Sentences with phrase «cell disease produce»

Not exact matches

[1] It is comprised of a network of cells and organs working together to defend the body against infection and sickness by producing secretions and disease - fighting cells.

Interestingly, those who suffer from narcolepsy, a disease in which people are excessively tired and may spontaneously fall asleep during the day, also lack orexin due to a breakdown in the brain cells that produce it.

It's necessary, they argue, to protect the babies who would otherwise be born with mutated mitochondria - the power - producing bits of cells - which can lead to serious diseases that currently affect around one in every 6,500 children.

Either approach could produce enough HSCs to transplant and — pending further safety testing — potentially treat leukemia, sickle cell disease and other severe blood disorders.

An engineered bone that has its own marrow can encourage donor stem cells to produce blood, a feat that could help people with anaemia and rare immune diseases

Scientists use cell reprogramming techniques to produce cells in the lab so that they can study diseases.

ORDINARY cells from people with a genetic disease can be «fixed» by gene therapy and then reprogrammed to be stem cells that will produce a limitless supply of defect - free cells.

Characterized by tremors, rigidity, difficulty walking and other symptoms, Parkinson disease is caused by the destruction of brain cells that produce the neurotransmitter dopamine.

Comparing his study to Surmeier's, Redmond noted: «One is an approach to try to minimize disease progression or maybe even get some recovery, the other is more aimed at the other end, after (dopamine - producing] cells are already dead.»

In mice, the Runx2 knock - in myeloma cells produced greater tumor growth and a wider spread of disease compared with the original myeloma cells; conversely, the Runx2 knock - down cells had less tumor growth and disease spread.

«If we take one of these modified cells and treat it with a particular drug, if it doesn't produce light anymore, then this means the drug is a potential treatment for this disease,» Basu said.

Most importantly, these cells protected mice from developing diabetes in a model of disease, having the critical ability to produce insulin in response to changes in glucose levels.

The disease commonly starts in childhood and causes the body's own immune system to attack and destroy the insulin - producing cells in the pancreas, leaving the patient dependent on life - long insulin injections.

Specific immune cells have the ability to produce a healing factor that can promote wound repair in the intestine, a finding that could lead to new, potential therapeutic treatments for inflammatory bowel disease (IBD), according to a new research study.

«Only by understanding the complexities of what happens in specific cell - types found in specific areas of the brain during this disease can targeted treatments for Parkinson's disease be produced.»

By getting inside the cell and getting the body to produce intracellular proteins, we have the potential to address many diseases that today aren't druggable with small molecule drugs or biologics.

Thus, the technique could produce adult muscle cells in a dish that carry genetic diseases.

Research shows that in Parkinson's disease a brainstem region called the pedunculopontine nucleus (PPN) develops changes in DNA found in mitochondria — the batteries of the cell — as they produce and store energy that cells can use.

They believe a vaccine that stimulates the body to produce more of these cells could be effective at preventing flu viruses, including new strains that cross into humans from birds and pigs, from causing serious disease.

The study, published in Nature Communications, shows that membralin regulates the cell's machinery for producing beta - amyloid (or amyloid beta, Aβ), the protein that causes neurons to die in Alzheimer's disease.

Although some teams have managed to produce nearly pure colonies of certain kinds of neural cells from ES cells, no one has managed to concoct a recipe that will direct the cells to become, say, a pure population of dopamine - producing neurons that could replace those missing in Parkinson's disease.

Excessive or uncontrolled inflammation can actually make injuries worse and contribute to disease in a couple of different ways — by activating cell death processes, clogging and rupturing blood vessels and producing toxic molecules like free radicals.

COUNTLESS research projects around the world into cancer and other major diseases are producing bogus or misleading results because investigators are studying the wrong type of cell.

A few years ago, MS researchers were focused on a new type of immune cell called the Th - 17 cell, which appeared to be a key player in driving the neuronal damage in MS. Because Th - 17 cells produce the cytokine IL - 17, researchers likewise thought this chemical was essential to the disease.

Plus, hopes for therapeutic cloning rest on the ability to produce embryonic stem cells from cells harvested from diseased patients.

The new research shows that when the atheronals interact with various blood cells, they produce some of the effects known to lead to heart disease, such as causing a malfunction in the cells that line arterial walls.

