Not exact matches
Venter reiterated this sentiment: «Using the combined power of our core areas of expertise — genomics, informatics, and stem
cell therapies, we are tackling one of the greatest medical / scientific and societal
challenges — aging and aging related
diseases,» he said in a statement.
«Using the combined power of our core areas of expertise — genomics, informatics, and stem
cell therapies, we are tackling one of the greatest medical / scientific and societal
challenges — aging and aging related
diseases,» said Dr. Venter.
«Mechanistic finding may help develop treatment for Ice Bucket
Challenge disease: Study blames a fault in the
cell's machine that cuts and pastes genetic instructions for a deadly motor neuron
disease.»
The mini-brain lasts about a month and it could be used to study a range of
challenges in neuroscience including transplanting nerve
cells that could help treat Parkinson's
disease and studies on how adult nerve stem
cells develop.
In new research, scientists reprogrammed skin
cells from patients with rare blood disorders into iPSCs, highlighting the great promise of these
cells in advancing understanding of those
challenging diseases — and eventually in treating them.
It's been
challenging to zoom in on the population of T
cells driving the
disease in part because when psoriasis is active, lesions are flooded with diverse T
cells.
But studying how the
cells of complex tissues like the mammary gland self - organize, make decisions as groups, and break down in
disease has been a
challenge to researchers.
A major
challenge has been to find a way to better understand the way the
disease affects human nerve
cells.
Cancer is a
disease of your
cells, and sorting out your cancer from all others is a daunting
challenge but one that cancer
cell biologists are furiously pursuing.
In a paper published in Scientific Reports, the HDNetDB team outlines the
challenges facing those investigating Huntington's
disease, explains how HDNetDB works and illustrates its effectiveness by discovering potential drug targets, which might help to prevent the neuronal
cell death observed in Huntington's
disease.
«Identifying gene variants that are general risk factors for neurological and psychiatric
disease is important, but understanding exactly which
cell types in the developing brain are compromised and what the consequences are is still extremely
challenging,» Pollen added.
The findings
challenge the long - held theory that leukemia
cells simply outperform healthy
cells by living longer and suggest that targeting this «death factor» may be a viable way of combating the
disease.
We've found innovative ways to treat
challenging diseases (the U.S. Food and Drug Administration's approval of CAR - T
cell therapy for certain blood cancers is our No. 8 story).
As expected, xenogeneic graft versus host
disease (GVHD), assessed clinically by dermatitis and hair loss, was observed in mice receiving
cells treated with both R5 - ZFNs and X4 - ZFNs in the absence of HIV
challenge.
However, despite its marked promise for
disease modeling, development of novel therapies, and regenerative medicine, stem
cell derived organoid technology faces many remaining
challenges.
«Using the combined power of our core areas of expertise — genomics, informatics, and stem
cell therapies, we are tackling one of the greatest medical / scientific and societal
challenges — aging and aging related
diseases,» said Dr. Venter.
But editing the DNA of
cells in a petri dish — or even curing a mouse of a
disease — is one thing; making the hot new technology work in humans is a whole other
challenge.
A major
challenge that will be addressed in the second phase of LINCS is to optimize the combinations of
cell types, perturbations and measurements of cellular responses to address a wider range of basic biological and
disease - related problems than was possible in the program's initial pilot stage, said Alan Michelson, M.D., Ph.D., senior investigator, Laboratory of Developmental Systems Biology, NHLBI, and co-chair of the NIH LINCS Project Implementation Team.
New therapies for disorders like Huntington's
disease are on the way, but getting the drugs to enter brain
cells can be a major
challenge.
Allogeneic
cell therapies from primary
cells for immunotherapy applications are especially
challenging because of the vigor with which tissue donors must be screened and qualified to prevent transmission of infectious
disease and ensure maintenance of an active donor pool.
«By getting stuff into the
cells, you can understand the
disease and hence design therapies,» says Armon Sharei, lead author of a recent article on a new and vector - free microfluidic transfection technique, addressing the transfection
challenge.