirth Previous premature birth Grand multiparty Age under 18 Age over 35 Smoking Drug use Severe mental health issue Epilepsy Type 1 diabetes Type 2 diabetes Gestational diabetes Asthma GBS positive Abnormal antibodies Transplant recipient Congenital heart
disease Known foetal abnormality Immunosuppressive medication MS Physical disability Intellectual disability Hypothyroidism Hyperthyroidism Previous shoulder dystocia Previous 3rd or 4th degree tear Sickle
Cell anaemia BMI under 18 or over 35
at conception Previous massive PPH APH in current pregnancy HIV / AIDS Hepatitis B or C Active TB IUGR Oligohydramnios Polyhydramnios Child previously removed from custody because of abuse Uterine abnormalities such as uterine septum or double uterus Previous uterine surgery for fibroids Chronic renal problems Hypertension Auto immune condition Previous stroke or blod clot Cancer Domestic violence or abusive home Prisoners Homeless women
For instance, specific anti-T-cell therapies don't work
at all for rheumatoid arthritis (RA), and Edwards doesn't think T -
cells explained how the
disease persisted.
«But in this case, when this virus infects
cells, the virus makes its own transcription factors, and those sit on the human genome
at lupus risk variants (and
at the variants for other
diseases) and that's what we suspect is increasing risk for the
disease.»
«In theory, we could model progression of the
disease by reprogramming skin
cells from patients
at a range of ages, including before symptoms begin.
«Our study results are the first to argue that we may be able to treat inflammatory bowel
disease and protect against transplant rejection not only by blocking TNF alpha as is done currently, but also by stimulating ATG16L1 to prevent early death of
cells lining the gut,» says study senior investigator Ken Cadwell, PhD, an associate professor
at NYU School of Medicine and NYU Langone Health's Skirball Institute for Biomolecular Medicine.
McCallion's strategy to make sense of all this data looks
at the active genes in
cells affected by a
disease, groups of genes that interact with one another, their vulnerability to mutation and information from past scientific studies to filter more than a thousand gene candidates for
disease risk down to just a handful within any one implicated region.
The long - term persistence of CD8αα + T
cells where initial infection occurs may explain why patients have asymptomatic recurrences of genital herpes because these
cells constantly recognize and eliminate the virus, according to Jia Zhu, Ph.D., corresponding author, research assistant professor in Laboratory Medicine
at the University of Washington and an affiliate investigator in the Fred Hutch Vaccine and Infectious
Disease Division.
Human embryonic stem
cells are
at last being tested in common, potentially fatal
diseases such as heart failure and diabetes
At best, the scientists say, there is a 50 - 50 chance that the gene closest to a mutation will even be active in the
cell types affected by a
disease.
The team also needs to figure out which types of cancer Th17
cells respond to, and
at which stage of the
disease.
They isolated blood
cells from HIV - positive patients on antiretroviral therapy and
at different stages of
disease progression, as well as
cells from non-infected individuals.
In a groundbreaking study that provides scientists with a critical new understanding of stem
cell development and its role in disease, UCLA researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research led by Dr. Kathrin Plath, professor of biological chemistry, have established a first - of - its - kind methodology that defines the unique stages by which specialized cells are reprogrammed into stem cells that resemble those found in the emb
cell development and its role in
disease, UCLA researchers
at the Eli and Edythe Broad Center of Regenerative Medicine and Stem
Cell Research led by Dr. Kathrin Plath, professor of biological chemistry, have established a first - of - its - kind methodology that defines the unique stages by which specialized cells are reprogrammed into stem cells that resemble those found in the emb
Cell Research led by Dr. Kathrin Plath, professor of biological chemistry, have established a first - of - its - kind methodology that defines the unique stages by which specialized
cells are reprogrammed into stem
cells that resemble those found in the embryo.
«This research represents an important step toward the goal of being able to better treat thyroid
diseases and being able to permanently rescue thyroid function through the transplantation of a patient's own engineered pluripotent stem
cells,» explained co-corresponding author Anthony N. Hollenberg, MD, Chief of the Division of Endocrinology, Diabetes and Metabolism
at BIDMC and Professor of Medicine
at Harvard Medical School.
A team of researchers
at the Stanford University School of Medicine has used a gene - editing tool known as CRISPR to repair the gene that causes sickle
cell disease in human stem
cells, which they say is a key step toward developing a gene therapy for the disorder.
Since pseudouridine modifications may affect various RNA molecules in different types of normal and malignant
cells, «our discoveries pave the way for future avenues of research aimed
at exploring the role of pseudouridine in human development
disease,» concludes Cristian Bellodi.
Last year Cuervo collaborated with Sheng Zhang, a professor
at The University of Texas Health Science Center
at Houston on experiments showing that huntingtin — the Huntington's
disease protein — helps the
cell's autophagy system identify what it should eliminate.
In preclinical studies using
cell models that mimicked liver
cells of patients with the rare
disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS ONE from the Perelman School of Medicine
at the University of Pennsylvania.
