Sentences with phrase «cell disease programs»

Dr. Buchanan has led the institutional pediatric and research sickle cell disease programs for 37 years.

Not exact matches

BlueRock's first two programs are treatments that could regenerate heart muscle cells after heart attacks and help replace certain neurons in the brain as they decline in people with Parkinson's disease.

Realistic stem cell therapies to replace diseased or damaged tissue may still be years away, but researchers have uncovered a promising new use for these undifferentiated cells: they can be programmed to become patient - specific laboratory models of inherited liver disease.

Someday, researchers could «plug and play» programmed DNA into a variety of cells to address a variety of diseases, said study author Wilfred Chen, Gore Professor of Chemical Engineering.

«This is such a prevalent virus... about 25 percent of stem cell transplant patients get infected [with rhinovirus] during the first year,» said Boeckh, who heads Fred Hutch's Infectious Disease Sciences Program.

«Activation of these cell receptors appear to prevent brain cells from cleaning out the trash — the toxic buildup of proteins, such as alpha - synuclein, tau and amyloid, common in neurodegenerative diseases,» says the study's senior author, neurologist Charbel Moussa, MBBS, PhD, director of Georgetown's Laboratory for Dementia and Parkinsonism, and scientific and clinical research director of the GUMC Translational Neurotherapeutics Program.

To assess risk, Thomas Adamkiewicz, codirector of the Hemoglobinopathy / Genomics Training Program at Morehouse School of Medicine in Atlanta, surveyed four medical centers and found that seven children with sickle - cell disease had been treated with umbilical cord blood from unrelated donors.

«In my lab we've seen a direct interaction between fat cells and leukemia cells that may help explain this increased risk of disease relapse,» said Steven Mittelman, MD, PhD, director of the Diabetes and Obesity program at CHLA and senior author on the study.

As genetic circuitry shapes up, scientists hope the new device will make it easier for them to program cells to do things such as watch for disease, monitor pollution, or even turn on medicine output.

For example, how genetic programs affect the function of specific cell types, how they vary early or later in life and how dysfunction in these programs might contribute to disease, all of which could help scientists learn more about the fundamental workings of the brain.

But there's a great deal of overlap: For example, CRISPR Therapeutics and Editas have both made sickle cell disease and Duchenne muscular dystrophy a priority, and Intellia and Editas both have programs targeting the liver disease α - 1 antitrypsin deficiency and collaborations that focus on engineering T cells to fight cancer.

Prompted by health officials with a dim sense of genetics, the testing of African Americans for sickle - cell disease was a social program that, like the Tuskegee study, backfired on the group it was meant to benefit.

Students in the UBC program engage in a wide range of research: molecular mechanisms underlying cell proliferation in cancer or cell death in stroke; relating gene mutations to disease mechanisms; the social factors that determine access to health care for women living on the street.

8Taube / Koret Center for Neurodegenerative Disease Research and Roddenberry Stem Cell Program, San Francisco, California, USA.

PHILADELPHIA --(July 11, 2017)-- Researchers at The Wistar Institute, an international leader in biomedical research in the fields of cancer, immunology and infectious diseases, with collaborators at Indiana University Melvin and Bren Simon Cancer Center and Syndax Pharmaceuticals, Inc., (Nasdaq: SNDX) announce the results of a preclinical study demonstrating that entinostat, Syndax's oral, Class - I histone deacetylase inhibitor, enhances the antitumor effect of PD - 1 (programmed death receptor - 1) blockade through the inhibition of myeloid derived suppressor cells (MDSCs).

Kenneth Ataga, MD, director of the UNC Comprehensive Sickle Cell Program, was featured in a video by the American Society of Hematology in which he discussed the favorable results of a yearlong clinical trial studying crizanlizumab as a therapy to prevent and treat painful crisis events in patients with sickle cell diseCell Program, was featured in a video by the American Society of Hematology in which he discussed the favorable results of a yearlong clinical trial studying crizanlizumab as a therapy to prevent and treat painful crisis events in patients with sickle cell disecell disease.