Although that marker, called IL21, had not previously been associated with autoimmune diseases, the gene that produces it sits right in the stretch of DNA known to make these mice vulnerable to diabetes, suggesting that IL21 might make a drug target, says Sarvetnick.Furthermore, by giving the animals a shot of dead bacteria — similar to an immunization in humans — when they were newborns, Sarvetnick and her colleagues prevented a surfeit of CD4 + and CD8 + cells.

«They continue to have the gene and they produce VEGF - A, but it's like the patient's cells don't realize they could be more protected or suffer from the disease much less if the cells produce more of this particular protective factor.»

In many cases, this procedure has produced long - lived dopamine - producing cells and reversed symptoms of the disease, such as rigidity, slowness, and tremor.

Parkinson's disease, which afflicts one million people in the United States, kills a class of brain cells that produce dopamine, one of the brain's chemical messengers.

«With a better understanding of how potential is regulated, it could be possible to broaden the development spectrum of aging stem cells, allowing them to regain their capacity to produce cell types from earlier development stages, which in the long - term perspective could be relevant to future treatment methods for neurodegenerative disease.»

Among these: There can be no changes to his protocol; the cells need to be produced at one facility, under the supervision of a Stamina biologist; and the trial must include patients with three different diseases.

Under pressure to name several possible future perspectives, Bente Vilsen mentions that the discovery of the electroneutral sodium - potassium pump also makes it possible to explore what an inability to produce current means for the development of the cells and the occurrence of diseases in e.g. the brain and kidneys, where the sodium - potassium pump plays a crucial role.

After initial infection, HSV enters a latent state in sensory nerve cells, periodically reactivating to produce disease.

Researchers from the University's Institute of Ageing and Chronic Disease, led by Senior Lecturer in Orthopaedic Sciences Dr Simon Tew, examined molecular messages produced by cartilage cells in both humans and rats.

In sickle cell disease, individuals have two copies of a genetic mutation that produces an abnormal change in hemoglobin, the primary molecule that carries oxygen in the blood.

The disease is caused by a genetic mutation that prevents a protein required to keep muscle cells intact from being produced.

However, when mature blood cells are lost, for example through severe bleeding or during infections, HSCs become activated to generate new «progenitor» cells — the cells that replenish the blood supply and produce immune cells to fight disease.

At the same point in the disease process, the scientists found no evidence of impairment in liver cells, which also produce the mutated huntingtin protein.

In previous studies, the same group along with others had demonstrated that microRNAs (miRNAs) produced by eukaryotic cells and viruses are present in human blood in highly stable, cell - free forms and these so called circulating miRNAs can serve as non-invasive biomarkers for the early diagnosis of various diseases, including viral diseases.

In the tea drinkers» immune systems, gamma delta T cells produced five times more infection - fighting interferon when exposed to disease - causing bacteria than did the T cells of the coffee drinkers.

The disease begins when a person's own antibodies attack the insulin - producing cells in the pancreas.

In principle, we hope to engineer T cells or other cell types to reside in the body long - term and produce therapeutics if they recognize disease or recurrence of disease.

Parkinson's disease occurs precisely because the group of nerve cells in the brain that produce dopamine stop working.

But scientists — who want to harness the potential of cells as living computers that can respond to disease, efficiently produce biofuels or develop plant - based chemicals — don't want to wait for evolution to craft their desired cellular system.

Patients with Parkinson's disease, cardiovascular disease, and cystic fibrosis may have something in common: cells in their disease - affected tissues may produce misfolded proteins that are incapable of functioning normally.

These damaged molecules trigger cell death that produces some human diseases, according to the researchers.

THE DEMENTIA associated with Alzheimer's disease may be caused by toxins that the body's own immune cells produce.

«Bacteria can only cause disease when virulence factors are appropriately produced by the bacteria and transported (or secreted) onto the cell surface where they become harmful,» says first author Matthew Doyle, PhD candidate in the School of Biological Sciences.

Through studies conducted in mice, Oliver M. Steinmetz, MD (University Hospital Hamburg Eppendorf, in Germany) and his colleagues have shown that the messenger protein IL - 6, which is rapidly produced at high levels during an acute inflammatory form of kidney disease, potently dampens activation of tissue - destructive immune cells called macrophages.