The idea to specifically study this group of patients was based on groundbreaking research Garon published in the New England Journal of Medicine last year, which found that among patients who received pembrolizumab, those with PD - L1 expression on
at least 50 percent of their cancer
cells showed the longest survival and
disease control.
«We found that a particular vaginal bacterium, Gardnerella vaginalis, did not cause infection during exposure to the urinary tract, but it damaged the
cells on the surface of the bladder and caused E. coli from a previous UTI to start multiplying, leading to another bout of
disease,» said the study's senior author, Amanda Lewis, PhD, an assistant professor of molecular microbiology and of obstetrics and gynecology
at Washington University.
At the same time, researchers have found that much smaller protein clusters called oligomers — made of only a few copies of these proteins — can be highly toxic to motor neuron - like
cells grown in the lab and thus are more likely to be the chief causes of brain -
cell death in these
diseases.
Researchers
at Nagoya University have been studying the therapeutic effect of T
cells, vital
disease - fighting components in our body's immune system, for fighting cancer.
We believe that they will also lead to the development of a whole new range of therapies for neurodegenerative
diseases of the central nervous system,» explains corresponding author of the study Jihwan Song, professor and director of Neural Regeneration and Therapy Group
at the CHA Stem
Cell Institute of CHA University.
Vamsi Mootha, a mitochondrial biologist
at Massachusetts General Hospital, his graduate student Isha Jain, and their colleagues used a popular DNA - editing tool called CRISPR to knock out about 18,000 different genes in human
cells that were altered to have the same problems as people with mitochondrial
diseases.
But their prominence
at sites where nerve
cells are damaged by the
disease means they deserve careful scrutiny in the desperate search for ways to arrest the most salient cause of dementia.
Researchers
at the University of Louisville have discovered a mechanism involved in skeletal muscle repair that may enable clinicians to boost the effectiveness of adult stem
cell therapies for
diseases such as muscular dystrophy.
But a handful of researchers are getting better
at deciphering these gaseous clues, bringing us closer to the day when a kind of
disease breathalyzer could be part of a routine checkup or maybe even a
cell phone app.
«This is the first demonstration that
cells carrying a genetic
disease are capable of spreading into the normal mammalian brain and lead to the manifestation of behavioral abnormalities associated with the
disease,» says Francesca Cicchetti, professor
at the Université Laval Faculty of Medecine and researcher
at Centre de recherche du CHU de Québec - Université Laval.
Comparing his study to Surmeier's, Redmond noted: «One is an approach to try to minimize
disease progression or maybe even get some recovery, the other is more aimed
at the other end, after (dopamine - producing]
cells are already dead.»
Mice transplanted with
cells grown from a patient suffering from Huntington's
disease (HD) develop the clinical features and brain pathology of that patient, suggests a study published in the latest issue of Acta Neuropathologica by CHA University in Korea, in collaboration with researchers
at Université Laval in Québec City, Canada.
Previous research conducted
at Mount Sinai found that the trafficking of protein molecules between the nucleus (the cellular compartment containing the genetic information of the
cell) and the cytoplasm is altered in neurodegenerative
disease.
In research that has implications for diabetes and other metabolic
diseases, an international study based
at UT Southwestern Medical Center found that the protein connexin 43 (Cx43) forms
cell - to -
cell communication channels on the surface of emerging beige fat
cells that amplify the signals from those few nerve fibers.
«The compounds identified in this study, when administered orally, both reduced the inflammation that is a hallmark of multiple sclerosis and protected against the nerve
cell damage seen in mouse models of the
disease,» said Jeffery Haines, PhD, a post-doctoral fellow
at Mount Sinai and the study's lead author.
Researchers from Howard University will present their findings today
at the American Physiological Society's Physiological and Pathophysiological Consequences of Sickle
Cell Disease conference in Washington, D.C.
«Our study reveals a new mechanism that could be harnessed for biological therapies for lupus and other autoimmune
diseases, where the immune system mistakenly targets the body's own
cells,» says senior study author Boris Reizis, PhD, professor of Pathology and Medicine
at NYU Langone.
At first it was thought that only functioned as cellular debris warehouses but in recent years has been that could have an important role as a messenger between
cells of the body and now many groups focus their research on the role that could be played exosomes in various
diseases, including cancer.
«By learning how tau spreads, we may be able to stop it from jumping from neuron to neuron,» said Karen Duff, PhD, professor in the department of pathology and
cell biology (in the Taub Institute for Research on Alzheimer's
Disease and the Aging Brain) and professor of psychiatry (
at New York State Psychiatric Institute.)
A comparison of these two cancers, published April 9 in the journal Cancer
Cell, suggests that they are similar in origin, leading researchers
at the University of Cambridge to believe that devils simply may be
at greater risk for these kinds of
diseases.
Gene Yeo, a professor of cellular and molecular medicine
at UCSD, led the research and showed he could target RNA in living
cells, a first step toward treating
diseases like muscular dystrophy and neurodegeneration.
After an earlier stint as a senior writer
at Science, where she was widely known for her coverage of the Human Genome Project, Leslie returned as a deputy news editor in 2000, specializing in public health, infectious
diseases, stem
cells, and ecology.