Colleen Dansereau, RN, MSN, CPN Program Manager, Gene Therapy Program As manager of the Gene Therapy Program, Colleen administratively manages the CAR T - cell therapy program as well as all administrative responsibility for all of the gene therapy clinical trials that take place at Dana - Farber / Boston Children's, for conditions including sickle cell disease, Wiskott - Aldrich Syndrome (WAS), and chronic granulomatous diseaseProgram Manager, Gene Therapy Program As manager of the Gene Therapy Program, Colleen administratively manages the CAR T - cell therapy program as well as all administrative responsibility for all of the gene therapy clinical trials that take place at Dana - Farber / Boston Children's, for conditions including sickle cell disease, Wiskott - Aldrich Syndrome (WAS), and chronic granulomatous diseaseProgram As manager of the Gene Therapy Program, Colleen administratively manages the CAR T - cell therapy program as well as all administrative responsibility for all of the gene therapy clinical trials that take place at Dana - Farber / Boston Children's, for conditions including sickle cell disease, Wiskott - Aldrich Syndrome (WAS), and chronic granulomatous diseaseProgram, Colleen administratively manages the CAR T - cell therapy program as well as all administrative responsibility for all of the gene therapy clinical trials that take place at Dana - Farber / Boston Children's, for conditions including sickle cell disease, Wiskott - Aldrich Syndrome (WAS), and chronic granulomatous diseaseprogram as well as all administrative responsibility for all of the gene therapy clinical trials that take place at Dana - Farber / Boston Children's, for conditions including sickle cell disease, Wiskott - Aldrich Syndrome (WAS), and chronic granulomatous disease (CGD).

The donation will support an innovative program with three leading medical research groups and, for the first time, will introduce gene editing and stem cell therapies to effect treatments and, eventually, a potential cure for Huntington's disease.

«The support provided by this grant will allow UCSD to enhance our collaborative stem cell program so that we may accelerate our goals of improving health and conquering disease through regenerative medicine,» said Marye Anne Fox, UCSD Chancellor.

Dr. Haywood also serves as a member of the oversight steering committee for the Health Resources and Services Administration's Sickle Cell Disease Treatment Demonstration Program.

Writing in her local newspaper, the Davis Enterprise, Jan Nolta, the director of the Stem Cell Program at the UC Davis School of Medicine, highlighted the program's «numerous novel clinical trials ongoing and in the pipeline» and its 16 disease teams testing stem cells to treat the folloProgram at the UC Davis School of Medicine, highlighted the program's «numerous novel clinical trials ongoing and in the pipeline» and its 16 disease teams testing stem cells to treat the folloprogram's «numerous novel clinical trials ongoing and in the pipeline» and its 16 disease teams testing stem cells to treat the following...

«Every new technology is an opportunity for studying cells and tissues in greater detail,» said Broad core institute member Aviv Regev, a co-corresponding author on the paper, director of the Klarman Cell Observatory (KCO) at the Broad and the institute's Cell Circuits Program, and — along with Broad institute member and Infectious Disease and Microbiome Program co-director Ramnik Xavier — a co-corresponding author on the paper.

I - Stem continue to develop R & D programs of disease modeling and cell therapy as part of its third strategic plan whose main objective is to go achieve therapeutic hopes.

This makes a strong case for the utility of lineage through program cells for diseased modeling.

$ 1.8 M Supports Cancer Drug Discovery on Commonly Mutated Gene New Brunswick Patch — April 5, 2016 Behavioral Scientist Shares Insights about FDA's Proposed Rule on Banning Tanning Bed Use among Minors News-Medical.net - March 19, 2016 Intervention Program Reduces Caregiver Distress during Hospitalization of Pediatric Stem Cell Transplant Patients News-Medical.net - March 9, 2016 Exploring Genomic Pathways in the Development of Ovarian Cancer GMNews.com - March 2, 2016 Differences in Type of Small Protein may further Elucidate Lung Cancer Risk in African Americans ScienceDaily.com - March 2, 2016 Study Looks at Post-Treatment Resources for Prostate Cancer Patients Transitioning to Survivorship News-Medical.net - February 11, 2016 Drawing the Line on Tanning Bed Use by Teens ScienceDaily.com - December 21, 2015 What Rutgers Study Uncovered about E-Cigarette Use NJBiz.com - December 9, 2015 Identification of Barrier that Prevents Progression of Benign Kidney Tumors to Malignant Disease MedicalNewsToday.com - November, 24, 2015 What is the Color of the Lung Cancer Ribbon?

