Sentences with phrase «cell disease pain»

Respect, trust, and the management of sickle cell disease pain in hospital: comparative analysis of concern - raising behaviors, preliminary model, and agenda for international collaborative research to inform practice.

Not exact matches

An overabundance of the bacteria Veillonella in the digestive tract may increase pain in patients with sickle cell disease (SCD).

Uncontrolled growth of these cells leads to anemia, bone pain, kidney problems, Gaucher disease, and myeloma.

«Out of balance: Gut bacterial makeup may exacerbate pain in sickle cell disease.»

In the disease state, the blood cells are sickle - shaped instead of round, leading to stabs of pain and eventual organ damage.

When sickle cell disease progresses, it can delay puberty and cause acute and chronic complications, including debilitating pain, life - threatening infections, damage to vital organs, and stroke.

«When pain was reported as low, sickle cell disease patients reported higher opioid use if they catastrophized, or focused their thinking on their pain, than if they didn't,» says Finan.

Patients with sickle cell disease are commonly prescribed a daily, long - acting painkiller taken at a constant dose, and a short - acting painkiller to be taken as needed for episodes of more severe pain.

Their studies indicate that the two conditions common in sickle cell disease, dramatically increase red blood cells» adhesion to the lining of blood vessels walls and the debilitating pain crises that can result.

The new findings and the fact that patients with sickle cell disease have significant variability in their nitric oxide levels — even during a pain crisis — likely explains why, Ikuta said.

The next step will be to test it with live cells and the researchers hope eventually to, for example alleviate pain, stop epileptic seizures, and reduce the symptoms of Parkinsons disease, using exactly the required dose at exactly the affected cells.

Photoreactive compounds developed by scientists of Ludwig - Maximilians - Universitaet (LMU) in Munich directly modulate nerve - cell function, and open new routes to the treatment of neurological diseases, including chronic pain and certain types of visual impairment.

Dr. Sharma theorized that the diagnosis of sleep disordered breathing could be missed in this population because adults with sickle cell disease are not generally obese, a common risk factor for apnea, and daytime sleepiness is attributed to the pain medications necessary to treat symptoms of the disease.

ASH is alarmed about the opioid crisis; however, it is concerned about potential adverse effects that policy changes could have on the administration of necessary and appropriate pain medicine for patients with hematologic conditions such as sickle cell disease (SCD), blood cancers, and other bleeding disorders.

The disease is characterized by profound fatigue and disability lasting for at least 6 mo, episodes of cognitive dysfunction, sleep disturbance, autonomic abnormalities, chronic or intermittent pain syndromes, microbiome abnormalities (1), cerebral cytokine dysregulation (2), natural killer cell dysfunction (3), and other symptoms that are made worse by exertion of any kind (4).

The drug, called SelG1, also reduced the frequency of pain crises in people with sickle cell disease and reduced the number of days they spent in the hospital.

Endocrinologist Vin Tangpricha notes that Emory studies are looking at vitamin D in the context of tuberculosis, sepsis, sickle cell disease, cancer, cystic fibrosis and pain sensitivity.

Symptoms of sickle cell disease include swelling of the hands and feet, pain due to clogging of blood vessels, anemia and stroke.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

Leveraging the unique insights of its founders and an internal team of outstanding scientists, the Company seeks to become an industry leader in the neural stem cell field with multiple therapeutic product candidates ranging from epilepsy and neuropathic pain to other potential opportunities in the broader neurodegenerative and neuropsychiatric disease space.

But the one that I am most proud of is the development (clinical trial) of the first and only remote telephonic mindfulness - based stress reduction program for individuals with Sickle Cell Disease and chronic pain.

Hants also created the first (and only clinical validated) remote, mindfulness - based intervention for individuals with Sickle Cell Disease and chronic pain.

Inflammation has been discovered to play roles in heart disease, cancer, dementia (by inflaming brain cells) and particularly chronic joint pain and muscle weakness.

One study made up of 37 teenagers with sickle cell disease found that higher levels of daily stress were associated with increases in same - day pain levels (7).

Men with this disease often have chills; fever; pain in the lower back and genital area; urinary frequency and urgency, often at night; burning or painful urination; body aches; and a demonstrable infection of the urinary tract as evidenced by white blood cells and bacteria in the urine.

It is extremely effective at treating back pain and arthritis, skin problems like hot - spots, reducing inflammation in the bladder, and can even help with chronic kidney disease by stimulating the cells in the kidney.

We utilize patented stem cell therapies to relieve pain, improve mobility, and treat complications associated with osteoarthritis, degenerative joint disease, hip dysplasia, and injuries to tendons, ligaments, and bones.

Faculty research interests and expertise include mechanisms of metastasis in cancer; gene therapy (including electroporation) in cancer; cell and molecular biology of tooth eruption; pharmacology and toxicology of aquatic species; environmental and ecological toxicology; cellular ultrastructure; environmental risk assessment; analytical pharmacology and toxicology; diagnostic neurophysiology; pharmacology of pain and inflammation; exercise physiology; xenobiotic metabolism and disposition; neurochemistry; pulmonary pharmacology; cardiovascular disease; and cetacean morphology.

Canine Platelet Rich Plasma (PRP) offers a safe and natural cell therapy to relieve the pain of joint disease or injury, promote healing, and reduce recovery time using your dog's own blood.

Stem cell treatment is gaining popularity in veterinary medicine as a means for treating chronic diseases, including arthritis pain (42, 43, 44).

Diseased tissue and the inflammatory cells liquify into pus which breaks through the overlying surface skin and drains leading to foul odor, pain, and discharge.

«Statins make regular users become older faster, leaving them open to long - term mental and physical decline, according to disturbing new research... Scientists have found the heart disease drug badly affects our stem cells, the internal medical system which repairs damage to our bodies and protects us from muscle and joint pain as well as memory loss.»

San Bruno, CA About Blog NSI Stem Cell has 4 locations in Florida and uses stem cell therapy injections to treat many types of conditions including joint pain, osteoarthritis, arthritis, diabetes, COPD, neuropathy, thyroid disease, back & neck pain, knee pain, and other health related problCell has 4 locations in Florida and uses stem cell therapy injections to treat many types of conditions including joint pain, osteoarthritis, arthritis, diabetes, COPD, neuropathy, thyroid disease, back & neck pain, knee pain, and other health related problcell therapy injections to treat many types of conditions including joint pain, osteoarthritis, arthritis, diabetes, COPD, neuropathy, thyroid disease, back & neck pain, knee pain, and other health related problems.

This subset of scales from the FES and their composite score has been used with families of children with asthma, diabetes, juvenile rheumatoid arthritis, recurrent abdominal pain, sickle cell disease, and those undergoing bone marrow transplant (BMT).