The Bone Marrow and Stem Cell Transplant Program is expanding the use of this technique for patients with solid tumors including neuroblastoma and brain tumors; a variety of high - risk hematologic diseases, such as thalassemia major and transfusion - dependent sickle cell disease; and other nonmalignant diseaCell Transplant Program is expanding the use of this technique for patients with solid tumors including neuroblastoma and brain tumors; a variety of high - risk hematologic diseases, such as thalassemia major and transfusion - dependent sickle cell disease; and other nonmalignant diseacell disease; and other nonmalignant diseases.

Please also take a look at the program of the workshop co-organised by NeuroStemcell / Transeuro Consortia: Imaging cell therapies in Parkinson's disease

Dr. Clive Svendsen of Cedars - Sinai will discuss a precision medicine program that uses patient cells to gain insights about intestinal diseases that have a strong genetic component.

Included among the numerous recipients of Mr. Sanford's gifts, that total more than one billion dollars, are: the Edith Sanford Foundation for Breast Cancer that was created in 2012 by a gift of $ 100 million in honor of Mr. Sanford's mother who died of breast cancer when he was four years old; the Sioux Valley Hospitals and Health System, which renamed itself Sanford Health in 2007, in recognition of a $ 400 million gift; a $ 125 million gift in 2014 to establish Sanford Imagenetics, a program that will integrate genomic medicine into primary care for adults; the University of California San Diego which received a $ 100 million gift for the creation of the Sanford Stem Cell Clinical Center in 2013 to accelerate the translation of stem cell research discoveries by advancing clinical trials and patient therapies; the Burnham Institute for Medical Research that received a $ 50 million gift in 2010, and recognized its appreciation for both this and a 2008 gift of $ 20 million to the Sanford Center for Childhood Disease research at Burnham by then changing its name to Sanford Burnham Medical Research Institute; a $ 70 million gift to establish a particle physics laboratory named the Sanford Underground Research Facility; and the San Diego Consortium for Regenerative Medicine which received a gift of $ 30 million in 2008 and expressed its gratitude by renaming itself the Sanford Consortium for Regenerative MedicCell Clinical Center in 2013 to accelerate the translation of stem cell research discoveries by advancing clinical trials and patient therapies; the Burnham Institute for Medical Research that received a $ 50 million gift in 2010, and recognized its appreciation for both this and a 2008 gift of $ 20 million to the Sanford Center for Childhood Disease research at Burnham by then changing its name to Sanford Burnham Medical Research Institute; a $ 70 million gift to establish a particle physics laboratory named the Sanford Underground Research Facility; and the San Diego Consortium for Regenerative Medicine which received a gift of $ 30 million in 2008 and expressed its gratitude by renaming itself the Sanford Consortium for Regenerative Mediccell research discoveries by advancing clinical trials and patient therapies; the Burnham Institute for Medical Research that received a $ 50 million gift in 2010, and recognized its appreciation for both this and a 2008 gift of $ 20 million to the Sanford Center for Childhood Disease research at Burnham by then changing its name to Sanford Burnham Medical Research Institute; a $ 70 million gift to establish a particle physics laboratory named the Sanford Underground Research Facility; and the San Diego Consortium for Regenerative Medicine which received a gift of $ 30 million in 2008 and expressed its gratitude by renaming itself the Sanford Consortium for Regenerative Medicine.

Through the activities of the Cell Circuits Program and the Klarman Cell Observatory, Broad researchers are working to systematically define the genetic and molecular circuits in a wide range of cell types, tissues, and diseaCell Circuits Program and the Klarman Cell Observatory, Broad researchers are working to systematically define the genetic and molecular circuits in a wide range of cell types, tissues, and diseaCell Observatory, Broad researchers are working to systematically define the genetic and molecular circuits in a wide range of cell types, tissues, and diseacell types, tissues, and diseases.

Funding was provided by the National Institutes of Neurological Disorders and Stroke (1K08NS072233 - 01A1, 3R01 NS039074, 2R01 NS045091, NS083390), the Robert Packard Center for ALS Research, Target ALS, the Roddenberry Stem Cell Program, the Koret / Taube Center for Neurodegenerative Disease, and the Protein Folding Diseases Initiative at the University of Michigan.

We are interested in genetic programs of neural stem cells (NSC) in brain development and postnatal neurogenesis, and in how NSC misregulation can lead to pathology (hereditary disease, cancer stem cells).

Discovered in the late 1970s, the mechanism, called the unfolded protein response, relies on communication between the ER and the cell nucleus: When misfolded proteins, which can cause stress - related diseases, accumulate in the ER, cells counter the surge by triggering a program of gene expression in the nucleus that raises the abundance of ER proteins that foster protein folding and activates a mechanism that degrades protein clumps.

Other programs will use cellular models of heart disease created from stem cells to identify potential new drug targets.

Children receiving care at Texas Children's Sickle Cell Program have the opportunity to participate in several National Institutes of Health (NIH)- funded research studies led by physician scientists, providing the latest treatments for this disease.

A major challenge that will be addressed in the second phase of LINCS is to optimize the combinations of cell types, perturbations and measurements of cellular responses to address a wider range of basic biological and disease - related problems than was possible in the program's initial pilot stage, said Alan Michelson, M.D., Ph.D., senior investigator, Laboratory of Developmental Systems Biology, NHLBI, and co-chair of the NIH LINCS Project Implementation Team.

The study supports the idea that patients with coronary artery disease may benefit from cardiac rehab programs, which drive the progenitor cells into the ischemic tissue, so they can contribute into vascular repair and regeneration.

The Sickle Cell Program conducts state - of - the - art clinical and laboratory research aimed at gaining a better understanding of the disease, preventing its complications and ultimately finding a cure.

In this program, an array of patient - derived isolates will be studied in mice, and parallel evaluation of immune cell dynamics and cytokine profiles will inform about potential correlates of disease or protection.

Programmed cell death is essential in organ development and tissue homeostasis and its deregulation is associated with the development of several diseases in mice and humans.

Because programmed cell death goes awry in leukemias and other cancers, Hu is currently examining lincRNA - EPS's function in normal and diseased human cells in an effort to determine whether it plays a role in tumor development and growth.

«As Program Director of Virology, he and his coworkers were at the forefront of new and fascinating studies using the electron microscope to detect and characterize viruses and phytoplasmas in cells of diseased plants and insect vectors.»

A tomato 14 -3-3 protein (TFT7) positively regulates immunity - associated programmed cell death mediated by diverse disease resistance proteins

This program has provided the first comprehensive picture of how a gene normally associated with cancer can influence development, survival and normal function of brain cells central to age - associated neurodegenerative disorders such as Parkinson's disease.

It is confirming that food provides potent dietary signals that directly influence the metabolic programming of our cells and modify the risk of common chronic diseases.

But the one that I am most proud of is the development (clinical trial) of the first and only remote telephonic mindfulness - based stress reduction program for individuals with Sickle Cell Disease and chronic pain.

This disease - fighting nutrient can slow the growth and development of new blood vessels that nourish tumors, increase a type of programmed cancer cell death known as apoptosis and reduce the proliferation of new cancer cells.

Liver disease has been of central importance with aging and programmed cell death pathways.

He tells of a program that allows users to manipulate models of cells and molecules, possibly searching for cures to terrible diseases.

Colorado State University had a pilot program using feline fat (adipose - derived MSCs) as a source of stem cells (mesenchymal stem cells = adipose - derived MSCs) in hopes that introducing them into cats with renal (kidney) disease would halt or slow the disease.